De‐Wei An
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View article: ORTHOPEDIC SURGERY IN THE AGING POPULATION: CHALLENGES AND FUTURE DIRECTIONS
ORTHOPEDIC SURGERY IN THE AGING POPULATION: CHALLENGES AND FUTURE DIRECTIONS Open
The rapid aging of the global population has led to a substantial rise in the demand for orthopedic surgery among elderly patients, particularly for hip, knee, and shoulder arthroplasty. However, age-related physiological decline, comorbid…
View article: RollPacker: Mitigating Long-Tail Rollouts for Fast, Synchronous RL Post-Training
RollPacker: Mitigating Long-Tail Rollouts for Fast, Synchronous RL Post-Training Open
Reinforcement Learning (RL) is a pivotal post-training technique for enhancing the reasoning capabilities of Large Language Models (LLMs). However, synchronous RL post-training often suffers from significant GPU underutilization, referred …
View article: Ventricular-arterial coupling is preserved in prematurely born 11-year-old children but calls for life-long prevention of hemodynamic deterioration
Ventricular-arterial coupling is preserved in prematurely born 11-year-old children but calls for life-long prevention of hemodynamic deterioration Open
Background: Premature birth disrupts the intra-uterine structural and functional maturation of the left ventricle (LV) and arteries. The study investigated the impact of premature birth on ventricular-arterial coupling (VAC), a potential p…
View article: Evaluation of race-free eGFR equations in individuals of different ethnicity
Evaluation of race-free eGFR equations in individuals of different ethnicity Open
The NHANES mortality outcomes support the use of eGFRcys and eGFRcr-cys. However, large intraindividual variability between eGFR estimates may lead to KDIGO eGFR stage misclassification and calls for caution in the op…
View article: Urinary collagen peptides predict mortality
Urinary collagen peptides predict mortality Open
Background Organ fibrosis caused by the presence of excessive extracellular matrix (ECM) is strongly related to mortality. Urinary peptide signatures were reported predictive of death in SARS-CoV-2 and chronic kidney disease. Such signatur…
View article: EVALUATION OF RACE-FREE EGFR EQUATIONS IN INDIVIDUALS OF DIFFERENT ETHNICITY
EVALUATION OF RACE-FREE EGFR EQUATIONS IN INDIVIDUALS OF DIFFERENT ETHNICITY Open
Objective: This study aimed to evaluate the impact of CKD age-defined definition on all-cause mortality and cardiovascular (CV) outcomes in a rural population over 136 months long-term follow-up (2005-2022). Design and method: A total of 1…
View article: Ambulatory blood pressure monitoring, European guideline targets, and cardiovascular outcomes: an individual patient data meta-analysis
Ambulatory blood pressure monitoring, European guideline targets, and cardiovascular outcomes: an individual patient data meta-analysis Open
Background and Aims Hypertension is the predominant modifiable cardiovascular risk factor. This cohort study assessed the association of risk with the percentage of time that the ambulatory blood pressure (ABP) is within the target range (…
View article: A randomised trial comparing usual versus strict home blood pressure control in elderly patients with hypertension: protocol and initial progress
A randomised trial comparing usual versus strict home blood pressure control in elderly patients with hypertension: protocol and initial progress Open
Objective. The optimal level of home blood pressure (HBP) for the prevention of cardiovascular complications is unknown. The Home Blood Pressure Intervention in the Community Trial (HomeBP, [NCT05858944]) is addressing this issue by…
View article: Health risks related to environmental and occupational lead exposure
Health risks related to environmental and occupational lead exposure Open
Lead is a ubiquitous toxic metal. This review summarizes the toxicokinetics and toxicology of lead, and the methods to measure blood lead (BL), summarizes recently published studies, and ends with an appraisal of recent regulations to prot…
View article: Cardiovascular Outcomes and Variability in Plasma Lipid Levels Across Body Mass Index Categories: The ARIC Study
Cardiovascular Outcomes and Variability in Plasma Lipid Levels Across Body Mass Index Categories: The ARIC Study Open
The aim of this study was to investigate associations of cardiovascular outcomes with lipid variability across body mass index categories. We identified 6689 participants (57.1% women) enrolled in the Atherosclerosis Risk In Communities (A…
