Dingwei Lei
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View article: Discovery of RNA‐Targeting Small Molecules: Challenges and Future Directions
Discovery of RNA‐Targeting Small Molecules: Challenges and Future Directions Open
RNA‐targeting small molecules represent a transformative frontier in drug discovery, offering novel therapeutic avenues for diseases traditionally deemed undruggable. This review explores the latest advancements in the development of RNA‐b…
View article: Association Between Dietary Vitamin Intake and Severe Abdominal Aortic Calcification in U.S. Adults: A SHAP-Based Machine Learning Analysis of NHANES 2013–2014
Association Between Dietary Vitamin Intake and Severe Abdominal Aortic Calcification in U.S. Adults: A SHAP-Based Machine Learning Analysis of NHANES 2013–2014 Open
Background: Severe abdominal aortic calcification (SAAC) significantly impacts families and society. Although vitamin intake is closely linked to SAAC, large-scale model-based dietary studies are scarce. This study compares machine learnin…
View article: Discovery of Small-Molecule Inhibitors Against Norovirus 3CLpro Using Structure-Based Virtual Screening and FlipGFP Assay
Discovery of Small-Molecule Inhibitors Against Norovirus 3CLpro Using Structure-Based Virtual Screening and FlipGFP Assay Open
Norovirus, a major cause of acute gastroenteritis, possesses a single-stranded positive-sense RNA genome. The viral 3C-like cysteine protease (3CLpro) plays a critical role in processing the viral polyprotein into mature non-structural pro…
View article: Correlations of visfatin with severity of acute myocardial infarction, cardiovascular risk factors and atrial fibrillation after percutaneous coronary intervention
Correlations of visfatin with severity of acute myocardial infarction, cardiovascular risk factors and atrial fibrillation after percutaneous coronary intervention Open
Background: To investigate the relationship between visfatin level in the peripheral blood of patients with acute myocardial infarction (AMI) patients and the severity of AMI, cardiovascular risk factors and atrial fibrillation after percu…