Dmitriy V. Ivashchenko
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View article: Associations of CYP3A4*22 and CYP3A5*3 with the effectiveness and safety of therapy for conduct disorder in children
Associations of CYP3A4*22 and CYP3A5*3 with the effectiveness and safety of therapy for conduct disorder in children Open
Introduction . Polymorphisms of CYP3A4 and CYP3A5 genes are currently poorly understood as biomarkers of antipsychotic efficacy and safety. There are no studies of these factors in children taking antipsychotics for conduct disorder. Aim .…
View article: Editorial: The utilization of bench-to-bedside approaches in pharmacogenomics
Editorial: The utilization of bench-to-bedside approaches in pharmacogenomics Open
EDITORIAL article Front. Pharmacol., 13 June 2023Sec. Pharmacogenetics and Pharmacogenomics Volume 14 - 2023 | https://doi.org/10.3389/fphar.2023.1234219
View article: Genetic markers associated with resistance to radioiodine therapy in thyroid cancer patients: Prospective cohort study
Genetic markers associated with resistance to radioiodine therapy in thyroid cancer patients: Prospective cohort study Open
Background. The indication for radiotherapy in oncological practice are metastases of differentiated thyroid cancer after thyroidectomy, the presence of distant metastases, or stage N1b, or negative dynamics of blood thyroglobulin levels a…
View article: Pharmacogenetic markers to predict safety of antipsychotics in adolescents experiencing acute psychotic episodes
Pharmacogenetic markers to predict safety of antipsychotics in adolescents experiencing acute psychotic episodes Open
Introduction There are relatively fewer pharmacogenetic studies of antipsychotics in adolescents than in adult patients. The development of personalized pharmacotherapy is promising. Objectives Identify the most significant pharmacogenetic…
View article: Off-label antipsychotics prescription to adolescents with acute psychotic episodes does not cause adverse drug reactions
Off-label antipsychotics prescription to adolescents with acute psychotic episodes does not cause adverse drug reactions Open
Antipsychotics are often used to treat children and adolescents. Because of their age, there are a lot of off-label prescribed antipsychotics in that population. However, the off-label use of medications is considered to be potentially uns…
View article: Влияние носительства клинически значимых аллельных вариантов генов CES1, PON1, ABCG2, CYP4F2, CYP3A4, IGTB3, P2Y12, PEAR1, B4GALT2 на антиагрегантное действие клопидогрела и клинические исходы пациентов с ОКС и фибрилляцией предсердий
Влияние носительства клинически значимых аллельных вариантов генов CES1, PON1, ABCG2, CYP4F2, CYP3A4, IGTB3, P2Y12, PEAR1, B4GALT2 на антиагрегантное действие клопидогрела и клинические исходы пациентов с ОКС и фибрилляцией предсердий Open
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View article: Efficacy and safety of antipsychotics in adolescents with an acute psychotic episode in relation to the activity of CYP3A and CYP2D6 isoenzymes
Efficacy and safety of antipsychotics in adolescents with an acute psychotic episode in relation to the activity of CYP3A and CYP2D6 isoenzymes Open
Antipsychotics are a first-line treatment for psychotic disorders. The cytochrome P450 isoenzymes CYP3A4/5 and CYP2D6 metabolize most antipsychotics. The activity of these isoenzymes in children changes with maturation, so it is different …
View article: Current and future use of umifenovir in patients with COVID-19
Current and future use of umifenovir in patients with COVID-19 Open
At the time of print, the evidence for using umifenovir in COVID-19 is mainly theoretical. The published clinical trials have contradicting results. The decision to use umifenovir in COVID-19 should be individualized, considering the “expe…
View article: The polymorphic variants DRD2 rs1800497 and ABCB1 3435C>T are associated with antipsychotic safety parameters in adolescents with an acute psychotic episode: the results of a pilot study
The polymorphic variants DRD2 rs1800497 and ABCB1 3435C>T are associated with antipsychotic safety parameters in adolescents with an acute psychotic episode: the results of a pilot study Open
Children and adolescents are more likely than adults to experience adverse side effects when taking antipsychotics. Pharmacogenetic testing allows one to more accurately choose the initial dose of a drug. The genes of pharmacokinetic facto…
View article: New Pharmacogenetic Markers to Predict the Risk of Bleeding During Taking of Direct Oral Anticoagulants
