Explanipedia

Evaluation of symptom control in chronic obstructive pulmonary disease after reinforcement of proper inhaler technique Open

Tanya Jaiswal, Sparsh Gupta, Pooja Anand, Pranav Ish, Dhruv Sakkarwal , et al. · 2025

Chronic obstructive pulmonary disease (COPD) remains a leading cause of morbidity and mortality worldwide. Proper inhaler technique is a critical component of effective COPD management, yet it is often suboptimal in clinical practice. This…

A 36-base hairpin within lncRNA DRAIC, which is modulated by alternative splicing, interacts with the IKKα coiled-coil domain and inhibits NF-κB and tumor cell phenotypes Open

Xiaoxiao Hao, Yuechuan Chen, Divya Sahu, Roza Przanowska, Mujawar Aaiyas , et al. · 2025

A tumor-suppressive long-noncoding RNA (lncRNA) DRAIC (downregulated RNAin cancers) inhibits NF-κB activity and physically interacts with IKKα, a kinase component of the IKK complex, in several cancer types. Here we explore the precise mol…

A 36-base hairpin within lncRNA <i>DRAIC</i> , which is modulated by alternative splicing, interacts with the IKKα coiled-coil domain and inhibits NF-κB and tumor cell phenotypes Open

Xiaoxiao Hao, Yuechuan Chen, Divya Sahu, Roza Przanowska, Mujawar Aaiyas , et al. · 2024

A tumor-suppressive long noncoding RNA (lncRNA) DRAIC ( d own-regulated RN A in c ancers) inhibits NF-κB activity and physically interacts with IKKα, a kinase component of the IKK complex, in several cancer types. Here we explore the preci…

Development of a polygenic score predicting drug resistance and patient outcome in breast cancer Open

Divya Sahu, Jeffrey Shi, I. Rueda, Ajay Chatrath, Anindya Dutta · 2024

Correction: Evolutionarily conserved dual lysine motif determines the non-chaperone function of secreted Hsp90alpha in tumour progression Open

Mengchen Zou, Ashish C. Bhatia, Hangming Dong, Prajisha Jayaprakash, Juchen Guo , et al. · 2024

Following the publication of this article, it was noted that the positive control of MDA-MB-231 cells in Figure 2F (panel v) and a non-specific mutant control of recombinant Hsp90β in Figure 4E (panel h) were mistakenly duplicated with the…

Assessment of Embrace-WetBond and Fissurit F Pit and Fissure Sealants’ Marginal Sealing Abilities Open

Keyur Joshi, Sudheer Kumar Avula, Divya Sahu, Gaurav Mishra, Roli Agrawal , et al. · 2023

A BSTRACT Objectives: The goal of the current research was to assess marginal sealing abilities of 2 commercial pit and fissure sealants. Materials and Methods: A total of 30 premolar teeth were equally classified into 2 groups: Group A-ap…

Transcriptomic Profiling Reveals an Enhancer RNA Signature for Recurrence Prediction in Colorectal Cancer Open

Divya Sahu, Chen-Ching Lin, Ajay Goel · 2023

Background: Colorectal cancer (CRC) is one of the most fatal malignancies worldwide, and this is in part due to high rates of tumor recurrence in these patients. Currently, TNM staging remains the gold standard for predicting prognosis and…

Prognostic and predictive biomarkers for response to neoadjuvant chemoradiation in esophageal adenocarcinoma Open

Hirsch Matani, Divya Sahu, Michael Paskewicz, Anastasia Gorbunova, Ashten N. Omstead , et al. · 2022

Transcriptomic profiling reveals an enhancer RNA signature for recurrence prediction in colorectal cancer Open

Divya Sahu, Chen-Ching Lin, Ajay Goel · 2022

Background Colorectal cancer (CRC) is one of the most fatal malignancies worldwide, and this is in part due to high rates of tumor recurrence in these patients. Currently, TNM staging remains the gold standard for predicting prognosis and …

Integrated bioinformatic pipeline using whole-exome and RNAseq data to identify germline variants correlated with cancer Open

Divya Sahu, Ajay Chatrath, Aakrosh Ratan, Anindya Dutta · 2022

Novel Predictive and Prognostic Gene Signatures for Chemoradiotherapy in Locally Advanced Esophageal Adenocarcinoma Open

Hirsch Matani, Rodney E. Wegner, Michael Paskewicz, Divya Sahu, Ashten N. Omstead , et al. · 2021