View article: Association of Total Mortality and Cardiovascular Endpoints With the Timing of the First and Second Systolic Peak of the Aortic Pulse Wave
Association of Total Mortality and Cardiovascular Endpoints With the Timing of the First and Second Systolic Peak of the Aortic Pulse Wave Open
Prognostic significance of the timing in the cardiac cycle of the first (TP1) and second (TP2) systolic peak of the central aortic pulse wave is ill‐defined. Incidence rates and standardized multivariable‐adjusted hazard ratios (HRs) of ad…
View article: Urinary Proteomics and Systems Biology Link Eight Proteins to the Higher Risk of Hypertension and Related Complications in Blacks Versus Whites
Urinary Proteomics and Systems Biology Link Eight Proteins to the Higher Risk of Hypertension and Related Complications in Blacks Versus Whites Open
Blacks are more prone to salt‐sensitive hypertension than Whites. This cross‐sectional analysis of a multi‐ethnic cohort aimed to search for proteins potentially involved in the susceptibility to salt sensitivity, hypertension, and hyperte…
View article: Racial and regional disparities in the risk of noncommunicable disease between sub-Saharan black and European white patients
Racial and regional disparities in the risk of noncommunicable disease between sub-Saharan black and European white patients Open
Objectives: Greater vulnerability of Black vs. White individuals to cardiovascular disease (CVD) and chronic kidney disease (CKD) is well charted in the United States, but studies involving sub-Saharan blacks are scarce. Methods: Baseline …
View article: OSTEO18, a novel urinary proteomic signature, associated with osteoporosis in heart transplant recipients
OSTEO18, a novel urinary proteomic signature, associated with osteoporosis in heart transplant recipients Open
Background Immunosuppressive treatment in heart transplant (HTx) recipient causes osteoporosis. The urinary proteomic profile (UPP) includes peptide fragments derived from the bone extracellular matrix. Purpose Study aims were to develop a…
View article: Effects of spironolactone on exercise blood pressure in patients at increased risk of developing heart failure: report from the HOMAGE trial
Effects of spironolactone on exercise blood pressure in patients at increased risk of developing heart failure: report from the HOMAGE trial Open
View article: Heart rate reactivity, recovery, and endurance of the incremental shuttle walk test in patients prone to heart failure
Heart rate reactivity, recovery, and endurance of the incremental shuttle walk test in patients prone to heart failure Open
Aims Few randomized trials assessed the changes over time in the chronotropic heart rate (HR) reactivity (CHR), HR recovery (HRR) and exercise endurance (EE) in response to the incremental shuttle walk test (ISWT). We addressed this issue …
View article: An outcome-driven threshold for pulse pressure amplification
An outcome-driven threshold for pulse pressure amplification Open
View article: Efficacy of antihypertensive treatment for target organ protection in patients with masked hypertension (ANTI-MASK): a multicentre, double-blind, placebo-controlled trial
Efficacy of antihypertensive treatment for target organ protection in patients with masked hypertension (ANTI-MASK): a multicentre, double-blind, placebo-controlled trial Open
View article: Urinary proteomic signature of mineralocorticoid receptor antagonism by spironolactone: evidence from the HOMAGE trial
Urinary proteomic signature of mineralocorticoid receptor antagonism by spironolactone: evidence from the HOMAGE trial Open
Objective Heart failure (HF) is characterised by collagen deposition. Urinary proteomic profiling (UPP) followed by peptide sequencing identifies parental proteins, for over 70% derived from collagens. This study aimed to refine understand…
View article: Lead-associated mortality in the US 1999–2020: a time-stratified analysis of a national cohort
Lead-associated mortality in the US 1999–2020: a time-stratified analysis of a national cohort Open
Objectives: We undertook time-stratified analyses of the National Health and Nutrition Examination Survey in the US to assess time trends (1999–2020) in the associations of blood lead (BL) with blood pressure, mortality, the BL-associated …
View article: Mortality and Cardiovascular End Points In Relation to the Aortic Pulse Wave Components: An Individual-Participant Meta-Analysis
