Explanipedia

Developing Complex Odontome–an Enigmatic Entity: A Case Report Open

Buddha Harika Varshita, Divya Uppala, Sreekanth Kotina, YS Raviteja, Hyandavi Balla , et al. · 2025

A benign mixed odontogenic lesion, with features of ameloblastic fibro odontoma previously allocated in the WHO 2005 classification, and presently removed in the subsequent WHO 2017 and 2022 classifications, shows certain changes that resu…

Identification of Micrometastasis Using Papanicolaou Stain in Nodal Tissues of Oral Squamous Cell Carcinoma - A Retrospective Study Open

Hyandavi Balla, Divya Uppala, Sreekanth Kotina, Sahithi Pamidimukkala, Tejaswi Kodem · 2025

Metastasis is innate tendency of malignancy. Lymphatic spread plays a crucial role in the progression of Head and Neck Squamous Cell Carcinoma and significantly influences tumor staging. The presence of regional lymph node involvement redu…

Clinicopathologic Study on Odontogenic Tumors-A 10-Year Single Institute Experience Open

U.D.N. Sreevalli, Divya Uppala, Buddha Harika Varshita · 2025

Introduction: Odontogenic tumors are the expansile group of jaw neoplasm that originates from the tooth-forming tissues. WHO, revised classification several times due to their discrete histological and biological behavior. They were broadl…

Desmoglein 1 and 3 as potential markers of occult lymph node metastasis in oral cancer Open

Yellarthi Pavan Kumar, Arvind Muthukrishnan, Venkata Madhavi Bellala, Bairavi Shankar, Sandhya Pavankumar , et al. · 2025

Objectives: The majority of oral cancers are oral squamous cell carcinomas (OSCC). The successful management of OSCC depends on early detection, timely intervention, and prevention of distant metastasis. Metastasis is an important aspect o…

A Systematic Review on the Role of Desmoglein 1 and Desmoglein 3 in Etiopathogenesis and Metastasis of Oral Cancer Open

Pavan Kumar Yellarthi, Arvind Muthukrishnan, Gandikota Raghurama Rao, Sandhya Pavankumar, Divya Uppala · 2025

Background: Desmosomal proteins have a fundamental role in cellular adhesion as they not only maintain cellular homeostasis but also regulate cellular activities like proliferation, differentiation, and migration. Desmosomal protein expres…

COMPARATIVE ASSESSMENT OF T-PRF ALONE AND T-PRF INJECTED WITH ANTIBIOTICGELS, HERBAL PRODUCT SEPARATELY: A HISTOLOGICAL STUDY Open

Shiva Shankar Gummaluri, Gurumoorthy Kaarthikeyan, Trinath Kishore Damera, Divya Uppala, Anusha Boddeda , et al. · 2025

Background: Antibiotics and herbal product incorporation into T-PRF are scant. Hence present study aimed to assess the fibrin network pattern, cellularity, cell distribution for T-PRF injected with metronidazole gel (MTZ), amoxicillin+ cla…

Reactive Lesions of the Oral Mucosa: A Retrospective Analysis of 69 Cases Open

Vaddadi Sindhuja, Vipparthi Sharon Raj, Divya Uppala · 2025

Introduction: Reactive lesions encompass a category of fibroepithelial lesions that are frequently observed in the oral mucosa. Due to the oral cavity’s significant exposure to trauma or frictional forces, the incidence of these reactive l…

Prognostic Significance and Therapeutic Implications of CD34, an Angiogenic Marker, in Oral Squamous Cell Carcinoma: A Narrative Review Open

Niva Mahapatra, S. Nithya, Divya Uppala, Soundarya Srinivasan, Daffney Mano Doss · 2024

Head and neck cancer is the 7th most common malignancy worldwide. Few decades earlier, there has been an enormous rise in genetic events as the source in the development of Oral Squamous Cell Carcinoma (OSCC) and metastasis to various orga…

INTRAOSSEOUS EPIDERMOID CYST OF JAW – A case report Open

Divya Uppala, U Sivakalyan, UDN Sreevalli, Buddha Harika Varshita, Mounica Tirumalareddy · 2024

Epidermoid cysts are benign, rare which can occur all throughout the body of an individual. Their occurrence in the oral cavity is rare and is difficult to distinguish from other intraoral cysts. Method A 27-year-old female patient present…