New Pharmacogenetic Markers to Predict the Risk of Bleeding During Taking of Direct Oral Anticoagulants Open
Aim . To search for new pharmacogenetic biomarkers of bleeding risk in patients taking rivaroxaban and dabigatran for different indications: atrial fibrillation, endoprosthesis of large joints of lower limbs. Material and methods . The stu…
View article: Supporting frontline clinicians in the time of the pandemic: Rapid response pharmacology team
Supporting frontline clinicians in the time of the pandemic: Rapid response pharmacology team Open
Since the early days of the COVID-19 pandemic, a long range of medications have been tried in the fight against the novel coronavirus: antivirals, antimalarial drugs, antibiotics, steroids, and numerous biologicals. None of them were licen…
View article: Pharmacogenetics of the safety of phenazepam in alcohol withdrawal syndrome: haplotype and combinatorial analyses of polymorphic variants in the pharmacokinetic factor genes
Pharmacogenetics of the safety of phenazepam in alcohol withdrawal syndrome: haplotype and combinatorial analyses of polymorphic variants in the pharmacokinetic factor genes Open
Phenazepam is a benzodiazepine tranquilizer that is widely used in Russia. The drug is metabolized by cytochrome P450 3A (CYP3A) isozymes. Since their substrates have an affinity for P-glycoprotein, the polymorphic variants in the ABCB1 ge…
View article: <p><em>CYP2C19*17</em> May Increase the Risk of Death Among Patients with an Acute Coronary Syndrome and Non-Valvular Atrial Fibrillation Who Receive Clopidogrel and Rivaroxaban</p>
<em>CYP2C19*17</em> May Increase the Risk of Death Among Patients with an Acute Coronary Syndrome and Non-Valvular Atrial Fibrillation Who Receive Clopidogrel and Rivaroxaban Open
In situations of double or triple antithrombotic rivaroxaban and clopidogrel therapy among patients with atrial fibrillation and acute coronary syndrome, the genetic factors associated with bleeding complications risk (CYP2C19*17) m…
View article: Pharmacogenetics biomarkers of antipsychotics’ safety in adolescents with acute psychotic episode
Pharmacogenetics biomarkers of antipsychotics’ safety in adolescents with acute psychotic episode Open
Currently, there is a lack of pharmacogenetic research of antipsychotics’ safety in children and adolescents with acute psychotic episodes. Genetic polymorphisms of CYP2D6 and ABCB1 are the most likely candidates for such studies. AIM.To e…
View article: No association of rs1065852 and rs3892097 polymorphisms gene CYP2D6 with treatment resistant schizophrenia
No association of rs1065852 and rs3892097 polymorphisms gene CYP2D6 with treatment resistant schizophrenia Open
According to modern data, about a third of patients suffering from schizophrenia are considered treatment resistant. The metabolism of about 20% of medicines and mainly psychotropic drugs is caused by the isoenzyme CYP2D6. This article pre…
View article: Clinical pharmacology technologies for personalization of cardiovascular diseases drug treatment: focus on direct oral anticoagulants
Clinical pharmacology technologies for personalization of cardiovascular diseases drug treatment: focus on direct oral anticoagulants Open
One of the main causes for adverse reactions development is not taking into account the pharmacokinetics of drugs and the dose. Pharmacokinetics of drugs is mostly defined by the cytochrome P-450 isoenzymes activity, carboxylesterases and …
View article: Multi-Ethnic Analysis of Cardiac Pharmacogenetic Markers of Cytochrome P450 and Membrane Transporters Genes in the Russian Population
Multi-Ethnic Analysis of Cardiac Pharmacogenetic Markers of Cytochrome P450 and Membrane Transporters Genes in the Russian Population Open
Aim. To summarize Russian studies using pharmacogenetic testing as applied to cardiology. Material and methods . The authors conducted an online search for articles in December 2018 using the following databases: PubMed, Google Scholar, eL…
View article: Falls in elderly patients with comorbidity, which were prescribed combined application of psychotropic and cardiovascular medicines
Falls in elderly patients with comorbidity, which were prescribed combined application of psychotropic and cardiovascular medicines Open
The article discusses aspects of drug-induced falls in elderly comorbid patients against the background of polypragmasy and also assesses the role of drug interactions that are highly dangerous according to the risk of falling. A drug audi…
View article: Tapering (deprescribing) of benzodiazepine tranquilizers
Tapering (deprescribing) of benzodiazepine tranquilizers Open
