Diptiman Chanda
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View article: Small Extracellular Vesicle Signaling and Mitochondrial Transfer Reprograms T Helper Cell Function in Human Asthma
Small Extracellular Vesicle Signaling and Mitochondrial Transfer Reprograms T Helper Cell Function in Human Asthma Open
Small extracellular vesicles (sEVs) are known to orchestrate cell-cell communication, but the role of sEV signaling via mitochondria in perpetuating asthmatic airway inflammation is unknown. Myeloid-derived regulatory cells (MDRCs) are kno…
View article: Supplementary Data from Therapeutic Potential of Adult Bone Marrow–Derived Mesenchymal Stem Cells in Prostate Cancer Bone Metastasis
Supplementary Data from Therapeutic Potential of Adult Bone Marrow–Derived Mesenchymal Stem Cells in Prostate Cancer Bone Metastasis Open
Supplementary Data from Therapeutic Potential of Adult Bone Marrow–Derived Mesenchymal Stem Cells in Prostate Cancer Bone Metastasis
View article: Data from Therapeutic Potential of Adult Bone Marrow–Derived Mesenchymal Stem Cells in Prostate Cancer Bone Metastasis
Data from Therapeutic Potential of Adult Bone Marrow–Derived Mesenchymal Stem Cells in Prostate Cancer Bone Metastasis Open
Purpose: Current evidence indicates that an osteoblast lesion in prostate cancer is preceded by osteolysis. Thus, prevention of osteolysis would reduce complications of bone metastasis. Bone marrow–derived mesenchymal stem cells hav…
View article: Supplementary Data from Therapeutic Potential of Adult Bone Marrow–Derived Mesenchymal Stem Cells in Prostate Cancer Bone Metastasis
Supplementary Data from Therapeutic Potential of Adult Bone Marrow–Derived Mesenchymal Stem Cells in Prostate Cancer Bone Metastasis Open
Supplementary Data from Therapeutic Potential of Adult Bone Marrow–Derived Mesenchymal Stem Cells in Prostate Cancer Bone Metastasis
View article: Data from Therapeutic Potential of Adult Bone Marrow–Derived Mesenchymal Stem Cells in Prostate Cancer Bone Metastasis
Data from Therapeutic Potential of Adult Bone Marrow–Derived Mesenchymal Stem Cells in Prostate Cancer Bone Metastasis Open
Purpose: Current evidence indicates that an osteoblast lesion in prostate cancer is preceded by osteolysis. Thus, prevention of osteolysis would reduce complications of bone metastasis. Bone marrow–derived mesenchymal stem cells hav…
View article: Mitochondrial uncoupling protein‐2 reprograms metabolism to induce oxidative stress and myofibroblast senescence in age‐associated lung fibrosis
Mitochondrial uncoupling protein‐2 reprograms metabolism to induce oxidative stress and myofibroblast senescence in age‐associated lung fibrosis Open
Mitochondrial dysfunction has been associated with age‐related diseases, including idiopathic pulmonary fibrosis (IPF). We provide evidence that implicates chronic elevation of the mitochondrial anion carrier protein, uncoupling protein‐2 …
View article: Integrated bioinformatics analysis identifies established and novel TGFβ1-regulated genes modulated by anti-fibrotic drugs
Integrated bioinformatics analysis identifies established and novel TGFβ1-regulated genes modulated by anti-fibrotic drugs Open
View article: Mesenchymal stromal cell aging impairs the self-organizing capacity of lung alveolar epithelial stem cells
Mesenchymal stromal cell aging impairs the self-organizing capacity of lung alveolar epithelial stem cells Open
Multicellular organisms maintain structure and function of tissues/organs through emergent, self-organizing behavior. In this report, we demonstrate a critical role for lung mesenchymal stromal cell (L-MSC) aging in determining the capacit…
View article: Author response: Mesenchymal stromal cell aging impairs the self-organizing capacity of lung alveolar epithelial stem cells
Author response: Mesenchymal stromal cell aging impairs the self-organizing capacity of lung alveolar epithelial stem cells Open
Article Figures and data Abstract eLife digest Introduction Results and discussion Materials and methods Appendix 1 Data availability References Decision letter Author response Article and author information Metrics Abstract Multicellular …
View article: Mesenchymal Stromal Cell Aging Impairs the Self-Organizing Capacity of Lung Alveolar Epithelial Stem Cells
Mesenchymal Stromal Cell Aging Impairs the Self-Organizing Capacity of Lung Alveolar Epithelial Stem Cells Open
Multicellular organisms maintain structure and function of tissues/organs through emergent, self-organizing behavior. In this report, we demonstrate a critical role for lung mesenchymal stromal cell (L-MSC) aging in determining the capacit…