An anthropometric assessment method for facial profile determination in forensics Open

Uppuganti Devi Naga Sreevalli, Harika Varshita Buddha, Divya Uppala · 2024

Objectives: It is extremely difficult for forensic experts to identify the individuals, especially during mass disasters and natural calamities such as earthquakes. In most cases, the facial profile is completely destroyed and the dentitio…

Evaluation of Desmoglein 1 and Desmoglein 3 Autoantibodies in Oral Cancer: A Pilot Study Open

Arvind Muthukrishnan, PavanKumar Yellarthi, RaghuramaRao Gandikota, Y. Sandhya Pavankumar, Divya Uppala · 2023

Background: Carcinogenesis is a complex multistep process involving alterations at the cellular level. Alteration in cell-to-cell adhesion of oral epithelium plays an important role in carcinogenesis and metastasis. The alterations in the …

Decalcification- The Path to Hard Tissue Visualization Open

Tompala Vinod Kumar, Leela Lavanya Gadam, Ogirala Smyrna, Divya Uppala · 2022

The decalcification procedure is a process of completely removing the calcium salt from the bone and teeth which are mineralized tissues, and also some other calcified tissues.Through this procedure mineralized component is removed, and th…

Protein Isolation and Beyond Open

Divya Uppala, K Snetha · 2022

Brown tumor of hyperparathyroidism with multiple lesions Open

Sumit Majumdar, Divya Uppala, Sreekanth Kotina, Bandi Alekhya · 2022

Brown tumors are rare focal giant-cell lesions that arise as a direct result of the effect of parathyroid hormone (PTH) on bone tissue in some patients with hyperparathyroidism. Browns tumor is a syndrome associated with an increase in PTH…

Odontogenic carcinosarcoma – A rare case report with review of literature Open

Sumit Majumdar, Divya Uppala, Kotina Sreekanth, Bandi Alekhya · 2022

Odontogenic carcinosarcoma (OCS) is a rare malignant odontogenic tumor (OT) with only a few cases reported in the literature. Its synonyms are ameloblastic carcinosarcoma, malignant mixed OT. It is characterized by a true mixed tumor showi…

Cholesteatoma of maxillary sinus simulating neoplasia: A rare case report Open

Sushma Vakalapudi, Sumit Majumdar, Divya Uppala · 2021

The term cholesteatoma refers to "chole": cholesterol, "steat": fat and "oma,": "tumor". This tumor has been reported to be the most common in the middle ear. The occurrence of such a tumor in the maxillary sinus is deemed to be very rare …

Round Cell Tumors – A Brief Overview! Open

Addanki Naga Valli Anusha, Divya Uppala, B. Alekhya, Kalyan Kanth K · 2020

A group of neoplasms that share the characteristic light microscopic appearance of being composed of relatively small, round to round-spindled, monotonous, seemingly undifferentiated cells.It comprises all significant categories of neoplas…

Evaluation of immunomorphological patterns of cervical lymph nodes in oral squamous cell carcinoma Open

Hyandavi Balla, Divya Uppala, Sumit Majumdar, Sreekanth Kotina, Sravya Kodati , et al. · 2020

Background: The Immunomorphological patterns of Lymph Nodes indirectly assess the host immune response facing a malignant tumor. These patterns also help us predict the susceptibility of the patient to Lymph Node Metastasis. Aims and Objec…

Expression of heat shock protein 70 in oral epithelial dysplasia and oral squamous cell carcinoma: An immunohistochemical study Open

KP Priyanka, Sumit Majumdar, Sreekanth Kotina, Divya Uppala, Hyandavi Balla · 2019

This study concludes the critical role of HSP70 as an oncogene in the development of oral cancer. HSP70 inhibition is, therefore a promising therapeutic approach for cancer treatment.

