Explanipedia

Cryopreservation of Hematopoietic Stem Cells for Pediatric Autologous Stem Cell Transplantation Open

Rasika Setia, Mitu Dogra, Sanjeev Kumar Sharma, Divya Doval · 2024

A BSTRACT Background and Objectives: Dimethylsulfoxide(DMSO) is gold standard for cryopreservation of hematopoietic progenitor cells (HPC) to reconstitute hematopoiesis in autologous stem cell transplants (auto-HSCT). Higher DMSO-related a…

Treatment of newly diagnosed paediatric acute lymphoblastic leukaemia on BFM-based chemotherapy protocol: Feasibility and outcome from a tertiary care center in India Open

Vipin Khandelwal, Dharma Choudhary, Sanjeev Sharma, Divya Doval, Anil Handoo , et al. · 2023

Background: Data on outcomes in children with acute lymphoblastic leukaemia (ALL) who are on Berlin-Frankfurt-Munster (BFM)-based chemotherapy protocol is scarce from India. We share experience on the survival of children with ALL treated …

Allogeneic stem cell transplant for myelofibrosis- A retrospective single-center study Open

Dharma Choudhary, Divya Doval, Vipin Khandelwal, Rasika Setia, Anil Handoo · 2023

MF remains a challenging condition to treat, with a poor prognosis. Our study showed that reduced toxicity conditioning provided good DFS and OS. Thus, it should be offered to patients with high DIPSS scores. Sepsis was the predominant cau…

Hematopoietic stem cell transplantation in children –Early experience from a newly established center in India Open

Krishna Kant Singh, Divya Doval, Rajat Agarwal, Dharma Choudhary, Sandhya Chaudhary · 2023

Hematopoietic Stem Cell Transplant for Hematological Malignancies: Experience from a Tertiary Care Center in Northern India and Review of Indian Data Open

Sanjeev Kumar Sharma, Dharma Choudhary, Divya Doval, Vipin Khandelwal, Rasika Setia , et al. · 2021

Hematopoietic stem cell transplantation (HSCT) is the preferred treatment for high-risk and relapsed/refractory hematological malignancies. Moreover, with the improved supportive care and increasing acceptance of haploidentical transplanta…

Outcomes of COVID-19 in Hematopoietic Stem Cell Transplant Recipients: Multicenter Retrospective Analysis Open

Narendra Agrawal, Reema Singh, Sanjeev Sharma, Rahul Naithani, Rahul Bhargava , et al. · 2021

Effect of age, comorbidity and remission status on outcome of COVID-19 in patients with hematological malignancies Open

Pronamee Borah, Sumeet Mirgh, Sanjeev Sharma, Sachin Bansal, Ashish Dixit , et al. · 2020

Myeloablative Versus Reduced Intensity Conditioning Regimens for Allogeneic Hematopoietic Stem Cell Transplant for Acute Myeloid Leukemia and Myelodysplastic Syndrome: A Retrospective Analysis Open

Sanjeev Kumar Sharma, Dharma Choudhary, Divya Doval, Vipin Khandelwal, Amee B. Patel , et al. · 2020

Haploidentical Stem Cell Transplantation with Post-Transplant Cyclophosphamide in pediatric refractory Langerhans cell histiocytosis: a case Report Open

vipin khandelwal, Sanjeev Sharma, Dharma Choudhary, Divya Doval, SAROJ BALA , et al. · 2020

Children with multisystem - Langerhans cell histiocytosis (MS-LCH) that fails to respond to conventional chemotherapy have poor outcomes. Hematopoietic stem cell transplant (HSCT) represents a potential salvage approach. We report a first …

Hematopoietic Stem Cell Transplantation for Fanconi Anemia: A Single Center Experience from India Open

Divya Doval, Dharma Choudhary, Sanjeev Kumar Sharma, Vipin Khandelwal, Meet Kumar , et al. · 2020

Factor XIII Deficiency with a Novel Nonsense Mutation Open

Vipin Khandelwal, Sanjeev Sharma, Divya Doval, Meet Kumar, Dharma Choudhary , et al. · 2020

