Diogo Meyer
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View article: kir‐mapper: A Toolkit for Killer‐Cell Immunoglobulin‐Like Receptor (<scp>KIR</scp>) Genotyping From Short‐Read Second‐Generation Sequencing Data
kir‐mapper: A Toolkit for Killer‐Cell Immunoglobulin‐Like Receptor (<span>KIR</span>) Genotyping From Short‐Read Second‐Generation Sequencing Data Open
Killer cell immunoglobulin‐like receptors (KIRs) regulate natural killer (NK) cell responses by activating or inhibiting their functions. Genotyping KIR genes from short‐read second‐generation sequencing data remains challenging as cross‐a…
View article: Genetic ancestry and the colonial legacies of race in genomics: a cross-disciplinary dialogue
Genetic ancestry and the colonial legacies of race in genomics: a cross-disciplinary dialogue Open
As genomics initiatives have spread around the world–often in the name of genetic diversity and inclusion–they have not only invoked promises of a medical revolution, but also revived categories of human difference that resemble erstwhile …
View article: A multi‐ethnic reference panel to impute <i>HLA</i> classical and non‐classical class I alleles in admixed samples: Testing imputation accuracy in an admixed sample from Brazil
A multi‐ethnic reference panel to impute <i>HLA</i> classical and non‐classical class I alleles in admixed samples: Testing imputation accuracy in an admixed sample from Brazil Open
The MHC class I region contains crucial genes for the innate and adaptive immune response, playing a key role in susceptibility to many autoimmune and infectious diseases. Genome‐wide association studies have identified numerous disease‐as…
View article: 'n Koorspenlesing van onsekere tye: Informele dagarbeiders in Johannesburg se subjektiewe welstand tydens COVID-19
'n Koorspenlesing van onsekere tye: Informele dagarbeiders in Johannesburg se subjektiewe welstand tydens COVID-19 Open
In Suid-Afrika het deurlopende uitdagings met werkloosheid daartoe gelei dat baie individue geleenthede in die informele sektor soek in 'n poging om 'n bestaan te maak. Die aanvang van die COVID-19-pandemie het regeringsinperkingsmaatreëls…
View article: 18th International <scp>HLA</scp> and Immunogenetics Workshop: Report on the <scp>SNP‐HLA</scp> Reference Consortium (<scp>SHLARC</scp>) component
18th International <span>HLA</span> and Immunogenetics Workshop: Report on the <span>SNP‐HLA</span> Reference Consortium (<span>SHLARC</span>) component Open
The SNP‐HLA Reference Consortium (SHLARC), a component of the 18th International HLA and Immunogenetics Workshop, is aimed at collecting diverse and extensive human leukocyte antigen (HLA) data to create custom reference panels and enhance…
View article: Inferring Balancing Selection From Genome-Scale Data
Inferring Balancing Selection From Genome-Scale Data Open
The identification of genomic regions and genes that have evolved under natural selection is a fundamental objective in the field of evolutionary genetics. While various approaches have been established for the detection of targets of posi…
View article: Comparison between qPCR and RNA-seq reveals challenges of quantifying HLA expression
Comparison between qPCR and RNA-seq reveals challenges of quantifying HLA expression Open
View article: MUC22, HLA-A, and HLA-DOB variants and COVID-19 in resilient super-agers from Brazil
MUC22, HLA-A, and HLA-DOB variants and COVID-19 in resilient super-agers from Brazil Open
Background Although aging correlates with a worse prognosis for Covid-19, super elderly still unvaccinated individuals presenting mild or no symptoms have been reported worldwide. Most of the reported genetic variants responsible for incre…
View article: How HLA diversity is apportioned: influence of selection and relevance to transplantation
How HLA diversity is apportioned: influence of selection and relevance to transplantation Open
In his 1972 paper ‘The apportionment of human diversity’, Lewontin showed that, when averaged over loci, genetic diversity is predominantly attributable to differences among individuals within populations. However, selection can alter the …
