Dirk Vanderschueren
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View article: SAT-156 Associations of Testosterone, Dihydrotestosterone and Sex Hormone-binding Globulin with Risks of Cancer Death, Incident Cancer, and Incident Prostate Cancer in Men. Individual Participant Data Meta-analyses
SAT-156 Associations of Testosterone, Dihydrotestosterone and Sex Hormone-binding Globulin with Risks of Cancer Death, Incident Cancer, and Incident Prostate Cancer in Men. Individual Participant Data Meta-analyses Open
Disclosure: R.J. Marriott: None. K. Murray: None. L. Antonio: None. S. Bhasin: None. A.S. Dobs: None. L. Flicker: None. D.J. Handelsman: None. G.J. Hankey: None. R. Wilkening: None. A.M. Matsumoto: None. C. Ohlsson: None. E.S. Orwoll: None…
View article: SAT-165 Directly Measured Free Testosterone May Better Predict Sexual Symptoms of Androgen Deficiency Than Calculated Free Testosterone Levels
SAT-165 Directly Measured Free Testosterone May Better Predict Sexual Symptoms of Androgen Deficiency Than Calculated Free Testosterone Levels Open
Disclosure: J. Walravens: None. N. Narinx: None. T. Reyns: None. D.M. Vanderschueren: None. F.C. Wu: None. T. Fiers: None. L. Antonio: None. J. Kaufman: None. B. Lapauw: None. Introduction: Guidelines suggest determination of serum free te…
View article: LOW 25-HYDROXY-VITAMIN D3 CONCENTRATIONS ARE ASSOCIATED WITH SEXUAL SYMPTOMS IN MIDDLE-AGED AND OLDER MEN
LOW 25-HYDROXY-VITAMIN D3 CONCENTRATIONS ARE ASSOCIATED WITH SEXUAL SYMPTOMS IN MIDDLE-AGED AND OLDER MEN Open
Objectives Several observational studies have linked vitamin D to cardiovascular health. Through its role in nitric oxide production in the vascular epithelium, vitamin D metabolites mediate endothelial function and can as such play an imp…
View article: ASSESSMENT OF MALE ANDROGEN EXPOSURE: A SURVEY ON MEASUREMENT AND REPORTING OF TOTAL TESTOSTERONE, SEX HORMONE-BINDING GLOBULIN, AND FREE TESTOSTERONE IN CLINICAL LABORATORIES ACROSS EUROPE
ASSESSMENT OF MALE ANDROGEN EXPOSURE: A SURVEY ON MEASUREMENT AND REPORTING OF TOTAL TESTOSTERONE, SEX HORMONE-BINDING GLOBULIN, AND FREE TESTOSTERONE IN CLINICAL LABORATORIES ACROSS EUROPE Open
Objectives The evaluation of male hypogonadism encompasses clinical parameters and biochemical measures of total testosterone (T), sex hormone-binding globulin (SHBG), and free T. Laboratory standardization is however lacking, leading to m…
View article: Sociodemographic, lifestyle, and medical factors associated with calculated free testosterone concentrations in men: individual participant data meta-analyses
Sociodemographic, lifestyle, and medical factors associated with calculated free testosterone concentrations in men: individual participant data meta-analyses Open
sponsorship: This work was funded by research grants from the Australian Government's Medical Research Future Fund, the Government of Western Australia's Future Health and Research Innovation Fund, the University Hospitals of Leuven, UZ Le…
View article: Determination of Androgen Bioactivity by an In Vitro Assay During Pubertal Transition in Healthy Boys
Determination of Androgen Bioactivity by an In Vitro Assay During Pubertal Transition in Healthy Boys Open
Objective To describe the bioactivity of circulating androgens during pubertal transition as determined by an in vitro bioassay assessing androgen receptor (AR) activation, and to compare these findings with circulating concentrations of t…
View article: A survey on measurement and reporting of total testosterone, sex hormone-binding globulin and free testosterone in clinical laboratories in Europe