Deprescribing is the opposite of prescribing drugs, the purpose of which is to improve quality of life and reduce the risk of adverse drug reactions. The paper considers the process of deprescribing benzodiazepines. It analyzes relevant st…
View article: Ассоциация полиморфизмов rs6265 BDNF и CYP2D6*4 с когнитивными функциями у пациентов с проявлениями терапевтической резистентности при шизофрении
Ассоциация полиморфизмов rs6265 BDNF и CYP2D6*4 с когнитивными функциями у пациентов с проявлениями терапевтической резистентности при шизофрении Open
Изучение влияния полиморфизмов rs6265 BDNF , Taq1A DRD2 , Ser9Gly DRD3 , T102C HTR2A , CYP2D6*4 и CYP2D6*10 на когнитивные функции у пациентов с шизофренией, в зависимости от наличия и отсутствия проявлений терапевтичес…
View article: Global trigger tool value for revealing of unwanted events related to medical care in pediatrics
Global trigger tool value for revealing of unwanted events related to medical care in pediatrics Open
Global trigger tool algorithm was described by this article. Global triggers are the special tools to increase inpatients’ safety, which is based on identifying of unwanted events’ high-risk indicators in medical documents. Global trigger …
View article: IMPACT OF CYP3A5, CYP2C9, CYP2C19, AND CYP2D6 POLYMORPHISMS ON PHENAZEPAM SAFETY IN PATIENTS WITH ALCOHOL WITHDRAWAL SYNDROME
IMPACT OF CYP3A5, CYP2C9, CYP2C19, AND CYP2D6 POLYMORPHISMS ON PHENAZEPAM SAFETY IN PATIENTS WITH ALCOHOL WITHDRAWAL SYNDROME Open
Introduction: Phenazepam is the Russian original benzodiazepine tranquilizer. We conducted first pharmacogenetic study on Phenazepam’s safety in patients with alcohol withdrawal syndrome. Isoenzymes CYP3A4, CYP3A5, CYP2C9, and CYP2C19 are …
View article: Which cytochrome P450 metabolizes phenazepam? Step by step<i>in silico</i>,<i>in vitro</i>, and<i>in vivo</i>studies
Which cytochrome P450 metabolizes phenazepam? Step by step<i>in silico</i>,<i>in vitro</i>, and<i>in vivo</i>studies Open
Background: Phenazepam (bromdihydrochlorphenylbenzodiazepine) is the original Russian benzodiazepine tranquilizer belonging to 1,4-benzodiazepines. There is still limited knowledge about phenazepam’s metabolic liver pathways and other phar…
View article: Pharmacogenetic evaluation of adverse events’ risk in patients with alcohol withdrawal syndrome taking bromdihydrochlorphenylbenzodiazepine: The role of CYP2C19 gene polymorphisms
Pharmacogenetic evaluation of adverse events’ risk in patients with alcohol withdrawal syndrome taking bromdihydrochlorphenylbenzodiazepine: The role of CYP2C19 gene polymorphisms Open
Introduction. Bromdihydrochlorphenylbenzodiazepine is the Russian original tranquilizer which widely using in psychiatry, narcology, neurology and general medicine. Particularly, that drug prescribing for patients with alcohol withdrawal s…
View article: BIOLOGICAL MARKERS OF THE ANTIEPILEPTIC DRUGS EFFICACY AND SAFETY: PHARMACOGENETICS AND PHARMACOKINETICS
BIOLOGICAL MARKERS OF THE ANTIEPILEPTIC DRUGS EFFICACY AND SAFETY: PHARMACOGENETICS AND PHARMACOKINETICS Open
БИОЛОГИЧЕСКИЕ МАРКЕРЫ ЭФФЕКТИВНОСТИ И БЕЗОПАСНОСТИ ПРОТИВОЭПИЛЕПТИЧЕСКИХ ПРЕПАРАТОВ: ФАРМАКОГЕНЕТИКА И ФАРМАКОКИНЕТИКАНасырова Р. Ф. 1 , Сивакова Н
View article: Role of nitric oxide and related molecules in schizophrenia pathogenesis: biochemical, genetic and clinical aspects
Role of nitric oxide and related molecules in schizophrenia pathogenesis: biochemical, genetic and clinical aspects Open
Currently, schizophrenia is considered a multifactorial disease. Over the past 50 years, many investigators have considered the role of toxic free radicals in the etiology of schizophrenia. This is an area of active research which is still…
View article: Pharmacogenetic-based risk assessment of antipsychotic-induced extrapyramidal symptoms
Pharmacogenetic-based risk assessment of antipsychotic-induced extrapyramidal symptoms Open
"Typical" antipsychotics remain the wide-prescribed drugs in modern psychiatry. But these drugs are associated with development of extrapyramidal symptoms (EPS). Preventive methods of EPS are actively developed and they concentrate on pers…
View article: Dopamine neurotransmission of peripheral blood lymphocytes is a potential biomarker of psychiatric and neurological disorders
Dopamine neurotransmission of peripheral blood lymphocytes is a potential biomarker of psychiatric and neurological disorders Open
Current literature on a role of dopamine in the development of mental and neurological disorders suggests that the discovery of endogenous dopamine in peripheral blood lymphocytes gave rise to a new line of research. Dopamine receptors are…