Dmitry Rinberg
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View article: Mice and humans evaluate odor stimulus strength using common psychophysical principles
Mice and humans evaluate odor stimulus strength using common psychophysical principles Open
Sensory systems translate physical stimuli from the environment—such as light, sound, or chemicals—into signals that the brain can interpret. Across these systems, the amplitude of a stimulus is represented by its perceived intensity. Alth…
View article: Rapid temporal processing in the olfactory bulb underlies concentration invariant odor identification and signal decorrelation
Rapid temporal processing in the olfactory bulb underlies concentration invariant odor identification and signal decorrelation Open
In a dynamic environment, sensory systems must filter out irrelevant information to construct a stable percept. Animals who rely on smell need to identify and discriminate odors despite fluctuations in concentration, yet odor receptor acti…
View article: Striatal and hippocampal contributions to instrumental learning in the mouse using high-resolution behavioral monitoring and fMRI
Striatal and hippocampal contributions to instrumental learning in the mouse using high-resolution behavioral monitoring and fMRI Open
The mammalian brain orchestrates goal-directed behavior through complex interactions between multiple memory systems, with the striatum and hippocampus playing pivotal interrelated roles. A central open question is the extent to which dist…
View article: Data Science in Olfaction
Data Science in Olfaction Open
Advances in neural sensing technology are making it possible to observe the olfactory process in great detail. In this paper, we conceptualize smell from a Data Science and AI perspective, that relates the properties of odorants to how the…
View article: The primacy model and the structure of olfactory space
The primacy model and the structure of olfactory space Open
Understanding sensory processing involves relating the stimulus space, its neural representation, and perceptual quality. In olfaction, the difficulty in establishing these links lies partly in the complexity of the underlying odor input s…
View article: Data Science In Olfaction
Data Science In Olfaction Open
Advances in neural sensing technology are making it possible to observe the olfactory process in great detail. In this paper, we conceptualize smell from a Data Science and AI perspective, that relates the properties of odorants to how the…
View article: Illuminating Neural Computation Using Precision Optogenetics-Controlled Synthetic Perception
Illuminating Neural Computation Using Precision Optogenetics-Controlled Synthetic Perception Open
Connecting neuronal activity to perception requires tools that can probe neural codes at cellular and circuit levels, paired with sensitive behavioral measures. In this chapter, we present an overview of current methods for connecting neur…
View article: A behavioral paradigm for measuring perceptual distances in mice
A behavioral paradigm for measuring perceptual distances in mice Open
Perceptual similarities between a specific stimulus and other stimuli of the same modality provide valuable information about the structure and geometry of sensory spaces. While typically assessed in human behavioral experiments, perceptua…
View article: Across-animal odor decoding by probabilistic manifold alignment
Across-animal odor decoding by probabilistic manifold alignment Open
Identifying the common structure of neural dynamics across subjects is key for extracting unifying principles of brain computation and for many brain machine interface applications. Here, we propose a novel probabilistic approach for align…
View article: A behavioral paradigm for measuring perceptual distances in mice
A behavioral paradigm for measuring perceptual distances in mice Open
Perceptual similarities between a specific stimulus and other stimuli of the same modality provide valuable information about the structure and geometry of sensory spaces. While typically a subject of behavioral experiments in humans, perc…
View article: Parent-glomerulus-identified, second order cells olfactory responses to odorants in awake mice.
Parent-glomerulus-identified, second order cells olfactory responses to odorants in awake mice. Open
Mitral/tufted cells recording on actively sniffing mice, while probing responses to m72 receptor ligands, including optogenetically identified putative M72 mitral/tufted cells.If you use this dataset, please cite this repository and the co…
View article: Data and code for Chong, Moroni, et al. (2020) Science: "Manipulating synthetic optogenetic odors reveals the coding logic of olfactory perception"
Data and code for Chong, Moroni, et al. (2020) Science: "Manipulating synthetic optogenetic odors reveals the coding logic of olfactory perception" Open
Behavioral response dataset, mitral cell responses, and code to implement the STM model in Chong, Moroni, Wilson, Shoham, Panzeri and Rinberg (2020) Science. Please contact Edmund Chong ([email protected]) and Monica Moroni (monica.…
View article: Data and code for Chong, Moroni, et al. (2020) Science: "Manipulating synthetic optogenetic odors reveals the coding logic of olfactory perception"
Data and code for Chong, Moroni, et al. (2020) Science: "Manipulating synthetic optogenetic odors reveals the coding logic of olfactory perception" Open
Behavioral response dataset, mitral cell responses, and code to implement the STM model in Chong, Moroni, Wilson, Shoham, Panzeri and Rinberg (2020) Science. Please contact Edmund Chong ([email protected]) and Monica Moroni (monica.…
View article: Manipulating synthetic optogenetic odors reveals the coding logic of olfactory perception
Manipulating synthetic optogenetic odors reveals the coding logic of olfactory perception Open
Ensemble activity and perception The mechanisms by which sensory percepts are encoded in neural ensembles are still incompletely understood. Chong et al. used single-spot optogenetic stimulation to control neuronal activity in mouse olfact…
View article: A mouse bio-electronic nose for sensitive and versatile chemical detection
A mouse bio-electronic nose for sensitive and versatile chemical detection Open
When it comes to simultaneous versatility, speed, and specificity in detecting volatile chemicals, biological olfactory systems far outperform all artificial chemical detection devices. Consequently, the use of trained animals for chemical…
View article: Sniff Olfactometry: Temporal effects on odorant mixture perception in humans
Sniff Olfactometry: Temporal effects on odorant mixture perception in humans Open
There is evidence in mice and honeybees that signals initiated by odorants at the olfactory epithelium arrive downstream in the olfactory bulb between 10 and 200ms later and that these latencies are ligand dependent. It has recently been p…
View article: Sniff Olfactometry: Temporal effects on odorant mixture perception in humans
Sniff Olfactometry: Temporal effects on odorant mixture perception in humans Open
There is evidence in mice and honeybees that signals initiated by odorants at the olfactory epithelium arrive downstream in the olfactory bulb between 10 and 200ms later and that these latencies are ligand dependent. It has recently been p…
View article: Manipulating synthetic optogenetic odors reveals the coding logic of olfactory perception
Manipulating synthetic optogenetic odors reveals the coding logic of olfactory perception Open
How does neural activity generate perception? The spatial identities and temporal latencies of activated units correlate with external sensory features, but finding the principal activity subspace that is consequential for perception, rema…
View article: Discovering precise temporal patterns in large-scale neural recordings through robust and interpretable time warping
Discovering precise temporal patterns in large-scale neural recordings through robust and interpretable time warping Open
Though the temporal precision of neural computation has been studied intensively, a data-driven determination of this precision remains a fundamental challenge. Reproducible spike time patterns may be obscured on single trials by uncontrol…
View article: Deconstructing Odorant Identity via Primacy in Dual Networks
Deconstructing Odorant Identity via Primacy in Dual Networks Open
In the olfactory system, odor percepts retain their identity despite substantial variations in concentration, timing, and background. We study a novel strategy for encoding intensity-invariant stimulus identity that is based on representin…
View article: Sniff Invariant Odor Coding
Sniff Invariant Odor Coding Open
Sampling regulates stimulus intensity and temporal dynamics at the sense organ. Despite variations in sampling behavior, animals must make veridical perceptual judgments about external stimuli. In olfaction, odor sampling varies with respi…
View article: Precise optical probing of perceptual detection
Precise optical probing of perceptual detection Open
Summary Establishing causal links between patterns of neuronal activity and perception is crucial for understanding brain function. Electrical and optogenetic stimulation experiments demonstrated that animals can detect activation of a few…
View article: Single olfactory receptors set odor detection thresholds
Single olfactory receptors set odor detection thresholds Open
In many species, survival depends on olfaction, yet the mechanisms that underlie olfactory sensitivity are not well understood. Here we examine how a conserved subset of olfactory receptors, the trace amine-associated receptors (TAARs), de…
View article: Single olfactory receptors set odor detection thresholds
Single olfactory receptors set odor detection thresholds Open
In many species, survival depends on olfaction, yet the mechanisms that underlie olfactory sensitivity are not well understood. Here, we examine how a conserved subset of olfactory receptors, the trace amine-associated receptors (TAARs) de…