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View article: Ginsenoside Rg1 alleviates chronic testicular damage caused by cranial irradiation through the SCF/PI3K/Akt/mTOR pathway in mice
Ginsenoside Rg1 alleviates chronic testicular damage caused by cranial irradiation through the SCF/PI3K/Akt/mTOR pathway in mice Open
Objective: To investigate whether Ginsenoside Rg1 can mitigate the adverse effects of cranial irradiation on distal reproductive function in mice and to explore the underlying mechanisms. Methods: Forty male C57BL/6J mice were randomly div…
View article: SIRT1-Dependent Neuroprotection by Resveratrol in TOCP-Induced Spinal Cord Injury: Modulation of ER Stress and Autophagic Flux
SIRT1-Dependent Neuroprotection by Resveratrol in TOCP-Induced Spinal Cord Injury: Modulation of ER Stress and Autophagic Flux Open
This study explores the neuroprotective effects of resveratrol (Resv) against tri-o-cresyl phosphate (TOCP)-induced neurotoxicity in the spinal cord of adult hens. It is well documented that TOCP exposure causes significant neurodegenerati…
View article: Radioactivity concentration of 14C in the air of 14C urea breath test rooms and the resulting internal dose to medical staff
Radioactivity concentration of 14C in the air of 14C urea breath test rooms and the resulting internal dose to medical staff Open
Objective: To monitor the radioactivity concentration of 14C in the air of rooms used to perform 14C urea breath tests, and evaluate the contamination status of 14C released during such tests, and assess the occupational health risk to med…
View article: The uses of zebrafish (Danio rerio) as an in vivo model for toxicological studies: A review based on bibliometrics
The uses of zebrafish (Danio rerio) as an in vivo model for toxicological studies: A review based on bibliometrics Open
An in vivo model is necessary for toxicology. This review analyzed the uses of zebrafish (Danio rerio) in toxicology based on bibliometrics. Totally 56,816 publications about zebrafish from 2002 to 2023 were found in Web of Science Core Co…
View article: Effects of low dose radiation on behavior rhythm of zebrafish (Danio rerio)
Effects of low dose radiation on behavior rhythm of zebrafish (Danio rerio) Open
Biological rhythm refers to the internal regulation of various life activities of an organism, which are determined by the specific time structure sequences of each individual. Behavior rhythm is the most intuitive embodiment of biological…
View article: Neuroprotective Effect of α-Lipoic Acid against Aβ25–35-Induced Damage in BV2 Cells
Neuroprotective Effect of α-Lipoic Acid against Aβ25–35-Induced Damage in BV2 Cells Open
The prevalence of Alzheimer’s disease (AD) is significantly increasing due to the aging world population, and the currently available drug treatments cannot cure or even slow its progression. α-lipoic acid (LA) is a biological factor widel…
View article: Effects of hand-transmitted vibration on fingertip terminal nerve: A meta-analysis
Effects of hand-transmitted vibration on fingertip terminal nerve: A meta-analysis Open
BackgroundHand-transmitted vibration is one of the most common occupational hazards and is closely related to symptoms of fingertip terminal nerve damage. ObjectiveTo analyze the effects of hand-transmitted vibration on the terminal nerve …
View article: Advances on nervous system impairment induced by hand-transmitted vibration
Advances on nervous system impairment induced by hand-transmitted vibration Open
Hand-transmitted vibration is one of the most common physical harmful factors in the workplace，and the hand-arm vibration syndrome caused by it lacks effective treatment, and seriously affects the physical and mental health of the involved…
View article: Direct analysis method of 14C radioactivity concentration in urine samples
Direct analysis method of 14C radioactivity concentration in urine samples Open
Objective: To establish a rapid analysis method for the activity concentration of carbon-14 (14C) in urine, in order to estimate the internal dose of 14C exposure, and to protect the health of occupational population. Methods: Liquid scint…
View article: Transient receptor potential ankyrin 1 and calcium: Interactions and association with disease (Review)
Transient receptor potential ankyrin 1 and calcium: Interactions and association with disease (Review) Open
Calcium (Ca2+) is an essential signaling molecule in all cells. It is involved in numerous fundamental functions, including cell life and death. Abnormal regulation of Ca2+ homeostasis may cause human diseases. Usually known as a member of…
View article: Circular RNA expression profiles in human bronchial epithelial cells treated with beryllium sulfate
Circular RNA expression profiles in human bronchial epithelial cells treated with beryllium sulfate Open
Circular RNAs (circRNAs), is a novel type of endogenous non-coding RNAs (ncRNAs) participated in the pathogenesis of many diseases. Beryllium is one of the carcinogenesis elements. However, the mechanism and function of circRNAs in human b…
View article: Characterization and Mechanism of Linearized-Microcystinase Involved in Bacterial Degradation of Microcystins
Characterization and Mechanism of Linearized-Microcystinase Involved in Bacterial Degradation of Microcystins Open
Microcystins (MCs) are extremely hazardous to the ecological environment and public health. How to control and remove MCs is an unsolved problem all over the world. Some microbes and their enzymes are thought to be effective in degrading M…
View article: Nrf2 and Ferroptosis: A New Research Direction for Neurodegenerative Diseases
Nrf2 and Ferroptosis: A New Research Direction for Neurodegenerative Diseases Open
Ferroptosis is a kind of regulated cell death (RCD) caused by the redox state disorder of intracellular microenvironment controlled by glutathione (GSH) peroxidase 4 (GPX4), which is inhibited by iron chelators and lipophilic antioxidants.…
View article: Time-Course Changes in Urine Metabolic Profiles of Rats Following 90-Day Exposure to Propoxur
Time-Course Changes in Urine Metabolic Profiles of Rats Following 90-Day Exposure to Propoxur Open
As a major kind of carbamate insecticide, propoxur plays an important role in agriculture, veterinary medicine, and public health. The acute toxicity of propoxur is mainly neurotoxicity due to the inhibition of cholinesterase. However, lit…
View article: Differential methylation values in differential methylation analysis
Differential methylation values in differential methylation analysis Open
Motivation Both β-value and M-value have been used as metrics to measure methylation levels. The M-value is more statistically valid for the differential analysis of methylation levels. However, the β-value is much more biologically interp…
View article: Differential expression of NPM, GSTA3, and GNMT in mouse liver following long-term <i>in vivo</i> irradiation by means of uranium tailings
Differential expression of NPM, GSTA3, and GNMT in mouse liver following long-term <i>in vivo</i> irradiation by means of uranium tailings Open
Uranium tailings (UT) are formed as a byproduct of uranium mining and are of potential risk to living organisms. In the present study, we sought to identify potential biomarkers associated with chronic exposure to low dose rate γ radiation…
View article: Brain-Derived Neurotrophic Factor Mediated Perfluorooctane Sulfonate Induced-Neurotoxicity via Epigenetics Regulation in SK-N-SH Cells
Brain-Derived Neurotrophic Factor Mediated Perfluorooctane Sulfonate Induced-Neurotoxicity via Epigenetics Regulation in SK-N-SH Cells Open
Perfluorooctane sulfonate (PFOS), a new kind of persistent organic pollutant, is widely distributed in the environment and exists in various organisms, where it is also a neurotoxic compound. However, the potential mechanism of its neuroto…
View article: Silver nanoparticles induced oxidative and endoplasmic reticulum stresses in mouse tissues: implications for the development of acute toxicity after intravenous administration
Silver nanoparticles induced oxidative and endoplasmic reticulum stresses in mouse tissues: implications for the development of acute toxicity after intravenous administration Open
AgNPs cause toxic damage by gradually imposing stress impacts on the target organs in mice.