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View article: 8277869 Trajectories of occupational exposure to welding fumes and its impact on lung cancer risks: A latent class modelling approach
8277869 Trajectories of occupational exposure to welding fumes and its impact on lung cancer risks: A latent class modelling approach Open
View article: Evaluation of lung cancer early detection offered by the German Social Accident Insurance for formerly asbestos-exposed employees using low-dose computed tomography – setting and study design
Evaluation of lung cancer early detection offered by the German Social Accident Insurance for formerly asbestos-exposed employees using low-dose computed tomography – setting and study design Open
Background Clinical trials have shown the benefits of lung cancer screening (LCS) in certain high-risk groups using low-dose high-resolution computed tomography (LDCT). Risk groups are usually defined by age and tobacco use. Exposure to as…
View article: Analysis of Recognized Occupational Infectious Diseases in Germany Between 2018 and 2023
Analysis of Recognized Occupational Infectious Diseases in Germany Between 2018 and 2023 Open
Objective Occupational infections pose substantial health risks across various professional sectors. Understanding their precise diagnoses, severity and distribution among different occupations is crucial for effective prevention. Methods …
View article: Bland–Altman Plot for Censored Variables
Bland–Altman Plot for Censored Variables Open
The comparison of two measurement methods turns out to be a statistical challenge if some of the observations are below the limit of quantification or detection. Here we show how the Bland–Altman plot can be modified for censored variables…
View article: Occupational Respirable Crystalline Silica Dust Exposure and Risk of Non–Lung Cancer Mortality Among German Uranium Miners (1946–2018)
Occupational Respirable Crystalline Silica Dust Exposure and Risk of Non–Lung Cancer Mortality Among German Uranium Miners (1946–2018) Open
Objective This study examines the relationship between occupational exposure to respirable crystalline silica dust and mortality from non–lung cancer diseases in German uranium miners. Methods Excess relative risk (ERR) for mortality from …
View article: Changes in mental distress among employees during the three years of the COVID-19 pandemic in Germany
Changes in mental distress among employees during the three years of the COVID-19 pandemic in Germany Open
Objectives The COVID-19 pandemic changed the future of work sustainably and led to a general increase in mental stress. A study conducted during the second and third pandemic wave with a retrospective survey of the first wave among 1,545 n…
View article: Combination of calretinin, MALAT1, and GAS5 as a potential prognostic biomarker to predict disease progression in surgically treated mesothelioma patients
Combination of calretinin, MALAT1, and GAS5 as a potential prognostic biomarker to predict disease progression in surgically treated mesothelioma patients Open
MALAT1, GAS5, and calretinin could be potential biomarkers for the prediction of tumor recurrence, improving the benefit from multimodal treatment including cytoreductive surgery.
View article: Club cell protein (CC16) in serum as an effect marker for small airway epithelial damage caused by diesel exhaust and blasting fumes in potash mining
Club cell protein (CC16) in serum as an effect marker for small airway epithelial damage caused by diesel exhaust and blasting fumes in potash mining Open
Objective The effect marker club cell protein (CC16) is secreted by the epithelium of the small respiratory tract into its lumen and passes into the blood. Increased amounts of CC16 in serum are observed during acute epithelial lung injury…
View article: Tasks and Experiences of the Prospective, Longitudinal, Multicenter MoMar (Molecular Markers) Study for the Early Detection of Mesothelioma in Individuals Formerly Exposed to Asbestos Using Liquid Biopsies
Tasks and Experiences of the Prospective, Longitudinal, Multicenter MoMar (Molecular Markers) Study for the Early Detection of Mesothelioma in Individuals Formerly Exposed to Asbestos Using Liquid Biopsies Open
Mesothelioma is an aggressive cancer, strongly associated with prior exposure to asbestos. Commonly, tumors are detected at late stages of the disease. Detection at early stages might be meaningful, because therapies might be more effectiv…