A survey on measurement and reporting of total testosterone, sex hormone-binding globulin and free testosterone in clinical laboratories in Europe Open
Objectives To compare clinical laboratory workflows for the assessment of androgens in men, focusing on total testosterone (T), sex hormone-binding globulin (SHBG) and free T, in clinical laboratories throughout Europe. Methods An internet…
View article: Sociodemographic, lifestyle, and medical factors associated with calculated free testosterone concentrations in men: individual participant data meta-analyses
Sociodemographic, lifestyle, and medical factors associated with calculated free testosterone concentrations in men: individual participant data meta-analyses Open
OBJECTIVE: Sociodemographic, lifestyle, and medical variables influence total testosterone (T) and sex hormone-binding globulin (SHBG) concentrations. The relationship between these factors and "free" T remains unclear. We examined 21 soci…
View article: Sociodemographic, lifestyle, and medical factors associated with calculated free testosterone concentrations in men: individual participant data meta-analyses
Sociodemographic, lifestyle, and medical factors associated with calculated free testosterone concentrations in men: individual participant data meta-analyses Open
Objective Sociodemographic, lifestyle, and medical variables influence total testosterone (T) and sex hormone-binding globulin (SHBG) concentrations. The relationship between these factors and “free” T remains unclear. We examined 21 socio…
View article: Associations of Serum Testosterone and SHBG With Incident Fractures in Middle-aged to Older Men
Associations of Serum Testosterone and SHBG With Incident Fractures in Middle-aged to Older Men Open
Context As men age, circulating testosterone (T) decreases, circulating SHBG increases, and the risk of fracture increases. It is unclear if circulating T, independently of comorbidities, is associated with fracture risk in men. Objectives…
View article: 8377 Associations of Serum Testosterone and Sex Hormone-Binding Globulin with Incident Fractures in Middle-Aged to Older Men
8377 Associations of Serum Testosterone and Sex Hormone-Binding Globulin with Incident Fractures in Middle-Aged to Older Men Open
Disclosure: L. Grahnemo: None. R.J. Marriott: None. K. Murray: None. L. Tyack: None. M. Nethander: None. A.M. Matsumoto: None. E.S. Orwoll: None. D. Vanderschueren: None. B.B. Yeap: None. C. Ohlsson: None. As men age, their circulating tes…
View article: High-dose vitamin D supplementation does not improve outcome in a cutaneous melanoma population: results of a randomized double-blind placebo-controlled study (ViDMe trial)
High-dose vitamin D supplementation does not improve outcome in a cutaneous melanoma population: results of a randomized double-blind placebo-controlled study (ViDMe trial) Open
Background Observational studies in cutaneous melanoma (CM) have indicated an inverse relationship between levels of 25-hydroxyvitamin D and Breslow thickness, in addition to a protective effect of high 25-hydroxyvitamin D levels on clinic…
View article: Associations of Testosterone and Related Hormones With All-Cause and Cardiovascular Mortality and Incident Cardiovascular Disease in Men
Associations of Testosterone and Related Hormones With All-Cause and Cardiovascular Mortality and Incident Cardiovascular Disease in Men Open
Medical Research Future Fund, Government of Western Australia, and Lawley Pharmaceuticals. (PROSPERO: CRD42019139668).
