Dirk Mossmann
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View article: Elevated arginine levels in liver tumors promote metabolic reprogramming and tumor growth
Elevated arginine levels in liver tumors promote metabolic reprogramming and tumor growth Open
Arginine auxotropy, due to reduced expression of urea cycle genes, is common in cancer. However, little is known about the levels of arginine in these cancers. Here, we report that arginine levels are elevated in hepatocellular carcinoma (…
View article: The novel mitochondrial matrix protease Ste23 is required for efficient presequence degradation and processing
The novel mitochondrial matrix protease Ste23 is required for efficient presequence degradation and processing Open
Approximately 70% of mitochondrial precursor proteins are imported from the cytosol via N-terminal presequences, which are cleaved upon exposure to the mitochondrial processing protease MPP in the matrix. Cleaved presequence peptides then …