Dino Vaira
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View article: Updating Primary Antibiotic Resistance in Helicobacter pylori Strains Isolated in Italy
Updating Primary Antibiotic Resistance in Helicobacter pylori Strains Isolated in Italy Open
Background and Aims: Bacterial resistance toward the most used antibiotics is increasing in Helicobacter pylori (H. pylori) strains worldwide. The emergence of multidrug resistance significantly affects the efficacy of standard therapy reg…
View article: Role of compliance in <i>Helicobacter pylori</i> eradication treatment: Results of the European Registry on <i>H. pylori</i> management
Role of compliance in <i>Helicobacter pylori</i> eradication treatment: Results of the European Registry on <i>H. pylori</i> management Open
Background Adherence to Helicobacter pylori (H. pylori) eradication treatment is a cornerstone for achieving adequate treatment efficacy. Objective To determine which factors influence compliance with treatment. Methods A systematic prospe…
View article: Role of proton pump inhibitors dosage and duration in <i>Helicobacter pylori</i> eradication treatment: Results from the European Registry on <i>H. pylori</i> management
Role of proton pump inhibitors dosage and duration in <i>Helicobacter pylori</i> eradication treatment: Results from the European Registry on <i>H. pylori</i> management Open
Background Management of Helicobacter pylori ( H. pylori ) infection requires co‐treatment with proton pump inhibitors (PPIs) and the use of antibiotics to achieve successful eradication. Aim To evaluate the role of dosage of PPIs and the …
View article: Author Correction: Comparison of the management of Helicobacter pylori infection between the older and younger European populations
Author Correction: Comparison of the management of Helicobacter pylori infection between the older and younger European populations Open
View article: Comparison of the management of Helicobacter pylori infection between the older and younger European populations
Comparison of the management of Helicobacter pylori infection between the older and younger European populations Open
View article: Analysis of Clinical Phenotypes through Machine Learning of First-Line H. pylori Treatment in Europe during the Period 2013–2022: Data from the European Registry on H. pylori Management (Hp-EuReg)
Analysis of Clinical Phenotypes through Machine Learning of First-Line H. pylori Treatment in Europe during the Period 2013–2022: Data from the European Registry on H. pylori Management (Hp-EuReg) Open
The segmentation of patients into homogeneous groups could help to improve eradication therapy effectiveness. Our aim was to determine the most important treatment strategies used in Europe, to evaluate first-line treatment effectiveness a…
View article: Helicobacter pylori Diagnostic Tests Used in Europe: Results of over 34,000 Patients from the European Registry on Helicobacter pylori Management
Helicobacter pylori Diagnostic Tests Used in Europe: Results of over 34,000 Patients from the European Registry on Helicobacter pylori Management Open
Background and aims: Several methods are available to diagnose Helicobacter pylori infection. Our objective was to evaluate the tests used for both the initial diagnosis and the confirmation of eradication after treatment in Europe. Method…
View article: Helicobacter pylori eradication and aspirin: a puzzle yet to be solved
Helicobacter pylori eradication and aspirin: a puzzle yet to be solved Open
View article: Department of Error
Department of Error Open
View article: Department of Error
Department of Error Open
View article: Effectiveness of first and second‐line empirical treatment in Italy: Results of the European registry on <i>Helicobacter pylori</i> management
Effectiveness of first and second‐line empirical treatment in Italy: Results of the European registry on <i>Helicobacter pylori</i> management Open
Background and Aims The optimal management of naïve and not naïve Helicobacter pylori patients remains unclear. Therefore, it is essential to evaluate whether the actual clinical practice mirrors the indications suggested by the guidelines…
View article: Experience with Rifabutin-Containing Therapy in 500 Patients from the European Registry on Helicobacter pylori Management (Hp-EuReg)
Experience with Rifabutin-Containing Therapy in 500 Patients from the European Registry on Helicobacter pylori Management (Hp-EuReg) Open
Background: First-line Helicobacter pylori (H. pylori) treatments have been relatively well evaluated; however, it remains necessary to identify the most effective rescue treatments. Our aim was to assess the effectiveness and safety of H.…
View article: Empirical Second-Line Therapy in 5000 Patients of the European Registry on Helicobacter pylori Management (Hp-EuReg)
Empirical Second-Line Therapy in 5000 Patients of the European Registry on Helicobacter pylori Management (Hp-EuReg) Open
View article: Antibiotic Resistance Prevalence and Trends in Patients Infected with Helicobacter pylori in the Period 2013–2020: Results of the European Registry on H. pylori Management (Hp-EuReg)
Antibiotic Resistance Prevalence and Trends in Patients Infected with Helicobacter pylori in the Period 2013–2020: Results of the European Registry on H. pylori Management (Hp-EuReg) Open
Background: Bacterial antibiotic resistance changes over time depending on multiple factors; therefore, it is essential to monitor the susceptibility trends to reduce the resistance impact on the effectiveness of various treatments. Object…
View article: The Role of Statins on Helicobacter pylori Eradication: Results from the European Registry on the Management of H. pylori (Hp-EuReg)
The Role of Statins on Helicobacter pylori Eradication: Results from the European Registry on the Management of H. pylori (Hp-EuReg) Open
Statins could increase the effectiveness of Helicobacter pylori eradication therapies due to their anti-inflammatory effect. The aim of this study was to analyze the impact of this therapeutic association in real life. This is a multicente…
View article: Rescue Therapies for H. pylori Infection in Italy