View article: Biomonitoring of polycyclic aromatic hydrocarbons in firefighters at fire training facilities and in employees at respiratory protection and hose workshops
Biomonitoring of polycyclic aromatic hydrocarbons in firefighters at fire training facilities and in employees at respiratory protection and hose workshops Open
Introduction Polycyclic aromatic hydrocarbons (PAHs) are carcinogenic to humans and are formed by incomplete combustion. PAHs are always present during firefighting operations, and fire department members can be exposed to them in the work…
View article: Exposure to polycyclic aromatic hydrocarbons assessed by biomonitoring of firefighters during fire operations in Germany
Exposure to polycyclic aromatic hydrocarbons assessed by biomonitoring of firefighters during fire operations in Germany Open
Under study conditions, properly applied protective clothing and wearing of SCBA led to a significant reduction of PAH exposure levels. But there are individual situations in which PAH are increasingly incorporated since the incorporation …
View article: Mesothelin Gene Variants Affect Soluble Mesothelin-Related Protein Levels in the Plasma of Asbestos-Exposed Males and Mesothelioma Patients from Germany
Mesothelin Gene Variants Affect Soluble Mesothelin-Related Protein Levels in the Plasma of Asbestos-Exposed Males and Mesothelioma Patients from Germany Open
Malignant mesothelioma (MM) is a severe disease mostly caused by asbestos exposure. Today, one of the best available biomarkers is the soluble mesothelin-related protein (SMRP), also known as mesothelin. Recent studies have shown that meso…
View article: Impact of occupational SARS-CoV-2 risk on the mental distress of non-healthcare employees in Germany
Impact of occupational SARS-CoV-2 risk on the mental distress of non-healthcare employees in Germany Open
Background The SARS-CoV-2 pandemic posed major challenges to employees and companies. Differences between industries and professions in occupational SARS-CoV-2 infection risk (OSIR) became apparent early on. This study examines the mental …
View article: Exploring solid-phase proximity ligation assay for survivin detection in urine
Exploring solid-phase proximity ligation assay for survivin detection in urine Open
Urine-based biomarkers are a rational and promising approach for the detection of bladder cancer due to the proximity of urine to the location of the tumor site and the non-invasive nature of its sampling. A well-known and highly investiga…
View article: Altered Mental Distress Among Employees From Different Occupational Groups and Industries During the COVID-19 Pandemic in Germany
Altered Mental Distress Among Employees From Different Occupational Groups and Industries During the COVID-19 Pandemic in Germany Open
Objective Mental distress of employees from the financial, public transport, public service, and industrial sector was examined in a cross-sectional study during the second COVID-19 (coronavirus disease 2019) wave in Germany and retrospect…
View article: Lung cancer and mesothelioma risks in a prospective cohort of workers with asbestos‐related lung or pleural diseases
Lung cancer and mesothelioma risks in a prospective cohort of workers with asbestos‐related lung or pleural diseases Open
Background Asbestos causes mesothelioma and lung cancer. In the European Union, asbestos was banned in 2005, but it is still in use in many other countries. The aim of this study was to estimate the lung cancer and mesothelioma incidence r…
View article: Underground salt and potash workers exposed to nitrogen oxides and diesel exhaust: assessment of specific effect biomarkers
Underground salt and potash workers exposed to nitrogen oxides and diesel exhaust: assessment of specific effect biomarkers Open
Purpose Occupational exposure limits (OEL) for nitrogen oxides (NO, NO 2 ) and diesel exhaust (EC-DPM) were reassessed by the German authorities in 2016/2017. We performed a clinical cross-sectional study among salt and potash underground …
View article: The German Uranium Miners’ Biobank—A Biobank for OMICs Radiation Research
The German Uranium Miners’ Biobank—A Biobank for OMICs Radiation Research Open
Systematic bio- and databanks are key prerequisites for modern radiation research to investigate radiation response mechanisms in the context of genetic, environmental and lifestyle-associated factors. This report presents the current stat…
