Dipak Kotecha
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View article: Machine learning-enabled systematic review on coded healthcare data in heart failure research
Machine learning-enabled systematic review on coded healthcare data in heart failure research Open
Aims Coded healthcare data are now commonly used in clinical research. This study aimed to assess the transparency of reporting within heart failure studies and employ machine learning to facilitate larger-scale evaluation. Methods & Resul…
View article: Low‐dose digoxin improves cardiac function in patients with heart failure, preserved ejection fraction and atrial fibrillation – the <scp>RATE</scp>‐<scp>AF</scp> randomized trial
Low‐dose digoxin improves cardiac function in patients with heart failure, preserved ejection fraction and atrial fibrillation – the <span>RATE</span>‐<span>AF</span> randomized trial Open
Aims To compare the effect of digoxin versus beta‐blockers on left ventricular function, in patients with permanent atrial fibrillation (AF) and symptoms of heart failure within the RATE‐AF randomized trial. Methods and results Blinded ech…
View article: CardAIc-Agents: A Multimodal Framework with Hierarchical Adaptation for Cardiac Care Support
CardAIc-Agents: A Multimodal Framework with Hierarchical Adaptation for Cardiac Care Support Open
Cardiovascular diseases (CVDs) remain the foremost cause of mortality worldwide, a burden worsened by a severe deficit of healthcare workers. Artificial intelligence (AI) agents have shown potential to alleviate this gap through automated …
View article: Atrial cardiomyopathy: From healthy atria to atrial failure. A clinical consensus statement of the Heart Failure Association of the <scp>ESC</scp>
Atrial cardiomyopathy: From healthy atria to atrial failure. A clinical consensus statement of the Heart Failure Association of the <span>ESC</span> Open
The importance of atrial cardiomyopathy (AtCM) as a specific clinical entity is increasingly recognized. Past definitions have varied, and the lack of consistent cut‐offs for imaging parameters and biomarkers have limited clinical utility …
View article: Combination of heart failure and atrial fibrillation worsens ethnicity-related disparity: An individual patient-level meta-analysis of randomised trials
Combination of heart failure and atrial fibrillation worsens ethnicity-related disparity: An individual patient-level meta-analysis of randomised trials Open
Aims Ethnicity is known to influence patient outcomes and treatment efficacy, but knowledge is limited how multimorbidity interacts with clinical events, for example when heart failure (HF) and atrial fibrillation (AF) combine. Methods and…
View article: Guideline-based education on stroke prevention and rhythm control in atrial fibrillation: A survey in the STEEER-AF study
Guideline-based education on stroke prevention and rhythm control in atrial fibrillation: A survey in the STEEER-AF study Open
Background The value of guideline-related education for healthcare professionals is unknown. The STEEER-AF trial (Stroke prevention and rhythm control Treatment: Evaluation of an Educational programme of the European Society of Cardiology …
View article: 2024 Revision of the level of evidence grading system for ESC clinical practice guideline recommendations I: therapy and prevention
2024 Revision of the level of evidence grading system for ESC clinical practice guideline recommendations I: therapy and prevention Open
The level of evidence (LOE) grading system for ESC Clinical Practice Guidelines classifies the quality of the evidence supporting a recommendation. However, the current taxonomy does not fully consider the optimal study design necessary to…
View article: Cost-effectiveness of digoxin versus beta blockers in permanent atrial fibrillation: the Rate Control Therapy Evaluation in Permanent Atrial Fibrillation (RATE-AF) randomised trial
Cost-effectiveness of digoxin versus beta blockers in permanent atrial fibrillation: the Rate Control Therapy Evaluation in Permanent Atrial Fibrillation (RATE-AF) randomised trial Open
Background Atrial fibrillation (AF) is a major and increasing burden on health services. This study aimed to evaluate the cost-effectiveness of digoxin versus beta-blockers for heart rate control in patients with permanent AF and symptoms …
View article: Spotlight on the 2024 ESC/EACTS management of atrial fibrillation guidelines: 10 novel key aspects
Spotlight on the 2024 ESC/EACTS management of atrial fibrillation guidelines: 10 novel key aspects Open
Atrial fibrillation (AF) remains the most common cardiac arrhythmia worldwide and is associated with significant morbidity and mortality. The European Society of Cardiology (ESC)/European Association for Cardio-Thoracic Surgery (EACTS) hav…
View article: The impact of ethnicity on clinical outcomes in patients with heart failure and atrial fibrillation
The impact of ethnicity on clinical outcomes in patients with heart failure and atrial fibrillation Open
Introduction Heart failure (HF) and atrial fibrillation (AF) are increasingly prevalent and associated with substantial morbidity (1,2). When HF and AF co-exist, the outcome profile is significantly worse than for either condition in isola…
View article: Gender and contemporary risk of adverse events in atrial fibrillation
Gender and contemporary risk of adverse events in atrial fibrillation Open
Background and Aims The role of gender in decision-making for oral anticoagulation in patients with atrial fibrillation (AF) remains controversial. Methods The population cohort study used electronic healthcare records of 16 587 749 patien…
View article: 2024 ESC Guidelines for the management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS)
2024 ESC Guidelines for the management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS) Open
Guidelines on the management of atrial fibrillation.
