Dirk Czesnik
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View article: Men Show Reduced Cardiac Baroreceptor Sensitivity during Modestly Painful Electrical Stimulation of the Forearm: Exploratory Results from a Sham-Controlled Crossover Vagus Nerve Stimulation Study
Men Show Reduced Cardiac Baroreceptor Sensitivity during Modestly Painful Electrical Stimulation of the Forearm: Exploratory Results from a Sham-Controlled Crossover Vagus Nerve Stimulation Study Open
This paper presents data from a transcutaneous vagus nerve stimulation experiment that point towards a blunted cardiac baroreceptor sensitivity (cBRS) in young males compared to females during electrical stimulation of the forearm and a rh…
View article: Low Intensity, Transcranial, Alternating Current Stimulation Reduces Migraine Attack Burden in a Home Application Set-Up: A Double-Blinded, Randomized Feasibility Study
Low Intensity, Transcranial, Alternating Current Stimulation Reduces Migraine Attack Burden in a Home Application Set-Up: A Double-Blinded, Randomized Feasibility Study Open
Background: Low intensity, high-frequency transcranial alternating current stimulation (tACS) applied over the motor cortex decreases the amplitude of motor evoked potentials. This double-blind, placebo-controlled parallel group study aime…
View article: Synergistic PXT3003 therapy uncouples neuromuscular function from dysmyelination in male Charcot–Marie–Tooth disease type 1A (CMT1A) rats
Synergistic PXT3003 therapy uncouples neuromuscular function from dysmyelination in male Charcot–Marie–Tooth disease type 1A (CMT1A) rats Open
Charcot–Marie–Tooth disease 1 A (CMT1A) is caused by an intrachromosomal duplication of the gene encoding for PMP22 leading to peripheral nerve dysmyelination, axonal loss, and progressive muscle weakness. No therapy is available. PXT3003 …
View article: <i>I</i><sub>h</sub> contributes to increased motoneuron excitability in restless legs syndrome
<i>I</i><sub>h</sub> contributes to increased motoneuron excitability in restless legs syndrome Open
Key points Restless legs patients complain about sensory and motor symptoms leading to sleep disturbances. Symptoms include painful sensations, an urge to move and involuntary leg movements. The responsible mechanisms of restless legs synd…
View article: Paired associative stimulation goes spinal
Paired associative stimulation goes spinal Open
Efficiency, reliability and reproducibility of transcranial stimulation (TS) protocols have been refined repeatedly in the past and will continue to be in the future. In clinical application, the most successful application so far has been…
View article: Biomarkers predict outcome in Charcot-Marie-Tooth disease 1A
Biomarkers predict outcome in Charcot-Marie-Tooth disease 1A Open
In summary, we provide evidence that cutaneous transcripts in patients with CMT1A serve as disease severity and progression biomarkers and, if implemented into clinical trials, they could markedly accelerate the development of a therapy fo…
View article: Increased HCN channel driven inward rectification in benign cramp fasciculation syndrome
Increased HCN channel driven inward rectification in benign cramp fasciculation syndrome Open
Muscle cramps are a common complaint associated with sudden painful involuntary contractions of a muscle. The mechanisms responsible for muscle cramps are still not clear. Axonal excitability and multi-unit electromyography studies were pe…
View article: Prophylactic treatment in menstrual migraine: A proof-of-concept study
Prophylactic treatment in menstrual migraine: A proof-of-concept study Open
The present study aimed to investigate the efficacy of repetitive cathodal direct current stimulation (rctDCS) over the visual cortex as a prophylactic treatment in patients with menstrual migraine. 20 female patients were recruited in thi…