Human papillomavirus detection in oropharyngeal squamous cell carcinoma using p16 immunohistochemistry Open

Divya Uppala, A. Sabu, NV Ratna Mouli, N Tejaswini, V Rohit , et al. · 2019

Our results suggest that IHC-based detection of p16 provides a suboptimal prognostic information if not combined with detection of HPV DNA. Although p16 expression and HPV DNA infection are correlated with HPV-associated OPSCCs, neither of…

A systematic review of saliva on its diagnostic utility Open

Neeharika Mortha, Divya Uppala, NanditaR Kothia, Sumit Majumdar, Sreekanth Kotina , et al. · 2018

Introduction: A paradigm shift in recent years has led to the consideration of the oral cavity (and, thus, oral disease) not in isolation but as a component integrated with systemic physiology, important in maintaining systemic health and …

The “TROJAN HORSE” of a dental visit – synovial sarcoma Open

Neeharika Mortha, Sumit Majumdar, Divya Uppala, Sreekanth Kotina · 2018

The term "synovial sarcoma (SS)" is a histological error, a misnomer as it neither arises from nor differentiates toward synovium. Head and neck region is the most commonly affected region after extremities, representing 5% of all cases. T…

Quantitative assessment of silver-stained nucleolar organizer region in odontogenic cysts to correlate the growth and malignant potentiality Open

Divya Uppala, SailendraNath Biswas, RR Paul, JayGopal Ray, Sumit Majumdar · 2017

Therefore, AgNor could be used as an efficient tool for comparative evaluation of microscopic features such as epithelial thickness, surface keratinization and mural proliferation in dentigerous cyst to that of the AgNOR count.

Ghost Cell Odontogenic Carcinoma Arising Denovo with Distant Metastasis: A Case Report and Review of Literature Open

Madhurya Namana, Sumit Majumdar, Divya Uppala, Aditya Avv, Ayyagari Kameswara Rao · 2017

Ghost Cell Odontogenic Carcinoma (GCOC) is a rare malignant odontogenic tumour of epithelial origin accounting about 0.37% to 2.1% of all odontogenic tumours. They are characterized by the presence of ameloblastic islands along with ghost …

Evaluation of genetic polymorphisms in glutathione S-Transferase theta1, glutathione S-Transferase mu1, and glutathione S-Transferase mu3 in oral leukoplakia and oral squamous cell carcinoma with deleterious habits using polymerase chain reaction Open

AyyagariKameswara Rao, Peela Parameswar, Sumit Majumdar, Divya Uppala, Sreekanth Kotina , et al. · 2017

Hence to conclude, because of small sample size in the present study, statistically insignificant results were found and this study failed to observe the relationship between GSTM3 and GSTT1 polymorphism and risk of developing OSCC and pos…

Malignant Peripheral Nerve Sheath Tumor -A Rare Malignancy in Mandible Open

Sumit Majumdar, Sreekanth Kotina, N. Mahesh, Divya Uppala, Singam Praveen Kumar · 2016

Malignant Peripheral Nerve Sheath Tumor (MPNST) is biologically an aggressive tumor that is usually found in the extremities, trunk and infrequently found in the head and neck area particularly in the jaws, arising from the cells allied wi…

Ameloblastic Carcinoma: A Report of Three Cases Open

Sravya Kodati, Sumit Majumdar, Divya Uppala, Madhurya Namana · 2016

Malignant odontogenic tumours are rare and represent approximately 1% of all oral malignancies. Ameloblastic carcinoma is a rare odontogenic tumour, which is aggressive in nature with extensive local bone destruction that has retained the …

Mesenchymal chondrosarcoma of mandible Open

Rajyalakshmi Boddepalli, Sumit Majumdar, Divya Uppala, A Kameswara Rao · 2016

Mesenchymal chondrosarcomas (MC) are rare and aggressive forms of chondrosarcoma. They are distinct tumors arising in unicentric or multicentric locations from both skeletal and extraskeletal tissues. The most affected region is the facial…

Are salivary amylase and pH – Prognostic indicators of cancers? Open

A. Ramya, Divya Uppala, Sumit Majumdar, Surekha Challa, K.G.K. Deepak · 2015

Langerhans cell histiocytosis (LCH) of the mandible in an adult: a rare case Open

Naga Himabindu Vennamaneni, Sumit Majumdar, Nalam Sai Gautam, Divya Uppala · 2015

Langerhans cell histiocytosis (LCH) is a clonal proliferation of Langerhans cells (immature dendritic cells) occurring as an isolated lesion or as part of a systemic (multifocal) proliferation. LCH is classified under dendritic cell-relate…

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