Ditte Olsen
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View article: Reshaping the progranulin/sortilin interaction for targeted degradation of extracellular proteins
Reshaping the progranulin/sortilin interaction for targeted degradation of extracellular proteins Open
Targeted protein degradation (TPD) using PROteolysis TArgeting Chimeras (PROTACs) is a rapidly emerging therapeutic strategy for difficult-to-drug cytosolic proteins. PROTACs are heterobifunctional small molecules that bridge the target wi…
Proprotein convertase subtilisin/kexin type 9 targets megalin in the kidney proximal tubule and aggravates proteinuria in nephrotic syndrome Open
Proteinuria is a prominent feature of chronic kidney disease. Interventions that reduce proteinuria slow the progression of chronic kidney disease and the associated risk of cardiovascular disease. Here, we propose a mechanistic coupling b…
View article: PCSK9 deficiency alters brain lipid composition without affecting brain development and function
PCSK9 deficiency alters brain lipid composition without affecting brain development and function Open
PCSK9 induces lysosomal degradation of the low-density lipoprotein (LDL) receptor (LDLR) in the liver, hereby preventing removal of LDL cholesterol from the circulation. Accordingly, PCSK9 inhibitory antibodies and siRNA potently reduce LD…
Loss of SORCS2 is associated with neuronal DNA double-strand breaks Open
SORCS2 is one of five proteins that constitute the Vps10p-domain receptor family. Members of this family play important roles in cellular processes linked to neuronal survival, differentiation and function. Genetic and functional studies i…
Altered dopaminergic firing pattern and novelty response underlie ADHD-like behavior of SorCS2-deficient mice Open
Attention deficit hyperactivity disorder (ADHD) is the most frequently diagnosed neurodevelopmental disorder worldwide. Affected individuals present with hyperactivity, inattention, and cognitive deficits and display a characteristic parad…
Glucagon-Like Peptide-2 Analogue ZP1849 Augments Colonic Anastomotic Wound Healing Open
Background . The enteroendocrine hormone glucagon-like peptide- (GLP-) 2 is a potent trophic factor in the gastrointestinal tract. The GLP-2 receptor (GLP-2R) is expressed in the stroma of the large bowel wall, which is the major therapeut…
Reduced Alcohol Seeking and Withdrawal Symptoms in Mice Lacking the BDNF Receptor SorCS2 Open
Alcohol use disorder (AUD) is characterized by repetitive and uncontrolled intake of alcohol with severe consequences for affected individuals, their families and society as a whole. Numerous studies have implicated brain-derived neurotrop…
Risk Locus Identification Ties Alcohol Withdrawal Symptoms to<i><span>SORCS</span>2</i> Open
Background Efforts to promote the cessation of harmful alcohol use are hindered by the affective and physiological components of alcohol withdrawal ( AW ), which can include life‐threatening seizures. Although previous studies of AW and re…
View article: Heparan sulfate proteoglycans present PCSK9 to the LDL receptor
Heparan sulfate proteoglycans present PCSK9 to the LDL receptor Open
Coronary artery disease is the main cause of death worldwide and accelerated by increased plasma levels of cholesterol-rich low-density lipoprotein particles (LDL). Circulating PCSK9 contributes to coronary artery disease by inducing lysos…
Detection of phosphorylated Akt and MAPK in cell culture assays Open
This article describes an immunocytochemistry (ICC) method for staining against phosphorylated forms of the kinases Akt (pAkt) and MAPK (pMAPK). Phosphorylation is induced upon their activation by a number stimuli including insulin and bra…