Dipayan Bose
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View article: Novel small non-coding RNAs of Epstein-Barr virus upregulated upon lytic reactivation aid in viral genomic replication and virion production
Novel small non-coding RNAs of Epstein-Barr virus upregulated upon lytic reactivation aid in viral genomic replication and virion production Open
Epstein-Barr virus (EBV) employs various strategies for long-term survival, including the expression of non-coding RNAs (ncRNAs). This study uncovers and characterizes two novel EBV-encoded ncRNAs, p7 and p8, which are upregulated during l…
View article: Epigenetic and epitranscriptomic regulation during oncogenic γ-herpesvirus infection
Epigenetic and epitranscriptomic regulation during oncogenic γ-herpesvirus infection Open
Oncogenic gamma herpesviruses, including Epstein–Barr Virus (EBV) and Kaposi’s Sarcoma-associated Herpesvirus (KSHV), are opportunistic cancer-causing viruses and induces oncogenesis through complex mechanisms, which involves manipulation …
View article: The F-box E3 ligase protein FBXO11 regulates EBNA3C-associated degradation of BCL6
The F-box E3 ligase protein FBXO11 regulates EBNA3C-associated degradation of BCL6 Open
Most mature B-cell malignancies originate from the malignant transformation of germinal center (GC) B cells. The GC reaction appears to have a role in malignant transformation, in which a major player of the GC reaction is BCL6, a key regu…
View article: A minimal presynaptic protein machinery mediating synchronous and asynchronous exocytosis and short-term plasticity
A minimal presynaptic protein machinery mediating synchronous and asynchronous exocytosis and short-term plasticity Open
Neurotransmitters are released from synaptic vesicles with remarkable precision in response to presynaptic Ca2+ influx but exhibit significant heterogeneity in exocytosis timing and efficacy based on the recent history of activity. This he…
View article: A minimal presynaptic protein machinery mediating synchronous and asynchronous exocytosis and short-term plasticity
A minimal presynaptic protein machinery mediating synchronous and asynchronous exocytosis and short-term plasticity Open
Neurotransmitters are released from synaptic vesicles with remarkable precision in response to presynaptic Ca 2+ influx but exhibit significant heterogeneity in exocytosis timing and efficacy based on the recent history of activity. This h…
View article: KSHV-encoded LANA bypasses transcriptional block through the stabilization of RNA Pol II in hypoxia
KSHV-encoded LANA bypasses transcriptional block through the stabilization of RNA Pol II in hypoxia Open
Hypoxia results from an insufficient supply of oxygen, which results in physiological stress in biological systems. Cells respond to this unfavorable condition by reducing critical cellular functions, which include replication, transcripti…
View article: Attenuation of IFN signaling due to m6A modification of the host epitranscriptome promotes EBV lytic reactivation
Attenuation of IFN signaling due to m6A modification of the host epitranscriptome promotes EBV lytic reactivation Open
Background Reactivation of Epstein Barr virus (EBV) leads to modulation of the viral and cellular epitranscriptome. N6-methyladenosine (m 6 A) modification is a type of RNA modification that regulates metabolism of mRNAs. Previous reports …
View article: Epigenetic Reprogramming of Kaposi’s Sarcoma-Associated Herpesvirus during Hypoxic Reactivation
Epigenetic Reprogramming of Kaposi’s Sarcoma-Associated Herpesvirus during Hypoxic Reactivation Open
The biphasic life cycle (latent and lytic) of Kaposi’s sarcoma-associated Herpesvirus (KSHV) is regulated by epigenetic modification of its genome and its associated histone proteins. The temporal events driving epigenetic reprogramming of…
View article: Prognostic correlations with the microbiome of breast cancer subtypes
Prognostic correlations with the microbiome of breast cancer subtypes Open
Alterations to the natural microbiome are linked to different diseases, and the presence or absence of specific microbes is directly related to disease outcomes. We performed a comprehensive analysis with unique cohorts of the four subtype…
View article: KSHV-encoded vCyclin can modulate HIF1α levels to promote DNA replication in hypoxia
KSHV-encoded vCyclin can modulate HIF1α levels to promote DNA replication in hypoxia Open
The cellular adaptive response to hypoxia, mediated by high HIF1α levels includes metabolic reprogramming, restricted DNA replication and cell division. In contrast to healthy cells, the genome of cancer cells, and Kaposi’s sarcoma associa…
View article: HIF1α-Regulated Expression of the Fatty Acid Binding Protein Family Is Important for Hypoxic Reactivation of Kaposi’s Sarcoma-Associated Herpesvirus
HIF1α-Regulated Expression of the Fatty Acid Binding Protein Family Is Important for Hypoxic Reactivation of Kaposi’s Sarcoma-Associated Herpesvirus Open
Hypoxia is a detrimental stress to eukaryotes and inhibits several cellular processes, such as DNA replication, transcription, translation, and metabolism. Interestingly, the genome of Kaposi’s sarcoma-associated herpesvirus (KSHV) is know…
View article: Detection of Microbial Agents in Oropharyngeal and Nasopharyngeal Samples of SARS-CoV-2 Patients
Detection of Microbial Agents in Oropharyngeal and Nasopharyngeal Samples of SARS-CoV-2 Patients Open
The novel coronavirus outbreak started in December 2019 and rapidly spread around the globe, leading to a global pandemic. Here we reported the association of microbial agents identified in oropharyngeal and nasopharyngeal samples from pat…
View article: Vascular endothelial growth factor encoded by Parapoxviruses can regulate metabolism and survival of triple negative breast cancer cells
Vascular endothelial growth factor encoded by Parapoxviruses can regulate metabolism and survival of triple negative breast cancer cells Open
Dysbiotic microbiomes are linked to many pathological outcomes including different metabolic disorders like diabetes, atherosclerosis and even cancer. Breast cancer is the second leading cause of cancer associated death in women, and tripl…
View article: Field Configuration and Design of a New 14.4 GHz ECR Ion Source for the Superconducting Cyclotron under Construction
Field Configuration and Design of a New 14.4 GHz ECR Ion Source for the Superconducting Cyclotron under Construction Open
A new ECR ion source was designed by properly configuring the magnetic bottle long enough to confine a plasma of a desired heavy element for high charge state ion beams. The axial mirror-maxima of the magnetic field at the two ends were op…
View article: Heat Killed Attenuated Leishmania Induces Apoptosis of HepG2 Cells Through ROS Mediated p53 Dependent Mitochondrial Pathway
Heat Killed Attenuated Leishmania Induces Apoptosis of HepG2 Cells Through ROS Mediated p53 Dependent Mitochondrial Pathway Open
Background/Aims: Cytotoxic effect of attenuated Leishmania on liver cancer cells by inducing ROS generation. Methods: Spectrophotometric study to analyze cell death and levels of different active caspases. Flow cytometric study was done to…
View article: Lipid from Infective L. donovani Regulates Acute Myeloid Cell Growth via Mitochondria Dependent MAPK Pathway
Lipid from Infective L. donovani Regulates Acute Myeloid Cell Growth via Mitochondria Dependent MAPK Pathway Open
The microbial source, which includes live, attenuated, or genetically modified microbes or their cellular component(s) or metabolites, has gained increasing significance for therapeutic intervention against several pathophysiological condi…
View article: CCDC 1038199: Experimental Crystal Structure Determination
CCDC 1038199: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …