Dmitry Grinfeld
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View article: A Multi-Reflection Time-of-Flight Analyzer with a Long Focus Lens
A Multi-Reflection Time-of-Flight Analyzer with a Long Focus Lens Open
Multi-reflection time-of-flight (MR-ToF) analyzers must control the transversal ion dispersion, orthogonal to the axis of reflection, conventionally via periodic refocusing, or more recently the shaped electrode structure adopted by the As…
View article: A High Dynamic Range Ion Detector for the Astral™ Analyzer.
A High Dynamic Range Ion Detector for the Astral™ Analyzer. Open
Reflectron-based time-of-flight analyzers rely on sub-nanosecond detector time response to achieve acceptable resolving power for low-mid mass, multiple ion peaks. With the adoption of multi-reflection analyzers, order of magnitude longer …
View article: The OrbiTOF Mass Analyzer: Time-of-Flight Analysis via an Orbitrap Quadro-Logarithmic Field with Periodic Drift Focusing.
The OrbiTOF Mass Analyzer: Time-of-Flight Analysis via an Orbitrap Quadro-Logarithmic Field with Periodic Drift Focusing. Open
Thermo Scientific™ Orbitrap™ analyzers represent prominent class of high-resolution mass analyzer commonly used in life sciences, and for interrogation of complex samples. Injected ions, trapped within a quadro-logarithmic field, orbit a c…
View article: Full Mass Range ΦSDM Orbitrap Mass Spectrometry for DIA Proteome Analysis
Full Mass Range ΦSDM Orbitrap Mass Spectrometry for DIA Proteome Analysis Open
View article: Crowd Control of Ions in the Astral Analyzer
Crowd Control of Ions in the Astral Analyzer Open
Space charge effects are the Achilles’ heel of all high-resolution ion optical devices. In time-of-flight mass analyzers these may manifest as reduction of resolving power, mass measurement shift, peak coalescence and/or transmission losse…
View article: Proof of Principle for Enhanced Resolution Multi-Pass Methods for the Astral Analyzer
Proof of Principle for Enhanced Resolution Multi-Pass Methods for the Astral Analyzer Open
Multi-pass zoom-mode methods have been described to extend the flight path and resolving power of multi-reflection time-of-flight mass spectrometers, by deflecting exiting ions back into repeat passes through the analyzer. Such methods hav…
View article: A Conjoined Rectilinear Collision Cell and Pulsed Extraction Ion Trap with Auxiliary DC Electrodes
A Conjoined Rectilinear Collision Cell and Pulsed Extraction Ion Trap with Auxiliary DC Electrodes Open
Ion traps are routinely directly coupled to mass analyzers, where they serve to suitably cool and shape an ion population prior to pulsed extraction into the analyzer proper. Such devices benefit from high duty cycle and transmission but s…
View article: Parallelized Acquisition of Orbitrap and Astral Analyzers Enables High-Throughput Quantitative Analysis
Parallelized Acquisition of Orbitrap and Astral Analyzers Enables High-Throughput Quantitative Analysis Open
The growing trend toward high-throughput proteomics demands rapid liquid chromatography-mass spectrometry (LC-MS) cycles that limit the available time to gather the large numbers of MS/MS fragmentation spectra required for identification. …
View article: A Conjoined Rectilinear Collision Cell and Pulsed Extraction Ion Trap with Auxiliary DC Electrodes.
