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View article: Improvement of antioxidant capability by dietary N-acetyl cysteine supplementation alleviates bone loss induced by chronic heat stress in finisher broilers
Improvement of antioxidant capability by dietary N-acetyl cysteine supplementation alleviates bone loss induced by chronic heat stress in finisher broilers Open
Background Heat stress (HS) incidence is associated with the accumulation of reactive substances, which might be associated with bone loss. N -Acetylcysteine (NAC) exhibits strong antioxidants due to its sulfhydryl group and being as the p…
View article: GDF15 mediates inflammation-associated bone loss through a brain-bone axis
GDF15 mediates inflammation-associated bone loss through a brain-bone axis Open
Metabolic mediators play an important role in regulating inflammation(1). Rheumatoid arthritis and spondyloarthritis are common inflammatory diseases of the joint, aggravated in context of obesity(2). These patients experience systemic bon…
View article: GDF15 mediates inflammation-associated bone loss through a brain-bone axis
GDF15 mediates inflammation-associated bone loss through a brain-bone axis Open
SUMMARY Metabolic mediators play an important role in regulating chronic inflammation in the body. Here we report an unexpected role for GDF15 (Growth Differentiation Factor 15), a central mediator of food intake, in inflammation-associate…
View article: RORγt inhibition ameliorates IL-23 driven experimental psoriatic arthritis by predominantly modulating γδ-T cells
RORγt inhibition ameliorates IL-23 driven experimental psoriatic arthritis by predominantly modulating γδ-T cells Open
Objective Divergent therapeutic outcomes on different disease domains have been noted with IL-23 and IL-17A-blockade in PsA. Therefore, elucidating the role of RORγt, the master regulator of type 17 immune responses, is of potential therap…
View article: <scp>A20</scp> controls <scp>RANK</scp> ‐dependent osteoclast formation and bone physiology
<span>A20</span> controls <span>RANK</span> ‐dependent osteoclast formation and bone physiology Open
View article: 25-hydroxycholecalciferol reverses heat induced alterations in bone quality in finisher broilers associated with effects on intestinal integrity and inflammation
25-hydroxycholecalciferol reverses heat induced alterations in bone quality in finisher broilers associated with effects on intestinal integrity and inflammation Open
View article: <scp>ER</scp> stress in antigen‐presenting cells promotes <scp>NKT</scp> cell activation through endogenous neutral lipids
<span>ER</span> stress in antigen‐presenting cells promotes <span>NKT</span> cell activation through endogenous neutral lipids Open
View article: Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche
Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche Open
View article: Running promotes chronicity of arthritis by local modulation of complement activators and impairing T regulatory feedback loops
Running promotes chronicity of arthritis by local modulation of complement activators and impairing T regulatory feedback loops Open
View article: Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha
Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha Open
View article: Mechanical strain determines the site-specific localization of inflammation and tissue damage in arthritis
Mechanical strain determines the site-specific localization of inflammation and tissue damage in arthritis Open
Many pro-inflammatory pathways leading to arthritis have global effects on the immune system rather than only acting locally in joints. The reason behind the regional and patchy distribution of arthritis represents a longstanding paradox. …
View article: Checkpoint inhibition in the treatment of multiple myeloma: A way to boost innate-like T cell anti-tumor function?
Checkpoint inhibition in the treatment of multiple myeloma: A way to boost innate-like T cell anti-tumor function? Open
View article: O027 Mechanical strain determines the site-specific direction of inflammation and tissue damage in arthritis
O027 Mechanical strain determines the site-specific direction of inflammation and tissue damage in arthritis Open
View article: FRI0029 The oxygen sensor phd1 is an indispensable regulator of arthritis development
FRI0029 The oxygen sensor phd1 is an indispensable regulator of arthritis development Open
View article: Application of µCT in arthritis and osteoporosis research
Application of µCT in arthritis and osteoporosis research Open
Arthritis and osteoporosis are chronic disorders in which bone is dramatically affected. Bone erosion in the joints is a disabling hallmark of Rheumatoid Arthritis (RA) and Spondyloarthritides (SpA), two prototypic forms of chronic arthrit…