View article: Author Correction: Whole-genome sequencing of 1,171 elderly admixed individuals from Brazil
Author Correction: Whole-genome sequencing of 1,171 elderly admixed individuals from Brazil Open
View article: Whole-genome sequencing of 1,171 elderly admixed individuals from Brazil
Whole-genome sequencing of 1,171 elderly admixed individuals from Brazil Open
View article: Population structure in the MHC region
Population structure in the MHC region Open
In his 1972 “The apportionment of human diversity”, Lewontin showed that, when averaged over loci, genetic diversity is predominantly attributable to differences among individuals within populations. However, selection on specific genes an…
View article: MHC Variants Associated With Symptomatic Versus Asymptomatic SARS-CoV-2 Infection in Highly Exposed Individuals
MHC Variants Associated With Symptomatic Versus Asymptomatic SARS-CoV-2 Infection in Highly Exposed Individuals Open
Despite the high number of individuals infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who develop coronavirus disease 2019 (COVID-19) symptoms worldwide, many exposed individuals remain asymptomatic and/or uninfec…
View article: Putative pathogen-selected polymorphisms in the PKLR gene are associated with mycobacterial susceptibility in Brazilian and African populations
Putative pathogen-selected polymorphisms in the PKLR gene are associated with mycobacterial susceptibility in Brazilian and African populations Open
Pyruvate kinase (PK), encoded by the PKLR gene, is a key player in glycolysis controlling the integrity of erythrocytes. Due to Plasmodium selection, mutations for PK deficiency, which leads to hemolytic anemia, are associated with resista…
View article: Genetic variation among major human geographic groups supports a peculiar evolutionary trend in PAX9
Genetic variation among major human geographic groups supports a peculiar evolutionary trend in PAX9 Open
A total of 172 persons from nine South Amerindian, three African and one Eskimo populations were studied in relation to the Paired box gene 9 (PAX9) exon 3 (138 base pairs) as well as its 59and 39flanking intronic segments (232 bp and 220 …
View article: Frequency and origin of the c.2090T>G p.(Leu697Trp) MYO3A variant associated with autosomal dominant hearing loss
Frequency and origin of the c.2090T>G p.(Leu697Trp) MYO3A variant associated with autosomal dominant hearing loss Open
View article: “Immunogenetics of resistance to SARS-CoV-2 infection in discordant couples”
“Immunogenetics of resistance to SARS-CoV-2 infection in discordant couples” Open
Background Despite the high number of individuals infected by SARS-CoV-2 who develop COVID-19 symptoms worldwide, many exposed individuals remain asymptomatic and/or stay uninfected. This could be explained by a combination of environmenta…
View article: How natural selection shapes genetic differentiation in the MHC region: A case study with Native Americans
How natural selection shapes genetic differentiation in the MHC region: A case study with Native Americans Open
View article: An immunogenetic view of COVID-19
An immunogenetic view of COVID-19 Open
Meeting the challenges brought by the COVID-19 pandemic requires an interdisciplinary approach. In this context, integrating knowledge of immune function with an understanding of how genetic variation influences the nature of immunity is a…
View article: An immunogenetic view of COVID-19
An immunogenetic view of COVID-19 Open
Meeting the challenges brought by the COVID-19 pandemic requires an interdisciplinary approach. In this context, integrating knowledge of immune function with an understanding of how genetic variation influences the nature of immunity is a…
View article: How Ancestry Influences the Chances of Finding Unrelated Donors: An Investigation in Admixed Brazilians
How Ancestry Influences the Chances of Finding Unrelated Donors: An Investigation in Admixed Brazilians Open
A match of HLA loci between patients and donors is critical for successful hematopoietic stem cell transplantation. However, the extreme polymorphism of HLA loci - an outcome of millions of years of natural selection - reduces the chances …
