Explanipedia

07 Simultaneous Positron Emission Tomography and Magnetic Resonance Imaging of Receptors Using a Novel Combined Pre-Clinical Micropet/Mr System Open

Joseph Bird, RC Hawkes, Roido Manavaki, Stephen J. Sawiak, DJ Williamson , et al. · 2012

Vascular and cardiac diseases are complex pathologies and preclinical models are required to fully investigate the multifactorial interactions. In vivo imaging techniques are important research tools in quantifying pathogenic mechanisms an…

<i>N</i>-Heteroaryl-2-phenyl-3-(benzyloxy)piperidines: A Novel Class of Potent Orally Active Human NK<sub>1</sub> Antagonists Open

T. Ladduwahetty, R. Baker, Margaret A. Cascieri, Mark S. Chambers, K. Haworth , et al. · 1996

The preparation of a series of N-heteroarylpiperidine ether-based human NK1 antagonists is described. Two of the compounds 3-[-(2S,3S)-3-(((3,5-bis(trifluoromethyl)phenyl)methyl)oxy)- 2-phenylpiperidino}methyl]-1,2,4-triazole (11) and 5-[¿…

Effects of purified bacterially synthesized murine multi-CSF (IL-3) on hematopoiesis in normal adult mice Open

D Metcalf, C. Glenn Begley, GR Johnson, Nicos A. Nicola, Angel F. López , et al. · 1986

Normal adult C57BL, BALB/c, and C3H/HeJ mice were injected intraperitoneally three times daily for up to 6 days with 102,000 U (200 ng) per injection of purified, bacterially synthesized, Multipotential colony-stimulating factor (CSF) (Int…

Effects of purified bacterially synthesized murine multi-CSF (IL-3) on hematopoiesis in normal adult mice Open

D Metcalf, C. Glenn Begley, GR Johnson, Nicos A. Nicola, Angel F. López , et al. · 1986

Normal adult C57BL, BALB/c, and C3H/HeJ mice were injected intraperitoneally three times daily for up to 6 days with 102,000 U (200 ng) per injection of purified, bacterially synthesized, Multipotential colony-stimulating factor (CSF) (Int…

Biologic properties in vitro of a recombinant human granulocyte- macrophage colony-stimulating factor Open

D Metcalf, C. Glenn Begley, GR Johnson, Nicos A. Nicola, MA Vadas , et al. · 1986

Recombinant human granulocyte-macrophage colony-stimulating factor (rH GM-CSF) was purified to homogeneity from medium conditioned by COS cells transfected with a cloned human GM-CSF cDNA and shown to be an effective proliferative stimulus…

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