Bladder Cancer Invasion Is Mediated by Mammalian Target of Rapamycin Complex 2–Driven Regulation of Nitric Oxide and Invadopodia Formation Open

Divya Sahu, Jianya Huan, Huawei Wang, Debashis Sahoo, Darren E. Casteel , et al. · 2021

Characterization of the Survival Influential Genes in Carcinogenesis Open

Divya Sahu, Yu-Lin Chang, Yin-Chen Lin, Chen-Ching Lin · 2021

The genes influencing cancer patient mortality have been studied by survival analysis for many years. However, most studies utilized them only to support their findings associated with patient prognosis: their roles in carcinogenesis have …

In Vitro Antidiabetic Effect of Neohesperidin Open

Durgeshnandani Sinha, Trilochan Satapathy, Parag Jain, Jhakeshwar Prasad Chandel, Divya Sahu , et al. · 2019

Objective: The present study was performed to determine in vitro antidiabetic effect of neohesperidin. To evaluate inhibitory effect of neohesperidin on α-amylase and α-glucosidase diabetes causing enzyme. Methods and Materials: Invitro c…

Identification and characterization of the lncRNA signature associated with overall survival in patients with neuroblastoma Open

Srinivasulu Yerukala Sathipati, Divya Sahu, Hsuan‐Cheng Huang, Yen-Ching Lin, Shinn‐Ying Ho · 2019

High-risk, Expression-Based Prognostic Long Noncoding RNA Signature in Neuroblastoma Open

Divya Sahu, Shinn‐Ying Ho, Hsueh‐Fen Juan, Hsuan‐Cheng Huang · 2018

Background Current clinical risk factors stratify patients with neuroblastoma (NB) for appropriate treatments, yet patients with similar clinical behaviors evoke variable responses. MYCN amplification is one of the established drivers of N…

Metabolomics analysis reveals distinct profiles of nonmuscle‐invasive and muscle‐invasive bladder cancer Open

Divya Sahu, Yair Lotan, Bryan M. Wittmann, Bruce Neri, Donna E. Hansel · 2017

Urothelial carcinoma is the most common form of bladder cancer, but pathway changes that occur with stage‐wise progression have not been well defined. We used a metabolomics approach to identify potential metabolic pathways uniquely altere…

Are tooth prints a hard tissue equivalence of finger print in mass disaster: A rationalized review Open

Shaik Kamal Sha, BoinapelliVengal Rao, Mamidanna S. Rao, K V Halini Kumari, Sudarshan Kumar Chinna , et al. · 2017

Personal identification methods may not be efficient when bodies are decomposed, burned, in cases of mass disasters when soft tissue cannot provide reliable information or has been lost. Various methods currently employed in forensic odont…

Argininosuccinate Synthetase 1 Loss in Invasive Bladder Cancer Regulates Survival through General Control Nonderepressible 2 Kinase–Mediated Eukaryotic Initiation Factor 2α Activity and Is Targetable by Pegylated Arginine Deiminase Open

Divya Sahu, Sounak Gupta, Andrew M. Hau, Kazufumi Nakashima, Mariah Z. Leivo , et al. · 2016

Evolutionarily conserved dual lysine motif determines the non-chaperone function of secreted Hsp90alpha in tumour progression Open

Mengchen Zou, Ashish C. Bhatia, Hangming Dong, Priyamvada Jayaprakash, Juchen Guo , et al. · 2016

Both intracellular and extracellular heat shock protein-90 (Hsp90) family proteins (α and β) have been shown to support tumour progression. The tumour-supporting activity of the intracellular Hsp90 is attributed to their N-terminal ATPase-…

An Osteopontin/CD44 Axis in RhoGDI2-Mediated Metastasis Suppression Open

Mansoor Ahmed, Joseph L. Sottnik, Garrett M. Dancik, Divya Sahu, Donna E. Hansel , et al. · 2016

Co-expression analysis identifies long noncoding RNA <i>SNHG1</i> as a novel predictor for event-free survival in neuroblastoma Open

Divya Sahu, Chia‐Lang Hsu, Chen-Ching Lin, Tz-Wen Yang, Wen‐Ming Hsu , et al. · 2016

Despite of the discovery of protein therapeutic targets and advancement in multimodal therapy, the survival chance of high-risk neuroblastoma (NB) patients is still less than 50%. MYCN amplification is a potent driver of NB, which exerts i…

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