Derek Connolly
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View article: Optimizing lipid-lowering therapy for acute coronary syndrome using a decision support system: insights from a cluster randomized trial
Optimizing lipid-lowering therapy for acute coronary syndrome using a decision support system: insights from a cluster randomized trial Open
Aims Lipid-lowering therapy (LLT) after acute coronary syndrome (ACS) typically follows stepwise intensification, delaying use of combination therapies and low-density lipoprotein cholesterol (LDL-C) goal attainment. We assessed whether ac…
View article: The long‐term outcome and changes in tricuspid regurgitation pressure gradient in dogs diagnosed with pulmonary hypertension and <i>Angiostrongylus vasorum</i> infestation
The long‐term outcome and changes in tricuspid regurgitation pressure gradient in dogs diagnosed with pulmonary hypertension and <i>Angiostrongylus vasorum</i> infestation Open
Objectives Angiostrongylus vasorum (AV) is a metastrongylid parasite that has been associated with pulmonary hypertension (PH) in dogs. The objectives of the study were to describe the clinical presentation of dogs with AV and PH, document…
View article: Advancing Cardiovascular, Kidney, and Metabolic Medicine: A Narrative Review of Insights and Innovations for the Future
Advancing Cardiovascular, Kidney, and Metabolic Medicine: A Narrative Review of Insights and Innovations for the Future Open
Cardiovascular, kidney and metabolic (CKM) conditions are interrelated, significantly contributing to morbidity, mortality and healthcare burden. Despite therapeutic advances, traditional disease-specific approaches often fail to address t…
View article: Real-World Comparisons Between Glucagon-Like Peptide-1 Receptor Agonists and Other Glucose-Lowering Agents in Type 2 Diabetes: Retrospective Analyses of Cardiovascular and Economic Outcomes in England
Real-World Comparisons Between Glucagon-Like Peptide-1 Receptor Agonists and Other Glucose-Lowering Agents in Type 2 Diabetes: Retrospective Analyses of Cardiovascular and Economic Outcomes in England Open
In a real-world setting, GLP-1RAs may be associated with a lower risk of MACE and reduced HCRU and costs than DPP4 inhibitors or basal insulin in individuals with T2D, particularly among those at very high cardiovascular risk.
View article: Role of community pharmacy in the prevention of cardiovascular disease in minority ethnic groups in the UK including barriers and facilitators: protocol for a mixed methods systematic review
Role of community pharmacy in the prevention of cardiovascular disease in minority ethnic groups in the UK including barriers and facilitators: protocol for a mixed methods systematic review Open
Introduction Cardiovascular disease (CVD) remains a major public health issue in the United Kingdom (UK) and disproportionately affects minority ethnic groups who face higher rates of CVD, necessitating targeted interventions to address th…
View article: The Use of Apabetalone in Reducing Cardiovascular Outcomes, Based on the Current Evidence and Trials
The Use of Apabetalone in Reducing Cardiovascular Outcomes, Based on the Current Evidence and Trials Open
The use of apabetalone, a novel therapeutic agent targeting epigenetic regulation, has been the source of much interest in its ability to subvert major adverse cardiovascular events. Derived from BETonMACE, clinical trials have explored it…
View article: Acute management of massive pulmonary embolism in pregnancy
Acute management of massive pulmonary embolism in pregnancy Open
Key content • Massive pulmonary embolism (PE) during pregnancy or the postpartum period is a rare but potentially lethal event. • Physiological changes in the coagulation system during pregnancy and puerperium would lead to a hypercoagulab…
View article: Commencement of Atorvastatin and Ezetimibe Immediately in Patients Presenting with Acute Coronary Syndrome
Commencement of Atorvastatin and Ezetimibe Immediately in Patients Presenting with Acute Coronary Syndrome Open
Lipids are implicated in the development of coronary atherosclerosis. Achieving a significant reduction in lipid levels remains a crucial aspect of secondary prevention following an acute coronary syndrome event. Novel lipid-lowering thera…
View article: Use of combination therapy is associated with improved LDL cholesterol management: 1-year follow-up results from the European observational SANTORINI study
Use of combination therapy is associated with improved LDL cholesterol management: 1-year follow-up results from the European observational SANTORINI study Open
Aims To assess whether implementation of the 2019 European Society of Cardiology (ESC)/European Atherosclerosis Society (EAS) dyslipidaemia guidelines observed between 2020 and 2021 improved between 2021 and 2022 in the SANTORINI study. Me…
View article: A novel bioreactor platform to apply dynamic load to neonatal lamb living myocardial slices for the study of the regenerative properties of the heart
A novel bioreactor platform to apply dynamic load to neonatal lamb living myocardial slices for the study of the regenerative properties of the heart Open
Background The inability of the myocardium to regenerate is a determining factor in heart failure (HF).Platforms that model cardiac disease require to approximate the in vivo environment and related factors.One such factor is mechanical lo…
View article: Comparison of an Initial Risk-Based Testing Strategy vs Usual Testing in Stable Symptomatic Patients With Suspected Coronary Artery Disease
Comparison of an Initial Risk-Based Testing Strategy vs Usual Testing in Stable Symptomatic Patients With Suspected Coronary Artery Disease Open
Importance Trials showing equivalent or better outcomes with initial evaluation using coronary computed tomography angiography (cCTA) compared with stress testing in patients with stable chest pain have informed guidelines but raise questi…
View article: Deferred Testing in Stable Outpatients With Suspected Coronary Artery Disease