A Conjoined Rectilinear Collision Cell and Pulsed Extraction Ion Trap with Auxiliary DC Electrodes. Open
Ion traps are routinely directly coupled to mass analyzers, where they serve to suitably cool and shape an ion population prior to pulsed extraction into the analyzer proper. Such devices benefit from high duty cycle and transmission but s…
View article: Parallelized Acquisition of Orbitrap and Astral Analyzers Enables High-Throughput Quantitative Analysis
Parallelized Acquisition of Orbitrap and Astral Analyzers Enables High-Throughput Quantitative Analysis Open
The growing trend towards high-throughput proteomics demands rapid liquid chromatography-mass spectrometry (LC-MS) cycles that limit the available time to gather the large numbers of MS/MS fragmentation spectra required for identification.…
View article: Expanding Orbitrap collision cross section measurements to native protein applications through kinetic energy and signal decay analysis
Expanding Orbitrap collision cross section measurements to native protein applications through kinetic energy and signal decay analysis Open
The measurement of collision cross sections (CCS) offers supplemental information about sizes and conformations of ions beyond mass analysis alone. We have previously shown that CCSs can be determined directly from the time-domain transien…
View article: Experimental strategies to improve drug-target identification in mass spectrometry-based thermal stability assays
Experimental strategies to improve drug-target identification in mass spectrometry-based thermal stability assays Open
View article: Expanding Orbitrap collision cross section measurements to native protein applications through kinetic energy and signal decay analysis
Expanding Orbitrap collision cross section measurements to native protein applications through kinetic energy and signal decay analysis Open
The measurement of collision cross sections (CCS) offers supplemental information about sizes and conformations of ions beyond mass analysis alone. We have previously shown that CCSs can be determined directly from the time-domain transien…
View article: Expanding Orbitrap collision cross section measurements to native protein applications through kinetic energy and signal decay analysis
Expanding Orbitrap collision cross section measurements to native protein applications through kinetic energy and signal decay analysis Open
The measurement of collision cross sections (CCS) offers supplemental information about sizes and conformations of ions beyond mass analysis alone. We have previously shown that CCSs can be determined directly from the time-domain transien…
View article: A Novel Family of Quadrupole-Orbitrap Mass Spectrometers for a Broad Range of Analytical Applications
A Novel Family of Quadrupole-Orbitrap Mass Spectrometers for a Broad Range of Analytical Applications Open
The rapidly increasing adoption of high-resolution accurate-mass methods in analytical laboratories has fueled demand for instruments that combine high performance and reliability with small size and greater ease-of-use. This paper present…
View article: Determination of Collision Cross-Sections of Protein Ions in an Orbitrap Mass Analyzer
Determination of Collision Cross-Sections of Protein Ions in an Orbitrap Mass Analyzer Open
We demonstrate a method for determining the collision cross-sections (CCSs) of protein ions based on the decay rate of the time-domain transient signal from an Orbitrap mass analyzer. Multiply charged ions of ubiquitin, cytochrome c, and m…
View article: Determination of Collision Cross-Sections of Protein Ions in an Orbitrap Mass Analyzer
Determination of Collision Cross-Sections of Protein Ions in an Orbitrap Mass Analyzer Open
Postprint of publication in Analytical Chemistry 2018: https://pubs.acs.org/doi/10.1021/acs.analchem.8b00724
View article: The 3D OrbiSIMS—label-free metabolic imaging with subcellular lateral resolution and high mass-resolving power
The 3D OrbiSIMS—label-free metabolic imaging with subcellular lateral resolution and high mass-resolving power Open
View article: The 3D OrbiSIMS – Label-Free Metabolic Imaging with Sub-cellular Lateral Resolution and High Mass Resolving Power
The 3D OrbiSIMS – Label-Free Metabolic Imaging with Sub-cellular Lateral Resolution and High Mass Resolving Power Open
We have developed the 3D OrbiSIMS for label-free biomedical imaging. It has an unparalleled simultaneous combination of spatial resolution (under 200 nm for inorganics and under 1.5 µm for biomolecules) and mass resolving power of > 240,00…
View article: Control of Aberration and Space-Charge Effects in the Orbitrap Mass Analyzer
Control of Aberration and Space-Charge Effects in the Orbitrap Mass Analyzer Open
Journal Article Control of Aberration and Space-Charge Effects in the Orbitrap Mass Analyzer Get access Dmitry Grinfeld, Dmitry Grinfeld Thermo Fisher Scientific, Bremen, Germany Search for other works by this author on: Oxford Academic Go…