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View article: Ginkgolic Acid Derivatives from Ginkgo biloba Show Inhibitory Activity against Protein Tyrosine Phosphatases Associated with Insulin Resistance
Ginkgolic Acid Derivatives from Ginkgo biloba Show Inhibitory Activity against Protein Tyrosine Phosphatases Associated with Insulin Resistance Open
Ginkgo biloba L. (Ginkgoacea) contains an abundance of beneficial compounds and has demonstrated positive clinical effects in the management of metabolic syndrome. Recent studies have emphasized its efficacy against type 2 diabetes mellitu…
View article: Identification of Crocetin as a Dual Agonist of GPR40 and GPR120 Responsible for the Antidiabetic Effect of Saffron
Identification of Crocetin as a Dual Agonist of GPR40 and GPR120 Responsible for the Antidiabetic Effect of Saffron Open
Crocin, a glycoside of crocetin, has been known as the principal component responsible for saffron’s antidiabetic, anticancer, and anti-inflammatory effects. Crocetin, originating from the hydrolytic cleavage of crocin in biological system…
View article: Methyl Syringate Stimulates Glucose Uptake by Inhibiting Protein Tyrosine Phosphatases Relevant to Insulin Resistance
Methyl Syringate Stimulates Glucose Uptake by Inhibiting Protein Tyrosine Phosphatases Relevant to Insulin Resistance Open
Several protein tyrosine phosphatases (PTPs), particularly PTPN1, PTPN2, PTPN6, PTPN9, PTPN11, PTPRS, and DUSP9, are involved in insulin resistance. Therefore, these PTPs could be promising targets for the treatment of type 2 diabetes. Our…
View article: Effects of CCN6 overexpression on the cell motility and activation of p38/bone morphogenetic protein signaling pathways in pancreatic cancer cells
Effects of CCN6 overexpression on the cell motility and activation of p38/bone morphogenetic protein signaling pathways in pancreatic cancer cells Open
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancer types that is highly resistant to conventional treatments, such as chemotherapy and radiotherapy. As the demand for more effective therapeutics for PDAC treatment…
View article: Ethyl Gallate Dual-Targeting PTPN6 and PPARγ Shows Anti-Diabetic and Anti-Obese Effects
Ethyl Gallate Dual-Targeting PTPN6 and PPARγ Shows Anti-Diabetic and Anti-Obese Effects Open
The emergence of the high correlation between type 2 diabetes and obesity with complicated conditions has led to the coinage of the term “diabesity”. AMP-activated protein kinase (AMPK) activators and peroxisome proliferator-activated rece…
View article: Structure–Activity Relationship of Synthetic Ginkgolic Acid Analogs for Treating Type 2 Diabetes by PTPN9 Inhibition
Structure–Activity Relationship of Synthetic Ginkgolic Acid Analogs for Treating Type 2 Diabetes by PTPN9 Inhibition Open
Ginkgolic acid (C13:0) (GA), isolated from Ginkgo biloba, is a potential therapeutic agent for type 2 diabetes. A series of GA analogs were designed and synthesized for the evaluation of their structure–activity relationship with respect t…
View article: Chebulinic Acid Suppresses Adipogenesis in 3T3-L1 Preadipocytes by Inhibiting PPP1CB Activity
Chebulinic Acid Suppresses Adipogenesis in 3T3-L1 Preadipocytes by Inhibiting PPP1CB Activity Open
Depletion of protein phosphatase-1 catalytic subunit beta (PPP1CB), a serine/threonine protein phosphatase and potent adipogenic activator, suppresses the differentiation of 3T3-L1 preadipocytes into mature adipocytes. Therefore, PPP1CB is…
View article: Polyphyllin D Shows Anticancer Effect through a Selective Inhibition of Src Homology Region 2-Containing Protein Tyrosine Phosphatase-2 (SHP2)
Polyphyllin D Shows Anticancer Effect through a Selective Inhibition of Src Homology Region 2-Containing Protein Tyrosine Phosphatase-2 (SHP2) Open
Natural products have continued to offer tremendous opportunities for drug development, as they have long been used in traditional medicinal systems. SHP2 has served as an anticancer target. To identify novel SHP2 inhibitors with potential…
View article: Enzyme Mimetic Activity of ZnO-Pd Nanosheets Synthesized via a Green Route
Enzyme Mimetic Activity of ZnO-Pd Nanosheets Synthesized via a Green Route Open
Recent developments in the area of nanotechnology have focused on the development of nanomaterials with catalytic activities. The enzyme mimics, nanozymes, work efficiently in extreme pH and temperature conditions, and exhibit resistance t…
View article: Facile Synthesis of Triangular and Hexagonal Anionic Gold Nanoparticles and Evaluation of Their Cytotoxicity
Facile Synthesis of Triangular and Hexagonal Anionic Gold Nanoparticles and Evaluation of Their Cytotoxicity Open
Comprehension of the shape-dependent properties of gold nanoparticles (AuNPs) could benefit the advancements in cellular uptake efficiency. Spherical AuNPs have generally been used for drug delivery, and recent research has indicated that …
View article: High‐Intensity Interval Training for Patients With Cardiovascular Disease—Is It Safe? A Systematic Review
High‐Intensity Interval Training for Patients With Cardiovascular Disease—Is It Safe? A Systematic Review Open
Background Cardiac rehabilitation ( CR ) for patients with cardiovascular disease has traditionally involved low‐ to moderate‐intensity continuous aerobic exercise training ( MICT ). There is growing and robust evidence that high‐intensity…
