Django White
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View article: 1191 Development of a Clinically-Validated Questionnaire and Scoring Algorithm Designed to Identify Common Sleep Problems Among Adults
1191 Development of a Clinically-Validated Questionnaire and Scoring Algorithm Designed to Identify Common Sleep Problems Among Adults Open
Introduction Although sleep is critical to maintaining health and quality of life, inadequate sleep duration and/or quality is common. It can be difficult to distinguish sleep problems that may be addressed through adjustments to lifestyle…
View article: Cohort profile: the Brain and Mind Centre <i>Optymise</i> cohort: tracking multidimensional outcomes in young people presenting for mental healthcare
Cohort profile: the Brain and Mind Centre <i>Optymise</i> cohort: tracking multidimensional outcomes in young people presenting for mental healthcare Open
Purpose The Brain and Mind Centre (BMC) Optymise cohort assesses multiple clinical and functional domains longitudinally in young people presenting for mental health care and treatment. Longitudinal tracking of this cohort will allow inves…
View article: Transdiagnostic neurocognitive subgroups and functional course in young people with emerging mental disorders: a cohort study
Transdiagnostic neurocognitive subgroups and functional course in young people with emerging mental disorders: a cohort study Open
Background Neurocognitive impairments robustly predict functional outcome. However, heterogeneity in neurocognition is common within diagnostic groups, and data-driven analyses reveal homogeneous neurocognitive subgroups cutting across dia…
View article: Clinical Stage Transitions in Persons Aged 12 to 25 Years Presenting to Early Intervention Mental Health Services With Anxiety, Mood, and Psychotic Disorders
Clinical Stage Transitions in Persons Aged 12 to 25 Years Presenting to Early Intervention Mental Health Services With Anxiety, Mood, and Psychotic Disorders Open
Differential rates of progression from earlier to later stages of anxiety, mood, psychotic, or comorbid disorders were observed in young persons who presented for care at various stages. Understanding the rate and factors associated with t…
View article: What is the prevalence, and what are the clinical correlates, of insulin resistance in young people presenting for mental health care? A cross-sectional study
What is the prevalence, and what are the clinical correlates, of insulin resistance in young people presenting for mental health care? A cross-sectional study Open
Objectives To report the distribution and predictors of insulin resistance (IR) in young people presenting to primary care-based mental health services. Design Cross-sectional. Setting Headspace-linked clinics operated by the Brain and Min…
View article: Exploring associations between early substance use and longitudinal socio-occupational functioning in young people engaged in a mental health service
Exploring associations between early substance use and longitudinal socio-occupational functioning in young people engaged in a mental health service Open
Neuropsychiatric disorders (including substance misuse) are associated with the greatest burden of functional disability in young people, and contributory factors remain poorly understood. Early-onset substance use is one candidate risk fa…
View article: Parallel Changes in Mood and Melatonin Rhythm Following an Adjunctive Multimodal Chronobiological Intervention With Agomelatine in People With Depression: A Proof of Concept Open Label Study
Parallel Changes in Mood and Melatonin Rhythm Following an Adjunctive Multimodal Chronobiological Intervention With Agomelatine in People With Depression: A Proof of Concept Open Label Study Open
Background: Agomelatine is a melatonin agonist and 5HT antagonist developed for the treatment of major depressive disorder which also has some effects on the circadian system. Since circadian dysfunctions are thought to play a role in the …
View article: Autism, Early Psychosis, and Social Anxiety Disorder: a transdiagnostic examination of executive function cognitive circuitry and contribution to disability
Autism, Early Psychosis, and Social Anxiety Disorder: a transdiagnostic examination of executive function cognitive circuitry and contribution to disability Open
The disability burden in clinical cohorts with social impairment is significant, leading to poor functional outcomes. Some of this impairment has been linked to executive dysfunction. In this study, a transdiagnostic approach was taken to …
View article: A pilot study of a brief intervention program (RECHARGE) to reduce sleep-wake and circadian rhythm disturbances in youth being treated for depression
A pilot study of a brief intervention program (RECHARGE) to reduce sleep-wake and circadian rhythm disturbances in youth being treated for depression Open
Aim: Sleep-wake and circadian rhythm disturbances are linked to the emergence and persistence of depression in youth. However, few youth-specific interventions have been developed to address this in clinical settings. We aimed to test the …
View article: Lower In vivo Myo-Inositol in the Anterior Cingulate Cortex Correlates with Delayed Melatonin Rhythms in Young Persons with Depression
Lower In vivo Myo-Inositol in the Anterior Cingulate Cortex Correlates with Delayed Melatonin Rhythms in Young Persons with Depression Open
Myo-inositol, a second messenger glucose isomer and glial marker, is potentiated by melatonin. In addition to common abnormalities in melatonin regulation, depressive disorders have been associated with reduced myo-inositol in frontal stru…
View article: Quantifying the effect of body mass index, age, and depression severity on 24-h activity patterns in persons with a lifetime history of affective disorders
Quantifying the effect of body mass index, age, and depression severity on 24-h activity patterns in persons with a lifetime history of affective disorders Open
These findings suggest that older age and higher BMI are linked to lower daytime activity levels. Higher BMI and worse symptom severity were also associated with nocturnal activity patterns suggestive of sleep disturbances. The influence o…
View article: The Relationship between Sleep-Wake Cycle and Cognitive Functioning in Young People with Affective Disorders
The Relationship between Sleep-Wake Cycle and Cognitive Functioning in Young People with Affective Disorders Open
Although early-stage affective disorders are associated with both cognitive dysfunction and sleep-wake disruptions, relationships between these factors have not been specifically examined in young adults. Sleep and circadian rhythm disturb…
View article: Body mass, cardiovascular risk and metabolic characteristics of young persons presenting for mental healthcare in Sydney, Australia
Body mass, cardiovascular risk and metabolic characteristics of young persons presenting for mental healthcare in Sydney, Australia Open
Objectives To determine the body mass, cardiovascular and metabolic characteristics of young people presenting for mental healthcare. Design Cross-sectional assessments of body mass, cardiovascular and metabolic risk factors. Setting Two p…
View article: Ambulatory sleep-wake patterns and variability in young people with emerging mental disorders
Ambulatory sleep-wake patterns and variability in young people with emerging mental disorders Open
Background: The nature of sleep-wake abnormalities in individuals with mental disorders remains unclear. The present study aimed to examine the differences in objective ambulatory measures of the sleep-wake and activity cycles across young…