Deferred Testing in Stable Outpatients With Suspected Coronary Artery Disease Open
Importance Guidelines recommend deferral of testing for symptomatic people with suspected coronary artery disease (CAD) and low pretest probability. To our knowledge, no randomized trial has prospectively evaluated such a strategy. Objecti…
View article: The Utility of CT Coronary Angiography in Chronic Total Occlusion Percutaneous Coronary Intervention
The Utility of CT Coronary Angiography in Chronic Total Occlusion Percutaneous Coronary Intervention Open
Chronic total occlusion (CTO) of the coronary arteries is a relatively common finding in routine coronary angiography. Of late, there has been considerable improvement in the success rate of percutaneous intervention for coronary CTO, attr…
View article: Amplified inhibition of atherosclerotic plaque-induced platelet activation by glenzocimab with dual antiplatelet therapy
Amplified inhibition of atherosclerotic plaque-induced platelet activation by glenzocimab with dual antiplatelet therapy Open
Addition of glenzocimab to aspirin and ticagrelor enhances platelet inhibition via multiple mechanisms of atherothrombosis. Compared with a GPIIb/IIIa inhibitor, glenzocimab shares multiple antithrombotic effects, with less inhibition of m…
View article: Assessing opinion on lower LDL-cholesterol lowering, and the role of newer lipid-reducing treatment options
Assessing opinion on lower LDL-cholesterol lowering, and the role of newer lipid-reducing treatment options Open
While statins are the gold standard for lipid-lowering therapies, newer therapies, such as PCSK9 inhibitors, have also demonstrated low-density lipoprotein cholesterol (LDL-C) reduction, but with a similar or better safety profile. Conflic…
View article: Infective endocarditis in dogs in the<scp>UK</scp>: 77 cases (2009‐2019)
Infective endocarditis in dogs in the<span>UK</span>: 77 cases (2009‐2019) Open
Objectives To determine the causative organisms, clinical features and outcome of canine infective endocarditis in the UK. Materials and Methods Medical records of three veterinary referral hospitals were searched for dogs with infective e…
View article: Smartphone and wearable detected atrial arrhythmias in Older Adults: Results of a fully digital European Case finding study
Smartphone and wearable detected atrial arrhythmias in Older Adults: Results of a fully digital European Case finding study Open
Aims Simplified detection of atrial arrhythmias via consumer-electronics would enable earlier therapy in at-risk populations. Whether this is feasible and effective in older populations is not known. Methods and results The fully remote, i…
View article: Positive remodelling of coronary arteries on computed tomography coronary angiogram: an observational study
Positive remodelling of coronary arteries on computed tomography coronary angiogram: an observational study Open
Detection of PR on CTCA is a reliable prognostic indicator of future cardiovascular events and presents a valuable opportunity for initiation of aggressive primary prevention therapy.
View article: P22 A follow up on OSCRIS: single centre evaluation
P22 A follow up on OSCRIS: single centre evaluation Open
Objective Our centre's One Stop Cardio Radiology Integrated Service (OSCRIS) for Computed Tomography Coronary Angiography (CTCA) reporting was commenced in 2012. We have previously demonstrated the efficiency of this system. We undertook s…
View article: Remote Design of a Smartphone and Wearable Detected Atrial Arrhythmia in Older Adults Case Finding Study: Smart in OAC – AFNET 9
Remote Design of a Smartphone and Wearable Detected Atrial Arrhythmia in Older Adults Case Finding Study: Smart in OAC – AFNET 9 Open
Introduction Screening for atrial fibrillation and timely initiation of oral anticoagulation, rhythm management, and treatment of concomitant cardiovascular conditions can improve outcomes in high-risk populations. Whether wearables can fa…
View article: Interactions Between Atrial Fibrillation and Natriuretic Peptide in Predicting Heart Failure Hospitalization or Cardiovascular Death
Interactions Between Atrial Fibrillation and Natriuretic Peptide in Predicting Heart Failure Hospitalization or Cardiovascular Death Open
Background Natriuretic peptides are routinely quantified to diagnose heart failure (HF). Their concentrations are also elevated in atrial fibrillation (AF). To clarify their value in predicting future cardiovascular events, we measured nat…
View article: GPVI inhibition by glenzocimab synergistically inhibits atherosclerotic plaque-induced platelet activation when combined with conventional dual antiplatelet therapy
GPVI inhibition by glenzocimab synergistically inhibits atherosclerotic plaque-induced platelet activation when combined with conventional dual antiplatelet therapy Open
Introduction Aspirin and a potent platelet P2Y12 inhibitor, such as prasugrel or ticagrelor, are not always sufficient to prevent thrombus formation in patients with ST-elevation MI (STEMI), leading to “slow flow” or “no reflow” effects af…
View article: Fractional flow reserve derived from computed tomography coronary angiography in the assessment and management of stable chest pain: the FORECAST randomized trial
Fractional flow reserve derived from computed tomography coronary angiography in the assessment and management of stable chest pain: the FORECAST randomized trial Open
Aims Fractional flow reserve (FFRCT) using computed tomography coronary angiography (CTCA) determines both the presence of coronary artery disease and vessel-specific ischaemia. We tested whether an evaluation strategy based on FFRCT would…
View article: The EXCEL Trial: The Interventionalists’ Perspective
The EXCEL Trial: The Interventionalists’ Perspective Open
Left main stem (LMS) disease is identified in up to 5% of diagnostic angiography cases, and is associated with significant morbidity and mortality due to the proportion of myocardium it subtends. In the past 10 years, there has been a sign…