View article: A Basic Study on Capture and Solidification of Rare Earth Nuclide (Nd) in LiCl-KCl Eutectic Salt Using an Inorganic Composite With Li2O-Al2O3-SiO2-B2O3 System
A Basic Study on Capture and Solidification of Rare Earth Nuclide (Nd) in LiCl-KCl Eutectic Salt Using an Inorganic Composite With Li2O-Al2O3-SiO2-B2O3 System Open
사용후핵연료 파이로프로세싱에서는 방사성 희토류 염화물(RECl3)을 함유한 LiCl-KCl 공융염폐기물이 발생되며, 핫셀시설 에서 운영을 목적으로 단순한 형태의 공융염폐기물 처리공정을 개발하는 것이 필요하다. 본 연구에서는, LiCl-KCl 공융염폐 기물 내 희토류 핵종 분리/고화공정의 단순화를 목적으로 Li2O-Al2O3-SiO2-B2O3계의 무기합성매질을 이용하여 LiCl-KCl 공융 염 내 희토류 핵종(Nd)을 분리한 …
View article: Engineering Design of a Voloxidizer with a Double Reactor for the Hull Separation of Spent Nuclear Fuel Rods
Engineering Design of a Voloxidizer with a Double Reactor for the Hull Separation of Spent Nuclear Fuel Rods Open
A voloxidizer with a double reactor capable of processing several tens of kilograms of HM/batch of nuclear spent fuel has been developed for the decladding and voloxidation of rod-cuts into hulls and pellets through the conversion of UO 2 …
View article: Effect of Cold Drawing and Heat Treatment on the Microstructure of Invar36 Alloy Wire
Effect of Cold Drawing and Heat Treatment on the Microstructure of Invar36 Alloy Wire Open
In this study, the effect of cold drawing and heat treatment on the microstructure of Invar36 alloy wire was investigated.Invar36 alloy wire is used as a transmission line core material, and is required to have high strength.The diameter o…
View article: Addition Effect of Fluoride Compounds for Zr Electrorefining in LiCl-KCl Molten Salts
Addition Effect of Fluoride Compounds for Zr Electrorefining in LiCl-KCl Molten Salts Open
The effect of fluoride compounds on Zr electrorefining is investigated for Zirlo cladding tubes in LiCl- KCl based molten salts. Cyclic voltammetric curves exhibit a modification of electrochemical behaviors of Zr ions from a two-step redu…
View article: Study on the Vibrational Scraping of Uranium Product from a Solid Cathode of Electrorefiner
Study on the Vibrational Scraping of Uranium Product from a Solid Cathode of Electrorefiner Open
A high-throughput electrorefiner has been developed for commercialization use by enhancing the uranium recovery from the reduced metal which is produced from the oxide reduction process. It is necessary to scrap and effectively collect ura…
View article: Effect of Rare Earth Elements on Uranium Electrodeposition in LiCl-KCl Eutectic Salt
Effect of Rare Earth Elements on Uranium Electrodeposition in LiCl-KCl Eutectic Salt Open
It is necessary to investigate the electrodeposition behavior of uranium and other elements on the cathode in the electrorefining process to recover the uranium selectively from the reduced metals of the electrolytic reduction process sinc…
View article: A Study on the Separation and Solidification of Group II Nuclides from LiCl Waste Salt Generated from a Pyrochemical Process
A Study on the Separation and Solidification of Group II Nuclides from LiCl Waste Salt Generated from a Pyrochemical Process Open
Waste treatment technology for the separation and solidification of radioactive nuclides generated from the pyrochemical process has been intensively studied to achieve the reduction of radioactive waste volume. The present study reports t…
View article: The Effects of Cross-Section Openings on the Chlorination Reaction Rate of ZIRLO Cladding Hulls
The Effects of Cross-Section Openings on the Chlorination Reaction Rate of ZIRLO Cladding Hulls Open
The reaction rates of ZIRLO cladding hulls with cross-section openings were investigated using a thermo-gravimetric analysis system in order to identify whether selective recovery of Zr from oxidized cladding hulls is possible. The experim…
View article: Separation Characteristics of NdCl3 from LiCl-KCl Eutectic Salt in a Reactive Distillation Process using Li2CO3 or K2CO3
Separation Characteristics of NdCl3 from LiCl-KCl Eutectic Salt in a Reactive Distillation Process using Li2CO3 or K2CO3 Open
It is necessary to develop an effective waste salt treatment technology for the minimization of radioactive waste generation from the pyroprocessing of spent nuclear fuel. For this reason, the separation characteristics of NdCl3 from LiCl-…
View article: A Preliminary Study on the Feasibility of Copper Mesh as an Off-Gas Iodine Capturing Medium for Pyroprocessing
A Preliminary Study on the Feasibility of Copper Mesh as an Off-Gas Iodine Capturing Medium for Pyroprocessing Open
A commercially available copper mesh was investigated as an iodine off-gas capturing medium for pyroprocessing, with an aim to replace costly silver based adsorbents. Theoretical calculation results suggested that the reaction between meta…
View article: Fabrication of UO<sub>2</sub>Porous Pellets on a Scale of 30 kg-U/Batch at the PRIDE Facility
Fabrication of UO<sub>2</sub>Porous Pellets on a Scale of 30 kg-U/Batch at the PRIDE Facility Open
In the pyroprocess integrated inactive demonstration (PRIDE) facility at the Korea Atomic Energy Research Institute (KAERI), UO 2 porous pellets were fabricated as a feed material for electrolytic reduction on an engineering scale of 30 kg…