Diyoly Ayona
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View article: Dynamics of antibody engagement of red blood cells in vivo and in vitro
Dynamics of antibody engagement of red blood cells in vivo and in vitro Open
Exposure to allogenic red blood cells (RBCs), either through pregnancy or transfusion, can result in alloimmunization, which can lead to severe hemolytic transfusion reactions and pregnancy complications. Passively administered antibodies …
View article: Galectin-4 Antimicrobial Activity Primarily Occurs Through its C-Terminal Domain
Galectin-4 Antimicrobial Activity Primarily Occurs Through its C-Terminal Domain Open
View article: Antibody-mediated antigen loss switches augmented immunity to antibody-mediated immunosuppression
Antibody-mediated antigen loss switches augmented immunity to antibody-mediated immunosuppression Open
Antibodies against fetal red blood cell (RBC) antigens can cause hemolytic disease of the fetus and newborn (HDFN). Reductions in HDFN due to anti-RhD antibodies have been achieved through use of Rh immune globulin (RhIg), a polyclonal ant…
View article: Prior Immunization to an Intracellular Antigen Enhances Subsequent Red Blood Cell Alloimmunization in Mice
Prior Immunization to an Intracellular Antigen Enhances Subsequent Red Blood Cell Alloimmunization in Mice Open
Antibodies to red blood cell (RBC) alloantigens can increase morbidity and mortality in transfusion recipients. However, alloimmunization rates can vary dramatically, with some patients never generating alloantibodies following transfusion…
View article: Galectin-9 recognizes and exhibits antimicrobial activity toward microbes expressing blood group–like antigens
Galectin-9 recognizes and exhibits antimicrobial activity toward microbes expressing blood group–like antigens Open
While adaptive immunity recognizes a nearly infinite range of antigenic determinants, immune tolerance renders adaptive immunity vulnerable to microbes decorated in self-like antigens. Recent studies suggest that sugar-binding proteins gal…
View article: Human galectin-1 and galectin-3 promote <i>Tropheryma whipplei</i> infection
Human galectin-1 and galectin-3 promote <i>Tropheryma whipplei</i> infection Open
Tropheryma whipplei, is an actinobacterium that causes different infections in humans, including Whipple's disease. The bacterium infects and replicates in macrophages, leading to a Th2-biased immune response. Previous studies have …
View article: Utilization of Galectins by Pathogens for Infection
Utilization of Galectins by Pathogens for Infection Open
Galectins are glycan-binding proteins which are expressed by many different cell types and secreted extracellularly. These molecules are well-known regulators of immune responses and involved in a broad range of cellular and pathophysiolog…