Mortality and Cardiovascular End Points In Relation to the Aortic Pulse Wave Components: An Individual-Participant Meta-Analysis Open
BACKGROUND: Wave separation analysis enables individualized evaluation of the aortic pulse wave components. Previous studies focused on the pressure height with overall positive but differing results. In the present analysis, we assessed t…
View article: OSTEO18, a novel urinary proteomic signature, associated with osteoporosis in heart transplant recipients
OSTEO18, a novel urinary proteomic signature, associated with osteoporosis in heart transplant recipients Open
View article: Osteoporosis in Relation to a Bone-Related Aging Biomarker Derived from the Urinary Proteomic Profile: A Population Study
Osteoporosis in Relation to a Bone-Related Aging Biomarker Derived from the Urinary Proteomic Profile: A Population Study Open
Screening for and prevention of osteoporosis and osteoporotic fractures is imperative, given the high burden on individuals and society. This study constructed and validated an aging-related biomarker derived from the urinary proteomic pro…
View article: Association of Air Pollution with a Urinary Biomarker of Biological Aging and Effect Modification by Vitamin K in the FLEMENGHO Prospective Population Study
Association of Air Pollution with a Urinary Biomarker of Biological Aging and Effect Modification by Vitamin K in the FLEMENGHO Prospective Population Study Open
Ambient air pollution was associated with accelerated urinary peptidomics aging, and high vitamin K status showed a potential protective effect in this population. Current guidelines are insufficient to decrease the adverse health effects …
View article: Blood pressure and renal function responses in workers exposed to lead for up to six years
Blood pressure and renal function responses in workers exposed to lead for up to six years Open
The Study for Promotion of Health in Recycling Lead (SPHERL) assessed the blood pressure (BP) and renal function (RF) responses for up to 6 years in the workers without previous occupational lead exposure. BP was the average of five consec…
View article: Urinary peptides provide information about the risk of mortality across a spectrum of diseases and scenarios
Urinary peptides provide information about the risk of mortality across a spectrum of diseases and scenarios Open
Background There is evidence of pre-established vulnerability in individuals that increases the risk of their progression to severe disease or death, although the mechanisms causing this are still not fully understood. Previous research ha…
View article: Blood pressure and hypertension in relation to lead exposure updated according to present-day blood lead levels
Blood pressure and hypertension in relation to lead exposure updated according to present-day blood lead levels Open
Lead is an environmental hazard that should be addressed worldwide. Over time, human exposure to lead in the Western world has fallen drastically to the levels comparable to those in humans living in the pre-industrial era, who were mainly…
View article: Derivation of an Outcome-Driven Threshold for Aortic Pulse Wave Velocity: An Individual-Participant Meta-Analysis
Derivation of an Outcome-Driven Threshold for Aortic Pulse Wave Velocity: An Individual-Participant Meta-Analysis Open
BACKGROUND: Aortic pulse wave velocity (PWV) predicts cardiovascular events (CVEs) and total mortality (TM), but previous studies proposing actionable PWV thresholds have limited generalizability. This individual-participant meta-analysis …
View article: Derivation of an Outcome-Driven Threshold for Aortic Pulse Wave Velocity: An Individual-Participant Meta-Analysis
Derivation of an Outcome-Driven Threshold for Aortic Pulse Wave Velocity: An Individual-Participant Meta-Analysis Open
BACKGROUND Aortic pulse wave velocity (PWV) predicts cardiovascular events (CVE) and total mortality (TM), but previous studies proposing actionable PWV thresholds have limited generalizability. This individual-participant meta-analysis is…
View article: Urinary proteomics combined with home blood pressure telemonitoring for health care reform trial—First progress report
Urinary proteomics combined with home blood pressure telemonitoring for health care reform trial—First progress report Open
High blood pressure (BP) and type‐2 diabetes (T2DM) are forerunners of chronic kidney disease and left ventricular dysfunction. Home BP telemonitoring (HTM) and urinary peptidomic profiling (UPP) are technologies enabling risk stratificati…