Simon Chen
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View article: Determinants of Intergrader Agreement for Key Retinal Photography and OCT Biomarkers in AMD
Determinants of Intergrader Agreement for Key Retinal Photography and OCT Biomarkers in AMD Open
Implementing consensus definitions and protocols can improve agreement and strengthen the clinical utility of OCT biomarkers in AMD.
View article: Localising OCTA changes induced by the isometric hand-grip test to the superficial retina in neovascular age-related macular degeneration
Localising OCTA changes induced by the isometric hand-grip test to the superficial retina in neovascular age-related macular degeneration Open
Purpose This study uses optical coherence tomography angiography (OCTA) topographical cluster analysis to localise where vascular changes occur during the isometric hand-grip test (IHGT) in eyes with neovascular age-related macular degener…
View article: Semi-empirical metadynamics simulations for chemical glycosylation reactions
Semi-empirical metadynamics simulations for chemical glycosylation reactions Open
Glycosylation, the formation of glycosidic bonds, is a central yet challenging step in the chemical synthesis of complex carbohydrates due to its intricate regio- and stereochemical control. This study explores explicitly solvated, semi-em…
View article: Hemodynamic and electrophysiological progression of the Rose Bengal photothrombotic stroke model in mice: vasoactive properties of Rose Bengal, tissue heating, wavelength optimization, and sex differences in lesion volume
Hemodynamic and electrophysiological progression of the Rose Bengal photothrombotic stroke model in mice: vasoactive properties of Rose Bengal, tissue heating, wavelength optimization, and sex differences in lesion volume Open
The photothrombotic stroke model is gaining popularity due to its relative simplicity, minimal invasiveness, and clinical relevance. Photothrombosis involves the delivery of an intravascular photosensitizer (Rose Bengal) followed by its ph…
View article: Updated Integrated Safety Analysis of Ritlecitinib Over 72 Months In Patients With Alopecia Areata From the ALLEGRO Clinical Trial Program
Updated Integrated Safety Analysis of Ritlecitinib Over 72 Months In Patients With Alopecia Areata From the ALLEGRO Clinical Trial Program Open
Introduction: Ritlecitinib, an oral, selective JAK3/TEC family kinase inhibitor, demonstrated efficacy and safety up to 48 weeks in patients aged ≥12 years with alopecia areata (AA) in the ALLEGRO phase 2b/3 study (NCT03732807). This updat…
View article: Proposal of a Simpler Eye‐Level Risk Model Incorporating Reticular Pseudodrusen for the Clinical Prediction of Late <scp>Age‐Related Macular Degeneration</scp>
Proposal of a Simpler Eye‐Level Risk Model Incorporating Reticular Pseudodrusen for the Clinical Prediction of Late <span>Age‐Related Macular Degeneration</span> Open
Background The updated simplified AREDS risk model predicts progression to late age‐related macular degeneration (AMD) by person, describing up to nine observations across both eyes and 10 annual risk scores (0–4, with/without reticular ps…
View article: Longitudinal and Exploratory Genome-Wide Analysis in Alopecia AreaTA (LEGAATA): A Study of FinnGen Participants
Longitudinal and Exploratory Genome-Wide Analysis in Alopecia AreaTA (LEGAATA): A Study of FinnGen Participants Open
None.
View article: Drone-Based Antenna Beam Calibration in the High Arctic
Drone-Based Antenna Beam Calibration in the High Arctic Open
The development of low-frequency radio astronomy experiments for detecting 21-cm line emission from hydrogen presents new opportunities for creative solutions to the challenge of characterizing an antenna beam pattern. The Array of Long Ba…
View article: The impact of the COVID-19 pandemic on cardiovascular disease prevention and corresponding geographical inequalities in England: interrupted time series analysis
The impact of the COVID-19 pandemic on cardiovascular disease prevention and corresponding geographical inequalities in England: interrupted time series analysis Open
Background There has been disruption to the detection and management of those with hypertension and atrial fibrillation (AF) during the COVID-19 pandemic. This is likely to vary geographically and could have implications for future mortali…
View article: Investigating Players' Social Interactions in IOT Board Games
Investigating Players' Social Interactions in IOT Board Games Open
This study aims to investigate the impact of integrating Internet of Things (IoT) technology with board games to enhance social interaction among players. Given the widespread application of IoT in various domains, incorporating it into bo…
View article: Association of a calcium channel blocker and diuretic prescribing cascade with adverse events: A population‐based cohort study
Association of a calcium channel blocker and diuretic prescribing cascade with adverse events: A population‐based cohort study Open
Background Prescribing cascades occur when a drug adverse event is misinterpreted as a new medical condition and a second, potentially unnecessary drug, is prescribed to treat the adverse event. The population‐level consequences of prescri…
View article: Disability and in-hospital breastfeeding practices and supports in Ontario, Canada: a population-based study
Disability and in-hospital breastfeeding practices and supports in Ontario, Canada: a population-based study Open
National Institutes of Health and the Canada Research Chairs Program.