View article: Nitrogen Oxides and Diesel Exhaust in the Underground Salt and Potash Mining – A clinical epidemiological Health Study
Nitrogen Oxides and Diesel Exhaust in the Underground Salt and Potash Mining – A clinical epidemiological Health Study Open
View article: A nationwide program for lung cancer screening by low-dose CT among formerly asbestos-exposed workers in Germany: concept and participation
A nationwide program for lung cancer screening by low-dose CT among formerly asbestos-exposed workers in Germany: concept and participation Open
View article: Studie zur Umsetzung und Akzeptanz des SARSCoV- 2-Arbeitsschutzstandards und der SARS-CoV-2- Arbeitsschutzregel fur einen erfolgreichen Infektionsschutz im Unternehmen
Studie zur Umsetzung und Akzeptanz des SARSCoV- 2-Arbeitsschutzstandards und der SARS-CoV-2- Arbeitsschutzregel fur einen erfolgreichen Infektionsschutz im Unternehmen Open
Study of the implementation and acceptance of the SARS-CoV-2 occupational safety and health standard and the SARS-CoV-2 occupational safety and health rules for successful infection control in companies Objectives: This study is intended t…
View article: How to Reduce the Exposure of Welders to an Acceptable Level: Results of the InterWeld Study
How to Reduce the Exposure of Welders to an Acceptable Level: Results of the InterWeld Study Open
Objectives Workplace measurements in the past have shown that the applicable occupational exposure limits (OELs) are regularly exceeded in practice when high-emission welding processes are applied. The InterWeld pilot study was planned as …
View article: Das Krebsrisiko von Feuerwehreinsatzkräften – Ein systematisches Review und Metaanalyse epidemiologischer Studien
Das Krebsrisiko von Feuerwehreinsatzkräften – Ein systematisches Review und Metaanalyse epidemiologischer Studien Open
The cancer risk of firefighters – a systematic review and meta-analysis of epidemiological studies Objectives: The aim of this study was to investigate the general and specific cancer risk of firefighters by taking different types of study…
View article: Re-evaluation of potential predictors of calretinin and mesothelin in a population-based cohort study using assays for the routine application in clinical medicine
Re-evaluation of potential predictors of calretinin and mesothelin in a population-based cohort study using assays for the routine application in clinical medicine Open
Objectives Calretinin and mesothelin are molecular markers for the detection of malignant mesothelioma at early stages. Our objective was the re-evaluation of factors influencing calretinin and mesothelin concentrations in plasma of cancer…
View article: Author’s reply to: cancer risks of firefighters: a systematic review and meta‑analysis of secular trends and region‑specific differences
Author’s reply to: cancer risks of firefighters: a systematic review and meta‑analysis of secular trends and region‑specific differences Open
View article: Association of exposure to manganese and fine motor skills in welders - Results from the WELDOX II study
Association of exposure to manganese and fine motor skills in welders - Results from the WELDOX II study Open
View article: Determinants of plasma calretinin in patients with malignant pleural mesothelioma
Determinants of plasma calretinin in patients with malignant pleural mesothelioma Open
View article: PhD program “Epidemiology & Clinical Research” at the University Hospital Essen
PhD program “Epidemiology & Clinical Research” at the University Hospital Essen Open
Since 2017, applicants with an academic degree in natural sciences or in the field of “life sciences” have the opportunity to participate in the three years international PhD program “Epidemiology & Clinical Research” at the University of …
View article: Circulating long non-coding RNA GAS5 (growth arrest-specific transcript 5) as a complement marker for the detection of malignant mesothelioma using liquid biopsies
Circulating long non-coding RNA GAS5 (growth arrest-specific transcript 5) as a complement marker for the detection of malignant mesothelioma using liquid biopsies Open
View article: Cancer risks of firefighters: a systematic review and meta-analysis of secular trends and region-specific differences
Cancer risks of firefighters: a systematic review and meta-analysis of secular trends and region-specific differences Open