View article: Demographic history and selection at HLA loci in Native Americans
Demographic history and selection at HLA loci in Native Americans Open
The American continent was the last to be occupied by modern humans, and native populations bear the marks of recent expansions, bottlenecks, natural selection, and population substructure. Here we investigate how this demographic history …
View article: Whole-genome sequencing of 1,171 elderly admixed individuals from the largest Latin American metropolis (São Paulo, Brazil)
Whole-genome sequencing of 1,171 elderly admixed individuals from the largest Latin American metropolis (São Paulo, Brazil) Open
As whole-genome sequencing (WGS) becomes the gold standard tool for studying population genomics and medical applications, data on diverse non-European and admixed individuals are still scarce. Here, we present a high-coverage WGS dataset …
View article: Whole-genome sequencing of 1,171 elderly admixed individuals from the largest Latin American metropolis (São Paulo, Brazil)
Whole-genome sequencing of 1,171 elderly admixed individuals from the largest Latin American metropolis (São Paulo, Brazil) Open
As whole-genome sequencing (WGS) becomes the gold standard tool for studying population genomics and medical applications, data on diverse non-European and admixed individuals are still scarce. Here, we present a high-coverage WGS dataset …
View article: SNP‐HLA Reference Consortium (SHLARC): HLA and SNP data sharing for promoting MHC‐centric analyses in genomics
SNP‐HLA Reference Consortium (SHLARC): HLA and SNP data sharing for promoting MHC‐centric analyses in genomics Open
Genome‐wide associations studies have repeatedly identified the major histocompatibility complex genomic region (6p21.3) as key in immune pathologies. Researchers have also aimed to extend the biological interpretation of associations by f…
View article: <scp><i>HLA‐C</i></scp> genetic diversity and evolutionary insights in two samples from Brazil and Benin
<span><i>HLA‐C</i></span> genetic diversity and evolutionary insights in two samples from Brazil and Benin Open
Human leukocyte antigen‐C (HLA‐C) is a classical HLA class I molecule that binds and presents peptides to cytotoxic T lymphocytes in the cell surface. HLA‐C has a dual function because it also interacts with Killer‐cell immunoglobulin‐like…
View article: Pathogen-selected polymorphisms in the PKLR gene are associated with mycobacterial susceptibility in Brazilian and African populations
Pathogen-selected polymorphisms in the PKLR gene are associated with mycobacterial susceptibility in Brazilian and African populations Open
Data and metadata for the publication: "Pathogen-selected polymorphisms in the PKLR gene are associated with mycobacterial susceptibility in Brazilian and African populations" by …
View article: Pathogen-selected polymorphisms in the PKLR gene are associated with mycobacterial susceptibility in Brazilian and African populations
Pathogen-selected polymorphisms in the PKLR gene are associated with mycobacterial susceptibility in Brazilian and African populations Open
Data and metadata for the publication: "Pathogen-selected polymorphisms in the PKLR gene are associated with mycobacterial susceptibility in Brazilian and African populations" by …
View article: Pathogen-Selected Polymorphisms in the <i>PKLR</i> Gene Are Associated with Mycobacterial Susceptibility in Brazilian and African Populations
Pathogen-Selected Polymorphisms in the <i>PKLR</i> Gene Are Associated with Mycobacterial Susceptibility in Brazilian and African Populations Open
View article: Early Pleistocene divergence of<i>Pelagia noctiluca</i>populations (Cnidaria, Medusozoa) between the Atlantic Ocean and the Mediterranean Sea
Early Pleistocene divergence of<i>Pelagia noctiluca</i>populations (Cnidaria, Medusozoa) between the Atlantic Ocean and the Mediterranean Sea Open
A previous study detected mixing of two deeply split mtDNA clades (Clade I and Clade II) for Atlantic and Mediterranean populations of the medusozoan Pelagia noctiluca . The north hemisphere glaciations and the Messinian salinity crisis ha…