View article: Neonatal Outcomes of Mothers With a Disability
Neonatal Outcomes of Mothers With a Disability Open
OBJECTIVES To assess the risk of neonatal complications among women with a disability. METHODS This population-based cohort study comprised all hospital singleton livebirths in Ontario, Canada from 2003 to 2018. Newborns of women with a ph…
View article: How Getting Friendly with Bacteria Can Promote Student Appreciation of Microbial Diversity and Their Civic Scientific Literacy
How Getting Friendly with Bacteria Can Promote Student Appreciation of Microbial Diversity and Their Civic Scientific Literacy Open
ePortfolios are digital repositories where students can curate papers, projects, and reflections from individual or multiple courses across the disciplines and in a variety of formats to showcase their learning. This transparent and portab…
View article: A Systematic Review and Meta-analysis of Total Ankle Arthroplasty or Ankle Arthrodesis for Treatment of Osteoarthritis in Patients With Diabetes
A Systematic Review and Meta-analysis of Total Ankle Arthroplasty or Ankle Arthrodesis for Treatment of Osteoarthritis in Patients With Diabetes Open
Background: End-stage ankle osteoarthritis often requires one of 2 major surgical procedures: total ankle arthroplasty or ankle arthrodesis. Although the gold standard has been arthrodesis, patients with diabetes represent a unique cohort …
View article: Determinants of Hospital Use and Physician Services Among Adults With a History of Homelessness
Determinants of Hospital Use and Physician Services Among Adults With a History of Homelessness Open
Background: People experiencing homelessness have diverse patterns of healthcare use. This study examined the distribution and determinants of healthcare encounters among adults with a history of homelessness. Methods: Administrative healt…
View article: The role of directional atherectomy in critical-limb ischemia
The role of directional atherectomy in critical-limb ischemia Open
Background: Our aim was to review the current literature of the use of directional atherectomy (DA) in the treatment of lower extremity critical-limb ischemia. Methods: A search for relevant literature was performed in PubMed and PubMed Ce…
View article: Maternal Schizophrenia, Skin-to-Skin Contact, and Infant Feeding Initiation
Maternal Schizophrenia, Skin-to-Skin Contact, and Infant Feeding Initiation Open
Background The World Health Organization recommends mothers and infants be in direct skin-to-skin contact immediately after birth and initiate breastfeeding as soon as possible. Little is known in women with schizophrenia. Methods We condu…
View article: Association of Preexisting Disability With Severe Maternal Morbidity or Mortality in Ontario, Canada
Association of Preexisting Disability With Severe Maternal Morbidity or Mortality in Ontario, Canada Open
In this study, women with a preexisting disability were more likely to experience severe maternal morbidity or mortality. Preconception and perinatal care provisions should be considered among women with a disability to mitigate the risk o…
View article: Health characteristics of reproductive-aged autistic women in Ontario: A population-based, cross-sectional study
Health characteristics of reproductive-aged autistic women in Ontario: A population-based, cross-sectional study Open
While an increasing number of girls and women are being identified with autism, we know little about the health of reproductive-aged autistic women. Our objectives were to (1) describe health characteristics of reproductive-aged autistic w…
View article: Test et calibrations technologiques avec PICO-0.1 pour les futurs détecteurs de chambre à bulle de matière sombre de PICO
Test et calibrations technologiques avec PICO-0.1 pour les futurs détecteurs de chambre à bulle de matière sombre de PICO Open
Parmi les douzaines d’expériences qui visent à découvrir la matière sombre, l’expérience de détection directe PICO utilise des détecteurs à liquide surchauffé comme moyen pour s’y prendre. La chambre à bulle PICO-40L remplie de C3F8, prése…
View article: Health Care Use and Costs of Children, Adolescents, and Young Adults With Somatic Symptom and Related Disorders
Health Care Use and Costs of Children, Adolescents, and Young Adults With Somatic Symptom and Related Disorders Open
This study found that children and young people with somatic symptom and related disorders frequently used the health system with substantial health system costs before and after diagnosis. Many of these patients did not receive physician-…
View article: Factors Influencing the Mental Health of Firefighters in Shantou City, China
Factors Influencing the Mental Health of Firefighters in Shantou City, China Open
Xiaojun Chen,1 Lishao Zhang,1 Zhekuang Peng,2 Shaoxing Chen1 1Department of Hospital Office, The First Affiliated Hospital of Shantou University Medical College, Shantou, People’s Republic of China; 2Department of Public Health, The …
View article: Astragalus Polysaccharide Attenuated Iron Overload-Induced Dysfunction of Mesenchymal Stem Cells via Suppressing Mitochondrial ROS
Astragalus Polysaccharide Attenuated Iron Overload-Induced Dysfunction of Mesenchymal Stem Cells via Suppressing Mitochondrial ROS Open
Background/Aims: Bone marrow-derived mesenchymal stem cells (BMSCs) have the ability to differentiate into multilineage cells such as osteoblasts, chondrocytes, and cardiomyocytes. Dysfunction of BMSCs in response to pathological stimuli p…