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View article: Upregulation of the neuropeptide receptor calcitonin receptor-like in the spinal cord via MLL2 in a mouse model of paclitaxel-induced peripheral neuropathy
Upregulation of the neuropeptide receptor calcitonin receptor-like in the spinal cord via MLL2 in a mouse model of paclitaxel-induced peripheral neuropathy Open
Chemotherapy-induced peripheral neuropathy (CIPN) is a prevalent and severe side effect affecting cancer patients undergoing paclitaxel treatment. Growing evidence underscores the pivotal role of calcitonin-related peptide (CGRP) in the de…
View article: Baseline Chromatin Modification Levels May Predict Interindividual Variability in Ozone-Induced Gene Expression
Baseline Chromatin Modification Levels May Predict Interindividual Variability in Ozone-Induced Gene Expression Open
Traditional toxicological paradigms have relied on factors such as age, genotype, and disease status to explain variability in responsiveness to toxicant exposure; however, these are neither sufficient to faithfully identify differentially…
View article: Epigenetic alterations at synaptic plasticity genes in a genetically heterogeneous rat model of neuropsychiatric disorders
Epigenetic alterations at synaptic plasticity genes in a genetically heterogeneous rat model of neuropsychiatric disorders Open
Sensorimotor gating impairments are observed across a range of neuropsychiatric conditions. The prepulse inhibition of the acoustic startle response (PPI) is a validated measure of sensorimotor gating. Genetic and pharmacological manipulat…
View article: Metabotropic Glutamate Receptor 2 and Dopamine Receptor 2 Gene Expression Predict Sensorimotor Gating Response in the Genetically Heterogeneous NIH-HS Rat Strain
Metabotropic Glutamate Receptor 2 and Dopamine Receptor 2 Gene Expression Predict Sensorimotor Gating Response in the Genetically Heterogeneous NIH-HS Rat Strain Open
View article: Role of mGlu2 in the 5-HT2A receptor-dependent antipsychotic activity of clozapine in mice
Role of mGlu2 in the 5-HT2A receptor-dependent antipsychotic activity of clozapine in mice Open
View article: Using Chromatin Immunoprecipitation in Toxicology: A Step‐by‐Step Guide to Increasing Efficiency, Reducing Variability, and Expanding Applications
Using Chromatin Immunoprecipitation in Toxicology: A Step‐by‐Step Guide to Increasing Efficiency, Reducing Variability, and Expanding Applications Open
Histone modifications work in concert with DNA methylation to regulate cellular structure, function, and response to environmental stimuli. More than 130 unique histone modifications have been described to date, and chromatin immunoprecipi…
View article: Baseline Chromatin Modification Levels May Predict Interindividual Variability in Ozone-Induced Gene Expression
Baseline Chromatin Modification Levels May Predict Interindividual Variability in Ozone-Induced Gene Expression Open
Traditional toxicological paradigms have relied on factors such as age, genotype, and disease status to explain variability in responsiveness to toxicant exposure; however, these are neither sufficient to faithfully identify differentially…