View article: Restoration of SIRT3 gene expression by airway delivery resolves age-associated persistent lung fibrosis in mice
Restoration of SIRT3 gene expression by airway delivery resolves age-associated persistent lung fibrosis in mice Open
View article: SIRT3 Promotes Resolution of Persistent Lung Fibrosis Associated with Aging
SIRT3 Promotes Resolution of Persistent Lung Fibrosis Associated with Aging Open
View article: Effects of Intereukin-6/JAK-STAT Pathway Blockade on Fibroblast Activation: Potential Role in Idiopathic Pulmonary Fibrosis
Effects of Intereukin-6/JAK-STAT Pathway Blockade on Fibroblast Activation: Potential Role in Idiopathic Pulmonary Fibrosis Open
View article: Modeling Fibrosis in Three-Dimensional Organoids Reveals New Epithelial Restraints on Fibroblasts
Modeling Fibrosis in Three-Dimensional Organoids Reveals New Epithelial Restraints on Fibroblasts Open
View article: Fgf10 Signaling in Lung Development, Homeostasis, Disease, and Repair After Injury
Fgf10 Signaling in Lung Development, Homeostasis, Disease, and Repair After Injury Open
The lung is morphologically structured into a complex tree-like network with branched airways ending distally in a large number of alveoli for efficient oxygen exchange. At the cellular level, the adult lung consists of at least 40-60 diff…
View article: Developmental pathways in the pathogenesis of lung fibrosis
Developmental pathways in the pathogenesis of lung fibrosis Open
View article: Unique Lipid Signatures of Extracellular Vesicles from the Airways of Asthmatics
Unique Lipid Signatures of Extracellular Vesicles from the Airways of Asthmatics Open
View article: Exosomal transfer of mitochondria from airway myeloid-derived regulatory cells to T cells
Exosomal transfer of mitochondria from airway myeloid-derived regulatory cells to T cells Open
Chronic inflammation involving both innate and adaptive immune cells is implicated in the pathogenesis of asthma. Intercellular communication is essential for driving and resolving inflammatory responses in asthma. Emerging studies suggest…
View article: Mesenchymal stem cells expressing osteoprotegerin variants inhibit osteolysis in a murine model of multiple myeloma
Mesenchymal stem cells expressing osteoprotegerin variants inhibit osteolysis in a murine model of multiple myeloma Open
Key Points The study developed a mouse model of bone disseminated myeloma disease as in humans. The study established therapeutic potential of OPG variants to revert myeloma bone damage in vivo.
View article: Fgf10-Hippo Epithelial-Mesenchymal Crosstalk Maintains and Recruits Lung Basal Stem Cells
Fgf10-Hippo Epithelial-Mesenchymal Crosstalk Maintains and Recruits Lung Basal Stem Cells Open
View article: Effects of Cellular Methylation on Transgene Expression and Site-Specific Integration of Adeno-Associated Virus
Effects of Cellular Methylation on Transgene Expression and Site-Specific Integration of Adeno-Associated Virus Open
DNA methylation is a major epigenetic event that affects not only cellular gene expression but that also has the potential to influence bacterial and viral DNA in their host-dependent functions. Adeno-associated virus (AAV) genome contains…
View article: Developmental Reprogramming in Mesenchymal Stromal Cells of Human Subjects with Idiopathic Pulmonary Fibrosis
Developmental Reprogramming in Mesenchymal Stromal Cells of Human Subjects with Idiopathic Pulmonary Fibrosis Open
View article: Breast Cancer Subtypes Predispose the Site of Distant Metastases
Breast Cancer Subtypes Predispose the Site of Distant Metastases Open
These findings further articulate that breast cancer subtypes differ not only in tumor characteristics but also in their metastatic behavior, thus raising the possibility that this knowledge could potentially be used in determining the app…
View article: Variants of Osteoprotegerin Lacking TRAIL Binding for Therapeutic Bone Remodeling in Osteolytic Malignancies
Variants of Osteoprotegerin Lacking TRAIL Binding for Therapeutic Bone Remodeling in Osteolytic Malignancies Open
Osteolytic bone damage is a major cause of morbidity in several metastatic pathologies. Current therapies using bisphosphonates provide modest improvement, but cytotoxic side effects still occur prompting the need to develop more effective…
View article: Endostatin: A novel inhibitor of androgen receptor function in prostate cancer
Endostatin: A novel inhibitor of androgen receptor function in prostate cancer Open
Significance Despite the development of second-generation androgen receptor (AR)-targeted therapies for castration-resistant prostate cancer (CRPC), the effects are only modest, compelling the need for novel therapy combinations that can m…