Rescue Therapies for H. pylori Infection in Italy Open
Background/Aims: Curing Helicobacter pylori infection remains challenging for clinicians, as no proposed first-line therapy achieves bacterial eradication in all treated patients so that several patients need two or more consecutive treatm…
View article: Next Generation Sequencing for the Prediction of the Antibiotic Resistance in Helicobacter pylori: A Literature Review
Next Generation Sequencing for the Prediction of the Antibiotic Resistance in Helicobacter pylori: A Literature Review Open
Background and aims: Only a few antimicrobials are effective against H. pylori, and antibiotic resistance is an increasing problem for eradication therapies. In 2017, the World Health Organization categorized clarithromycin resistant H. py…
View article: European Registry on <i>Helicobacter pylori</i> management: Single‐capsule bismuth quadruple therapy is effective in real‐world clinical practice
European Registry on <i>Helicobacter pylori</i> management: Single‐capsule bismuth quadruple therapy is effective in real‐world clinical practice Open
Background There has been resurgence in the use of bismuth quadruple therapy (proton pump inhibitor, bismuth, tetracycline and metronidazole) for treating Helicobacter pylori infection thanks to a three‐in‐one single‐capsule formulation. O…
View article: European Registry on<i>Helicobacter pylori</i>management (Hp-EuReg): patterns and trends in first-line empirical eradication prescription and outcomes of 5 years and 21 533 patients
European Registry on<i>Helicobacter pylori</i>management (Hp-EuReg): patterns and trends in first-line empirical eradication prescription and outcomes of 5 years and 21 533 patients Open
Objective The best approach for Helicobacter pylori management remains unclear. An audit process is essential to ensure clinical practice is aligned with best standards of care. Design International multicentre prospective non-intervention…
View article: Trends in Primary Antibiotic Resistance in H. pylori Strains Isolated in Italy between 2009 and 2019
Trends in Primary Antibiotic Resistance in H. pylori Strains Isolated in Italy between 2009 and 2019 Open
Background and aims: the increasing prevalence of strains resistant to antimicrobial agents is a critical issue for the management of Helicobacter pylori infection. This study aimed to evaluate, in Italian naïve patients, H. pylori antibio…
View article: Efficacy of a New Nutraceutical Formulation in Patients with Symptomatic Uncomplicated Diverticular Disease (SUDD): a Prospective Observational Study
Efficacy of a New Nutraceutical Formulation in Patients with Symptomatic Uncomplicated Diverticular Disease (SUDD): a Prospective Observational Study Open
Background and Aim: Symptomatic uncomplicated diverticular disease (SUDD) is characterized by abdominal pain, bloating and altered bowel habits (constipation or diarrhea) attributed to diverticula in the absence of macroscopic mucosal alte…
View article: Upper Endoscopy in Patients with Extra-Oesophageal Reflux Symptoms: A Multicentre Study
Upper Endoscopy in Patients with Extra-Oesophageal Reflux Symptoms: A Multicentre Study Open
Background: There are no evidence-based recommendations for performing upper gastrointestinal endoscopy (UGIE) in patients with extra-oesophageal symptoms of gastro-oesophageal reflux disease (GORD). However, UGIEs are often …
View article: Clinical Performance of the Automated LIAISON® Meridian <i>H. pylori</i> SA Stool Antigen Test
Clinical Performance of the Automated LIAISON® Meridian <i>H. pylori</i> SA Stool Antigen Test Open
Background . Antigens derived from Helicobacter pylori can be used as stool biomarkers to assist in the diagnosis of H. pylori infection. Since current assays have variable performance, we assessed the clinical performance of the automated…
View article: Sequential Therapy for First-Line Helicobacter pylori Eradication: 10- or 14-Day Regimen?
Sequential Therapy for First-Line Helicobacter pylori Eradication: 10- or 14-Day Regimen? Open
Background & Aim: Standard 10-day sequential therapy is advised as first-line therapy for Helicobacter pylori (H. pylori) eradication by current Italian guidelines. Some data suggested that a 14-day regimen may achieve higher eradication r…
View article: Whipple’s Disease: Case Report and Review of the Literature
Whipple’s Disease: Case Report and Review of the Literature Open
Whipple’s disease (WD) is known as an infrequent, systemic, chronic infection caused by the actinomycete Tropherima whipplei (T. whipplei). The disease is frequently characterized by a long prodromal and protean extra-intestinal phase, whi…
View article: A Novel Stool PCR Test for Helicobacter pylori May Predict Clarithromycin Resistance and Eradication of Infection at a High Rate
A Novel Stool PCR Test for Helicobacter pylori May Predict Clarithromycin Resistance and Eradication of Infection at a High Rate Open
Clarithromycin-based regimens are commonly used as a first-line therapy for Helicobacter pylori -positive patients; however, resistance to clarithromycin has led to treatment failures. The aim of this study was to evaluate the feasibility …
View article: Two-week Triple Therapy with either Standard or High-dose Esomeprazole for First-line H. pylori Eradication
Two-week Triple Therapy with either Standard or High-dose Esomeprazole for First-line H. pylori Eradication Open
Background & Aims: The updated Italian guidelines advise a standard 14-day triple therapy for first-line H. pylori eradication. This prospective study evaluated the cure rate following a 14-day triple therapy with either a standard or doub…
View article: A Systematic Review on Drugs Absorption Modifications after Eradication in Helicobacter pylori Positive Patients undergoing Replacement Therapy
A Systematic Review on Drugs Absorption Modifications after Eradication in Helicobacter pylori Positive Patients undergoing Replacement Therapy Open
Background & Aims: Helicobacter pylori (H. pylori) infection has been suggested as a cause of impaired drug absorption. This infection leads to alteration of the gastric acid secretion that may change the conformational characteristics of …