Dipanjan Banerjee
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View article: Targeting Cardiomyocyte PCNA and POLD1 Prevents Pathologic Myocardial Hypertrophy
Targeting Cardiomyocyte PCNA and POLD1 Prevents Pathologic Myocardial Hypertrophy Open
BACKGROUND: Activation of cell cycle regulatory pathways has been detected during pathological cardiomyocyte growth. However, it has remained unclear whether DNA synthesis pathways play a direct role in cardiomyocyte hypertrophy. We previo…
View article: Radiotherapy for Lung Cancer: An Unrecognized Cause of Lung Torsion
Radiotherapy for Lung Cancer: An Unrecognized Cause of Lung Torsion Open
Lung torsion is an exceptional occurrence, usually requiring urgent surgery because of vascular compromise. Because of the rarity and non-specific symptoms, it often requires clinicians to have a high degree of suspicion to make an early d…
View article: Macrophage foam cell-derived mediator promotes spontaneous fat lipolysis in atherosclerosis models
Macrophage foam cell-derived mediator promotes spontaneous fat lipolysis in atherosclerosis models Open
Ectopic lipid accumulation in macrophages is responsible for the formation of macrophage foam cells (MFCs) which are involved in the crosstalk with the perivascular adipose tissue (PVAT) of the vascular wall that plays a pivotal role in th…
View article: MDM2 Regulation of HIF Signaling Causes Microvascular Dysfunction in Hypertrophic Cardiomyopathy
MDM2 Regulation of HIF Signaling Causes Microvascular Dysfunction in Hypertrophic Cardiomyopathy Open
BACKGROUND: Microvasculature dysfunction is a common finding in pathologic remodeling of the heart and is thought to play an important role in the pathogenesis of hypertrophic cardiomyopathy (HCM), a disease caused by sarcomere gene mutati…
View article: Recent insights of obesity-induced gut and adipose tissue dysbiosis in type 2 diabetes
Recent insights of obesity-induced gut and adipose tissue dysbiosis in type 2 diabetes Open
An imbalance in microbial homeostasis, referred to as dysbiosis, is critically associated with the progression of obesity-induced metabolic disorders including type 2 diabetes (T2D). Alteration in gut microbial diversity and the abundance …
View article: The risks of rejection vs. infection: Ramsay Hunt syndrome, Gradenigo syndrome, and varicella meningoencephalitis in a heart transplant patient
The risks of rejection vs. infection: Ramsay Hunt syndrome, Gradenigo syndrome, and varicella meningoencephalitis in a heart transplant patient Open
Background Orthotopic heart transplant (OHT) recipients are at increased risk for varicella zoster reactivation, and severe complications may arise due to their immunosuppressive regimens. Managing immunosuppression in acute infection is d…
View article: Eosinophilic Myocarditis Presenting as Cardiac Tamponade: A Diagnostic Challenge
Eosinophilic Myocarditis Presenting as Cardiac Tamponade: A Diagnostic Challenge Open
Eosinophilic myocarditis (EM) is a rare cause of acute heart failure. It can occur secondary to drug hypersensitivity, autoimmune diseases such as vasculitis, idiopathic hypereosinophilic syndrome (HES) or malignancy, but is often under-re…
View article: Association between Subclinical Hypothyroidism and Incident Hypertension in Women: A Systematic Review and Meta-Analysis
Association between Subclinical Hypothyroidism and Incident Hypertension in Women: A Systematic Review and Meta-Analysis Open
Subclinical hypothyroidism (SCH) has been found to be associated with an increased risk of cardiovascular diseases. However, there is no clear consensus on the relationship between SCH and hypertension (HTN). We sought to investigate the a…
View article: The Role of 18F-Flortaucipir (AV-1451) in the Diagnosis of Neurodegenerative Disorders
The Role of 18F-Flortaucipir (AV-1451) in the Diagnosis of Neurodegenerative Disorders Open
Tau protein plays a vital role in maintaining the structural and functional integrity of the nervous system; however, hyperphosphorylation or abnormal phosphorylation of tau protein plays an essential role in the pathogenesis of several ne…
View article: Neuroimaging in Dementia With Lewy Bodies
Neuroimaging in Dementia With Lewy Bodies Open
Dementia with Lewy bodies (DLB) is one of the most common forms of dementia. It can present as neurocognitive decline, visual hallucinations, and concomitant symptoms of rapid eye movement (REM) sleep behavior disorder. Early diagnosis rem…
