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View article: Skin Allergy Research Society and Society for Eczema Studies Joint Task Force Guidelines of Care for Management of Atopic Dermatitis for Adults, Children, and Special Populations in India: An Evidence-Based Review and an Expert Consensus
Skin Allergy Research Society and Society for Eczema Studies Joint Task Force Guidelines of Care for Management of Atopic Dermatitis for Adults, Children, and Special Populations in India: An Evidence-Based Review and an Expert Consensus Open
Atopic dermatitis (AD) is a chronic inflammatory skin disease with significant morbidity. Recognising the need for region-specific guidance, the Skin Allergy Research Society and Society for Eczema Studies have collaborated to develop upda…
View article: C-MYC expression analysis by immunohistochemistry in cases of subcutaneous panniculitis T-cell lymphoma and lupus panniculitis
C-MYC expression analysis by immunohistochemistry in cases of subcutaneous panniculitis T-cell lymphoma and lupus panniculitis Open
Background Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is an uncommon cutaneous T-cell lymphoma commonly seen in middle-aged females. Lupus panniculitis (LP) is a close differential of SPTCL and the clinical, histological, and i…
View article: Standardized indirect immunofluorescence-based detection of dermal-binding autoantibodies in pemphigoid diseases: a prospective international multicentre study
Standardized indirect immunofluorescence-based detection of dermal-binding autoantibodies in pemphigoid diseases: a prospective international multicentre study Open
We evaluated a Biochip™-based immunofluorescence assay for improved diagnosis of dermal-binding pemphigoid diseases by detecting autoantibodies against laminin β4, type VII collagen and laminin 332. Results showed high sensitivity, with an…
View article: Influence of CD16 (FcγRIII) Expression on Peripheral Blood Mononuclear Cells on Response to Treatment with Rituximab in Pemphigus: A Cross-Sectional Study
Influence of CD16 (FcγRIII) Expression on Peripheral Blood Mononuclear Cells on Response to Treatment with Rituximab in Pemphigus: A Cross-Sectional Study Open
Background: Rituximab-mediated B-cell depletion in pemphigus patients is majorly caused by antibody-dependent cellular cytotoxicity. This is mediated by Fcγ receptors on immune cells, particularly FcγRIIIa (CD16) on natural killer (NK) cel…
View article: Comparison of anti-desmoglein antibodies titres and anti-M3 muscarinic acetylcholine receptor antibody titres as biomarker for potential pemphigus between subjects who are occupationally exposed and not exposed to pesticides
Comparison of anti-desmoglein antibodies titres and anti-M3 muscarinic acetylcholine receptor antibody titres as biomarker for potential pemphigus between subjects who are occupationally exposed and not exposed to pesticides Open
Background The pathogenesis of pemphigus is multifactorial, and pesticides have been implicated as one of the triggering factors due to their interaction with acetylcholine receptors. Aim The aim of this study was to observe the effect of …
View article: Lichen Planus Pemphigoides: A Clinical, Histopathological, and Immunological Report of 12 Indian Patients
Lichen Planus Pemphigoides: A Clinical, Histopathological, and Immunological Report of 12 Indian Patients Open
Background: Lichen planus pemphigoides (LPP) is a rare autoimmune subepidermal blistering disease presenting with lichenoid papules and plaques and tense blisters. There is a paucity of literature on LPP globally. Objective: To report the …
View article: Single nucleotide polymorphism of IGF-1R (rs2229765) in acne and/or its severity
Single nucleotide polymorphism of IGF-1R (rs2229765) in acne and/or its severity Open
Acne vulgaris is a common inflammatory disease of pilosebaceous glands diagnosed by dermatologists in teenagers. During puberty, a peak in the levels of hormones (growth factors and its terminal mediator insulin-like growth factor-1 (IGF-1…
View article: The deception of acantholysis: The painful and overlooked story of ocular surface squamous neoplasia in a red eye
The deception of acantholysis: The painful and overlooked story of ocular surface squamous neoplasia in a red eye Open
A painful red eye can be extremely distressing and can be caused by various ophthalmological or dermatological disorders. We hereby report a case of a red, painful eye in a 55-year-old woman suspected to have pemphigus or ocular cicatricia…
View article: Solitary verrucous plaque on a leg
Solitary verrucous plaque on a leg Open
We present the case of a female in her 70s who presented with a solitary verrucous plaque on her left leg accompanied by painful oral erosions. Various differential diagnoses were considered, like lichen simplex chronicus, hypertrophic lic…
View article: Efficacy and safety of azathioprine versus mycophenolate mofetil in chronic actinic dermatitis in skin of color: results of a randomized controlled trial
Efficacy and safety of azathioprine versus mycophenolate mofetil in chronic actinic dermatitis in skin of color: results of a randomized controlled trial Open
Introduction Chronic actinic dermatitis (CAD) is an immunologically mediated photodermatosis that has been effectively treated with azathioprine and mycophenolate mofetil (MMF) in uncontrolled studies. We conducted a prospective randomized…
View article: P018 Puzzling vesicles: a clinicopathological challenge
P018 Puzzling vesicles: a clinicopathological challenge Open
An 8-year-old male child presented with a history of multiple vesicles and bullae on the ear, nose, upper trunk, lower legs and feet for the past 4 years. There was no history of photosensitivity. There was no history of similar conditions…
View article: Pemphigus and Pregnancy
Pemphigus and Pregnancy Open
Pemphigus in pregnancy is a special clinical scenario that has potential consequences on both maternal and fetal outcomes. Being an autoimmune disease with Th2 preponderance, pemphigus is expected to flare in pregnancy, especially in the f…
View article: Construction and validation of an audio-visual tool to instruct caregivers of patients with pemphigus in photographing skin and oral cavity lesions during tele-consultation: A cross-sectional study
Construction and validation of an audio-visual tool to instruct caregivers of patients with pemphigus in photographing skin and oral cavity lesions during tele-consultation: A cross-sectional study Open
Background Owing to the lack of standardised audio-visual (A-V) instructions to take photographs, patients with pemphigus faced difficulties during tele-consultation in COVID-19 pandemic. Objective To construct and validate an A-V instruct…
View article: Association of Attention Deficit Hyperactivity Disorder with the Use of Oral Propranolol in Infantile Haemangiomas: An Ambispective Comparative Study
Association of Attention Deficit Hyperactivity Disorder with the Use of Oral Propranolol in Infantile Haemangiomas: An Ambispective Comparative Study Open
Previous studies have raised concerns about the effects of oral propranolol on the central nervous system in infants, the exact measure and mechanism and the long-term follow-up of which is less well studied. This was an ambispective compa…
View article: Clinico-Epidemiologic Profile of Non-Syndromic Congenital Ichthyosis – A Retrospective Chart Review of 107 Patients
Clinico-Epidemiologic Profile of Non-Syndromic Congenital Ichthyosis – A Retrospective Chart Review of 107 Patients Open
Background: Congenital ichthyoses are a rare Mendelian group of disorders affecting the integument with a heterogeneous clinical presentation amongst which scaling is a constant feature. There is scanty epidemiologic data regarding the cli…
View article: Facial Segmental Infantile Haemangioma: A Cutaneous Mosaicism Quandary
Facial Segmental Infantile Haemangioma: A Cutaneous Mosaicism Quandary Open
Mosaicism has long been considered the underlying mechanism of segmental infantile hemangiomas (SIH). This was a prospective pilot case-control study conducted with the objective to quantify the percentage overlap of silhouettes of facial …