View article: Insulin-like peptide 3 (INSL3) as an indicator of leydig cell insufficiency (LCI) in Middle-aged and older men with hypogonadism: reference range and threshold
Insulin-like peptide 3 (INSL3) as an indicator of leydig cell insufficiency (LCI) in Middle-aged and older men with hypogonadism: reference range and threshold Open
Insulin-like peptide 3 (INSL3) is a circulating biomarker for Leydig cell functional capacity in men, also indicating Leydig Cell Insufficiency (LCI) and potential primary hypogonadism. Using results from large cohort studies we explore so…
View article: Clinical and genetic determinants of vitamin D receptor expression in cutaneous melanoma patients
Clinical and genetic determinants of vitamin D receptor expression in cutaneous melanoma patients Open
Decrease of vitamin D receptor (VDR) expression is observed in melanocytic naevi and melanoma compared to normal skin. Little is known about factors influencing VDR expression in cutaneous melanoma (CM). We investigated the correlation of …
View article: Does testosterone influence the association between sleep and frailty in men: results from the European Male Aging Study
Does testosterone influence the association between sleep and frailty in men: results from the European Male Aging Study Open
Background Previous studies have suggested an association between sleep disturbance and frailty. The mechanism is unknown, although it has been suggested that hormonal factors may play a role. Methods The aim was to determine the associati…
View article: Issue Information
Issue Information Open
Wiley's Corporate Citizenship initiative seeks to address the environmental, social, economic, and ethical challenges faced in our business and which are important to our diverse stakeholder groups.Since launching the initiative, we have f…
View article: Hyponatremia, hypernatremia and impairment of functional, psychological and sexual domains
Hyponatremia, hypernatremia and impairment of functional, psychological and sexual domains Open
Objective To determine the influence of serum sodium on physical, psychologic and sexual function. Methods This is a cross-sectional survey on 3340 community-dwelling men aged 40–79 years from a prospective cohort study in eight European c…
View article: FRI475 The Impact Of Suppression Of Androgen Signaling On Thyroid Hormone Homeostasis In Prostate Cancer Patients
FRI475 The Impact Of Suppression Of Androgen Signaling On Thyroid Hormone Homeostasis In Prostate Cancer Patients Open
Disclosure: K. David: None. G. Devos: None. W. Devlies: None. N. Narinx: None. L. Antonio: None. L. Deboel: None. D. Schollaert: None. D.M. Vanderschueren: None. F.A. Claessens: None. S. Joniau: None. B. Decallonne: None. Next to the class…
View article: OR25-04 Factors Affecting Testosterone Concentrations In Men: Individual Participant Data Meta-analyses From The Androgens In Men Study
OR25-04 Factors Affecting Testosterone Concentrations In Men: Individual Participant Data Meta-analyses From The Androgens In Men Study Open
Disclosure: R.J. Marriott: None. K. Murray: None. L. Antonio: None. S. Bhasin: None. A.S. Dobs: None. D.J. Handelsman: None. G.J. Hankey: None. R. Haring: None. A.M. Matsumoto: None. C. Ohlsson: None. E.S. Orwoll: None. D.M. Vanderschueren…
View article: THU652 Associations Of Testosterone, Dihydrotestosterone, Estradiol And Sex Hormone-binding Globulin With All-cause And Cardiovascular Mortality, And Incident Cardiovascular Events In Men: Individual Participant Data Meta-analyses
THU652 Associations Of Testosterone, Dihydrotestosterone, Estradiol And Sex Hormone-binding Globulin With All-cause And Cardiovascular Mortality, And Incident Cardiovascular Events In Men: Individual Participant Data Meta-analyses Open
Disclosure: B.B. Yeap: None. R.J. Marriott: None. L. Antonio: None. S. Bhasin: None. A.S. Dobs: None. D.J. Handelsman: None. G.J. Hankey: None. R. Haring: None. A.M. Matsumoto: None. C. Ohlsson: None. E.S. Orwoll: None. D.M. Vanderschueren…
View article: Number of CAG repeats and mortality in middle aged and older men
Number of CAG repeats and mortality in middle aged and older men Open
Design The androgen receptor (AR) mediates peripheral effects of testosterone. Previous data suggests an association between the number of CAG repeats in exon‐1 of the AR gene and AR transcriptional activity. The aim of this analysis was t…
View article: Factors Associated With Circulating Sex Hormones in Men
Factors Associated With Circulating Sex Hormones in Men Open
Medical Research Future Fund, Government of Western Australia, and Lawley Pharmaceuticals. (PROSPERO: CRD42019139668).
View article: Methodological aspects of <i>in vivo</i> axial loading in rodents: a systematic review.
Methodological aspects of <i>in vivo</i> axial loading in rodents: a systematic review. Open
Axial loading in rodents provides a controlled setting for mechanical loading, because load and subsequent strain, frequency, number of cycles and rest insertion between cycles, are precisely defined. These methodological aspects as well a…