View article: Prescribing and monitoring high dose and combined antipsychotics in community mental health team
Prescribing and monitoring high dose and combined antipsychotics in community mental health team Open
Aims The aim was to establish the prevalence of prescription of combined and high dose antipsychotics in the community mental health team and to see if such patients were being offered regular monitoring as advised by NICE guidelines. Back…
View article: Fibroelastic Tissue Ring Causing ECMO Catheter Obstruction
Fibroelastic Tissue Ring Causing ECMO Catheter Obstruction Open
The Avalon Elite catheter (Maquet Cardiopulmonary, Rastatt, Germany) is a bicaval catheter for single-site cannulation that can be used in the initiation of venovenous extracorporeal membrane oxygenation (ECMO) or as a transition from veno…
View article: Parkinsonism: A Rare Adverse Effect of Valproic Acid
Parkinsonism: A Rare Adverse Effect of Valproic Acid Open
Valproic acid (VPA) is an anti-epileptic drug (AED) used as a first-choice agent for most forms of epilepsy. It is used in the treatment of manic episodes, bipolar disorder, migraine prevention, and impulse control. Hence it is one of the …
View article: Improving risk stratification in heart failure with preserved ejection fraction by combining two validated risk scores
Improving risk stratification in heart failure with preserved ejection fraction by combining two validated risk scores Open
Introduction The Intermountain Risk Score (IMRS) was developed and validated to predict short-term and long-term mortality in hospitalised patients using demographics and commonly available laboratory data. In this study, we sought to dete…
View article: Planned Concomitant Left and Right Ventricular Assist Device Insertion to Avoid Long-term Biventricular Mechanical Support: Bridge to Right Ventricular Recovery
Planned Concomitant Left and Right Ventricular Assist Device Insertion to Avoid Long-term Biventricular Mechanical Support: Bridge to Right Ventricular Recovery Open
Introduction: The planned use of a temporary right ventricular assist device (RVAD) at the time of left ventricular assist device (LVAD) implantation may prevent the need for a permanent biventricular assist device (BiVAD). Herein we descr…
View article: Optimal timing of same-admission orthotopic heart transplantation after left ventricular assist device implantation
Optimal timing of same-admission orthotopic heart transplantation after left ventricular assist device implantation Open
In this cohort of patients who received LVADs, the rate of in-hospital mortality after OHT was lower for patients who underwent late OHT (at least 8 d after LVAD implantation) compared to patients who underwent early OHT. Delayed timing of…
View article: Efficacy of Video Capsule Endoscopy in the Management of Suspected Small Bowel Bleeding in Patients With Continuous Flow Left Ventricular Assist Devices
Efficacy of Video Capsule Endoscopy in the Management of Suspected Small Bowel Bleeding in Patients With Continuous Flow Left Ventricular Assist Devices Open
We did not find VCE changed management or outcomes in CF-LVAD patients with suspected small bowel bleeding at our institution when compared to a non-VCE control group. Our experience is small and single center, and larger, multi-center stu…
View article: Simultaneous ramp right heart catheterization and echocardiography in a ReliantHeart left ventricular assist device
Simultaneous ramp right heart catheterization and echocardiography in a ReliantHeart left ventricular assist device Open
Many clinicians caring for patients with continuous flow left ventricular assist devices (CF-LVAD) use ramp right heart catheterization (RHC) studies to optimize pump speed and also to troubleshoot CF-LVAD malfunction. An investigational d…
View article: An informatics-based approach to reducing heart failure all-cause readmissions: the Stanford heart failure dashboard
An informatics-based approach to reducing heart failure all-cause readmissions: the Stanford heart failure dashboard Open
Background: Reduction of 30-day all-cause readmissions for heart failure (HF) has become an important quality-of-care metric for health care systems. Many hospitals have implemented quality improvement programs designed to reduce 30-day al…