View article: Consumer wearable devices for evaluation of heart rate control using digoxin versus beta-blockers: the RATE-AF randomized trial
Consumer wearable devices for evaluation of heart rate control using digoxin versus beta-blockers: the RATE-AF randomized trial Open
Consumer-grade wearable technology has the potential to support clinical research and patient management. Here, we report results from the RATE-AF trial wearables study, which was designed to compare heart rate in older, multimorbid patien…
View article: Design and deployment of the STEEER-AF trial to evaluate and improve guideline adherence: a cluster-randomized trial by the European Society of Cardiology and European Heart Rhythm Association
Design and deployment of the STEEER-AF trial to evaluate and improve guideline adherence: a cluster-randomized trial by the European Society of Cardiology and European Heart Rhythm Association Open
Aims The aim is to describe the rationale, design, delivery, and baseline characteristics of the Stroke prevention and rhythm control Treatment: Evaluation of an Educational programme of the European society of cardiology in a cluster-Rand…
View article: 96 The impact of ethnicity on clinical outcomes in patients with heart failure and atrial fibrillation
96 The impact of ethnicity on clinical outcomes in patients with heart failure and atrial fibrillation Open
Introduction Heart failure (HF) and atrial fibrillation (AF) are increasingly prevalent and associated with substantial morbidity. When HF and AF co-exist, the outcome profile is significantly worse than for either condition in isolation. …
View article: Development of automated neural network prediction for echocardiographic left ventricular ejection fraction
Development of automated neural network prediction for echocardiographic left ventricular ejection fraction Open
Introduction The echocardiographic measurement of left ventricular ejection fraction (LVEF) is fundamental to the diagnosis and classification of patients with heart failure (HF). Methods This paper aimed to quantify LVEF automatically and…
View article: Longer and better lives for patients with atrial fibrillation: the 9th AFNET/EHRA consensus conference
Longer and better lives for patients with atrial fibrillation: the 9th AFNET/EHRA consensus conference Open
Aims Recent trial data demonstrate beneficial effects of active rhythm management in patients with atrial fibrillation (AF) and support the concept that a low arrhythmia burden is associated with a low risk of AF-related complications. The…
View article: Development of Automated Neural Network Prediction for Echocardiographic Left ventricular Ejection Fraction
Development of Automated Neural Network Prediction for Echocardiographic Left ventricular Ejection Fraction Open
The echocardiographic measurement of left ventricular ejection fraction (LVEF) is fundamental to the diagnosis and classification of patients with heart failure (HF). In order to quantify LVEF automatically and accurately, this paper propo…
View article: Remote monitoring of atrial fibrillation recurrence using mHealth technology (REMOTE-AF)
Remote monitoring of atrial fibrillation recurrence using mHealth technology (REMOTE-AF) Open
Aims This proof-of-concept study sought to evaluate changes in heart rate (HR) obtained from a consumer wearable device and compare against implantable loop recorder (ILR)-detected recurrence of atrial fibrillation (AF) and atrial tachycar…
View article: Efficacy of decentralised home-based antihypertensive treatment in older adults with multimorbidity and polypharmacy (ATEMPT): an open-label randomised controlled pilot trial
Efficacy of decentralised home-based antihypertensive treatment in older adults with multimorbidity and polypharmacy (ATEMPT): an open-label randomised controlled pilot trial Open
National Institute for Health Research Oxford Biomedical Research Centre and the Oxford Martin School.
View article: Interactions of circulating, digoxin-like, steroids with rate control therapy for atrial fibrillation in the RATE-AF randomised clinical trial
Interactions of circulating, digoxin-like, steroids with rate control therapy for atrial fibrillation in the RATE-AF randomised clinical trial Open
Background Numerous endogenous cardiotonic steroids (CTS) similar to digoxin are thought to exist in humans, but this remains unproven and their clinical impact is unknown. Purpose To identify and quantify CTS in patients with atrial fibri…
View article: Unraveling the relationships between alpha- and beta-adrenergic modulation and the risk of heart failure
Unraveling the relationships between alpha- and beta-adrenergic modulation and the risk of heart failure Open
Background The effects of α and ß adrenergic receptor modulation on the risk of developing heart failure (HF) remains uncertain due to a lack of randomized controlled trials. This study aimed to estimate the effects of α and ß adrenergic r…
View article: A cardiotonic steroid multiplex method using ultra-high-performance liquid chromatography-tandem mass spectrometry
A cardiotonic steroid multiplex method using ultra-high-performance liquid chromatography-tandem mass spectrometry Open
Background and Aims Digoxin, a cardiotonic steroid (CTS), is commonly prescribed for patients with atrial fibrillation and heart failure. Endogenous CTS have been implicated in cardiovascular disease pathogenesis and can interact with digo…
View article: 2023 ESC Guidelines for the management of acute coronary syndromes
2023 ESC Guidelines for the management of acute coronary syndromes Open
Journal Article Corrected proof Guidelines 2023 ESC Guidelines for the management of acute coronary syndromes: Developed by the task force on the management of acute coronary syndromes of the European Society of Cardiology (ESC) Get access…