Doaa A. Radwan
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View article: Plastinated Specimens versus Plastic Models of the Upper Limb: Performance, Outcomes, and Preferences in Anatomy Education
Plastinated Specimens versus Plastic Models of the Upper Limb: Performance, Outcomes, and Preferences in Anatomy Education Open
Background: Traditional cadaveric dissection is central to anatomy education, but presents ethical, logistical, and practical challenges. This study explores alternative teaching modalities by comparing plastinated specimens (PSs) and plas…
View article: Adropin/Tirzepatide Combination Mitigates Cardiac Metabolic Aberrations in a Rat Model of Polycystic Ovarian Syndrome, Implicating the Role of the AKT/GSK3β/NF-κB/NLRP3 Pathway
Adropin/Tirzepatide Combination Mitigates Cardiac Metabolic Aberrations in a Rat Model of Polycystic Ovarian Syndrome, Implicating the Role of the AKT/GSK3β/NF-κB/NLRP3 Pathway Open
Polycystic ovarian syndrome (PCOS) is a multifaceted metabolic and hormonal disorder in females of reproductive age, frequently associated with cardiac disturbances. This research aimed to explore the protective potential of adropin and/or…
View article: Empagliflozin Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Rats by Modulating Sesn2/AMPK/Nrf2 Signaling and Targeting Ferroptosis and Autophagy
Empagliflozin Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Rats by Modulating Sesn2/AMPK/Nrf2 Signaling and Targeting Ferroptosis and Autophagy Open
Pulmonary fibrosis (PF) is a life-threatening disorder that severely disrupts normal lung architecture and function, resulting in severe respiratory failure and death. It has no definite treatment. Empagliflozin (EMPA), a sodium-glucose co…
View article: Adrenomedullin Mitigates Doxorubicin-Induced Nephrotoxicity in Rats: Role of Oxidative Stress, Inflammation, Apoptosis, and Pyroptosis
Adrenomedullin Mitigates Doxorubicin-Induced Nephrotoxicity in Rats: Role of Oxidative Stress, Inflammation, Apoptosis, and Pyroptosis Open
Doxorubicin (DOX) is an anticancer antibiotic which has various effects in human cancers. It is one of the commonly known causes of drug-induced nephrotoxicity, which results in acute renal injury. Adrenomedullin (ADM), a vasodilator pepti…
View article: Irisin improves adiposity and exercise tolerance in a rat model of postmenopausal obesity through enhancing adipo-myocyte thermogenesis
Irisin improves adiposity and exercise tolerance in a rat model of postmenopausal obesity through enhancing adipo-myocyte thermogenesis Open
The prevalence of obesity and its associated metabolic disorders, along with their healthcare costs, is rising exponentially. Irisin, an adipomyokine, may serve as a critical cross-organ messenger, linking skeletal muscle with adipose tiss…
View article: Diffusion Weighted (DW) MRI in Correlation with Dynamic Contrast Enhanced MRI for Characterization of Ovarian Masses
Diffusion Weighted (DW) MRI in Correlation with Dynamic Contrast Enhanced MRI for Characterization of Ovarian Masses Open
Background: Ovarian tumors; are the second most common gynecological tumor and in women are the fifth commonest tumor. Preoperative differentiation between benign and malignant tumors is essential to decide whether surgery is required, and…
View article: Melatonin epigenetic potential on testicular functions and fertility profile in varicocele rat model is mediated by silent information regulator 1
Melatonin epigenetic potential on testicular functions and fertility profile in varicocele rat model is mediated by silent information regulator 1 Open
Background and Purpose Varicocele is a leading cause of male infertility. Melatonin is a highly pleiotropic neurohormone. We aimed to characterize the melatonin epigenetic potential in varicocele and the involved molecular mechanisms. Expe…
View article: Antioxidant Approach of Nigella Sativa, Vit C and Silymarin for amelioration of Azithromycin induced Hepatotoxicity: Histological, Immunohistochemical and Biochemical study
Antioxidant Approach of Nigella Sativa, Vit C and Silymarin for amelioration of Azithromycin induced Hepatotoxicity: Histological, Immunohistochemical and Biochemical study Open
Background: Azithromycin (AZ) is a broad-spectrum antibiotic however AZ hepatotoxicity limits its therapeutic indications.The aim of this work was to clarify the hepatotoxicity of AZ on albino rat and the possible protective effect of anti…
View article: The impact of oral ciprofloxacin on the structure and functions of rat gastric mucosa
The impact of oral ciprofloxacin on the structure and functions of rat gastric mucosa Open
Ciprofloxacin (CPX), is a fluoroquinolone antibiotic used to treat a number of gram-negative and gram-positive bacterial infections. Ciprofloxacin can cause severe side effects, ranging from tendon problems, nerve damage, to serious mood o…