Second Transplant for Primary Graft Failure after Haematopoietic Stem Cell Transplant Open

Divya Doval, Dharma Choudhary, Sanjeev Sharma, Vipin Khandelwal, Meet Kumar , et al. · 2020

IntroductionPrimary graft failure after hematopoietic stem cell transplantation (HSCT) is a life threatening complication. The incidence is reported to be as high as 11%. It is very challenging as the patient is high risk having been pancy…

Outcome of Allogenic Hematopoietic Stem Cell Transplantation in Myelofibrosis: A Single-Center Retrospective Analysis Open

Dharma Choudhary, Divya Doval, Sanjeev Sharma, Vipin Khandelwal, Meet Kumar , et al. · 2020

ObjectiveTo study clinical outcome in patients with Myelofibrosis undergoing Allogenic hematopoietic stem cell transplantation.IntroductionAllogenic hematopoietic stem cell transplantation (HSCT) is currently the only curative treatment op…

Real-world outcomes of stem cell transplantation for severe aplastic anemia: A single-center experience in Northern India Open

D. K. Choudhury, Meet Kumar, Sanjeev Sharma, Vipin Khandelwal, Divya Doval , et al. · 2020

We conclude that MRDs remain the preferred donor source for allogeneic stem cell transplants in patients with aplastic anemia; however, HIDs can be considered as a life-saving treatment for patients with aplastic anemia.

T-cell replete Haplo-identical HSCT with Post transplant Cyclophosphamide for Hemoglobinopathies: A retrospective analysis from a single center Open

Dharma Choudhary, Divya Doval, Sanjeev Sharma, Vipin Khandelwal, Rasika Setia , et al. · 2020

We report herein haplo-identical hematopoietic stem cell transplantation (haplo-HSCT) by T-cell replete graft infusion, with post-transplant cyclophosphamide (PTCy) in patients with hemoglobinopathies. Patients received a conditioning regi…

Bone marrow transplant for recessive dystrophic epidermolysis bullosa Open

Vipin Khandelwal, Dharma Choudhary, Sanjeev Sharma, Divya Doval · 2019

Recessive dystrophic epidermolysis bullosa is an incurable, often fatal mucocutaneous blistering disease. A 2yr -old girl, presented with generalized bullous lesions since birth. She underwent matched sibling donor haemotopoietic stem cell…

Clofarabine‐induced bluish discolouration of teeth Open

Divya Doval, Sanjeev Sharma, Dharma Choudhary, Meet Kumar, Vipin Khandelwal · 2019

Clofarabine, a purine (deoxyadenosine) nucleoside analogue, is used in both paediatric and adult regimens to treat refractory or relapsed acute myeloid leukaemia and acute lymphoblastic leukaemia. Clofarabine has been used as monotherapy a…

Posterior Reversible Encephalopathy Syndrome in HSCT for Hemoglobinopathies Open

Divya Doval, Dharma Choudhary, Sanjeev Sharma, Vipin Khandelwal, Meet Kumar , et al. · 2019

IntroductionHSCT is the only curative treatment for thalassemia major (TM) & sickle cell disease (SCD) with excellent outcomes. However it is associated with several complications. Cyclosporine (C) and Tacrolimus (T) are frequently used fo…

Transfusion Associated Graft Versus Host Disease: A Case Report and Review of Literature Open

Divya Doval, Sanjeev Kumar Sharma, Meet Kumar, Vipin Khandelwal, Anil Handoo , et al. · 2019

Transfusion associated graft versus host disease (TA-GvHD) is a rare but usually fatal complication of transfusion of cellular blood products. It is seen usually in immunosuppressed individuals due to engraftment of viable T lymphocytes bu…

Desensitization with plasma exchange in a patient with human leukocyte antigen donor-specific antibodies before T-cell-replete haploidentical hematopoietic stem cell transplantation Open

Rasika Setia, Mitu Dogra, Divya Doval, Sanjeev Sharma, Dharma Choudhary , et al. · 2019

The presence of human leukocyte antigen (HLA) donor-specific antibodies (DSAs) increases the risk of graft failure in T-cell-replete haploidentical hematopoietic stem cell transplantation (haploidentical-HSCT). We report a case of a 20-yea…

Hematopoietic Stem Cell Transplant in Fanconi Anemia: A Single Centre Experience From India Open

Divya Doval, Dharma Choudhary, Vipin Khandelwal, Sanjeev Sharma, Bharti Sharma , et al. · 2018

Background: Fanconi anaemia (FA) is a autosomal recessive disorder characterized by multiple congenital malformations, progressive bone marrow failure and predisposition to malignancies. Allogeneic HSCT still remains the only treatment opt…

Improving the Accuracy of Hematopoietic STEM CELL DATA Open

Bharti Sharma, Divya Doval, Dharma Choudhary, Vipin Khandelwal, Sanjeev Sharma · 2018

Background: Almost 175 Hematopoietic stem cell transplants are done at our centre each year in a team comprising of 5 physicians. Maintaining the data manually of all these patients, year by year, accurately is a herculean task. Consolidat…

Allogenic Bone Marrow Transplant for Thalassemia Major—a Single Center Experience From India Open

Dharma Choudhary, Divya Doval, Sanjeev Sharma, Vipin Khandelwal, Rasika Setia , et al. · 2018

Background: Thalassemia major is an inherited haemoglobinopathy which results in ineffective erythropoiesis and patients require regular transfusion. Allogenic HSCT is the only curative treatment for patients with thalassemia major. Method…

Acute Graft-versus-host Disease Following Autologous Stem Cell Transplant for Multiple Myeloma Open

Sanjeev Sharma, Divya Doval, Dharma Choudhary, Vipin Khandelwal, Meet Kumar , et al. · 2018

INTRODUCTIONG raft-versus-host disease (GVHD) is common after allogeneic hematopoietic stem cell transplant (SCT) but has rarely been reported after autologous stem cell transplant (ASCT).Acute GVHD after ASCT can involve the gastrointesti…

Comparison of “Amicus and COBE Spectra” for autologous peripheral blood stem cell harvest: An Indian experience Open

Satyam Arora, Rasika Setia, Anil Handoo, Dharma Choudhary, SajeevKumar Sharma , et al. · 2017

Background: Adequate collection of peripheral stem cells from the patients depends on the disease condition, efficient mobilization and the equipment used for PBSC harvest. COBE Spectra has been the major platform for collecting these PBSC…

Rhizopus Laryngitis Post Allogenic Stem Cell Transplantation Open

Mayank Dhamija, Sanjeev Sharma, Dharma Choudhary, Vipin Khandelwal, Sweta Kothari , et al. · 2016

Invasive Fungal Infections (IFI) are an important complication and constitute significantly to mortality and morbidity, post Hematopoietic Stem Cell Transplant (HSCT). We report a very rare case of fungal laryngitis post HSCT in a 15-year-…

Allogenic hematopoeitic stem cell transplant for high risk acute pediatric leukemia: Single center experience Open

Vipin Khandelwal, Dharma Choudhary, Gaurav Kharya, Sanjeev Sharma, Divya Doval , et al. · 2016

Hematopoietic stem cell transplant for Hurler’s disease: A Case Report Open

Anamika Bakliwal, Gaurav Kharya, Vipin Khandelwal, Divya Doval, Sanjeev Sharma , et al. · 2016

Bone marrow transplant for Recessive Dystrophic Epidermolysis Bullosa: A case report Open

Vipin Khandelwal, Dharma Choudhary, Gaurav Kharya, Sanjeev Sharma, Divya Doval , et al. · 2016

Hematopoietic Stem Cell Transplant in Elderly Patients: Experience from a Tertiary Care Centre in Northern India Open

Sanjeev Sharma, Dharma Choudhary, Esha Kaul, Gaurav Kharya, Vipin Khandelwal , et al. · 2015

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