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View article: Urolithin A Abolishes High Anxiety and Rescues the Associated Mitochondria-Related Transcriptomic Signatures and Synaptic Function
Urolithin A Abolishes High Anxiety and Rescues the Associated Mitochondria-Related Transcriptomic Signatures and Synaptic Function Open
These findings position UA as a mechanistically supported intervention in preclinical models of heightened anxiety and provide systems-level insights into how mitochondrial pathways interface with synaptic function and circuit regulation i…
View article: Mitochondrial control of ciliary gene expression and structure in striatal neurons
Mitochondrial control of ciliary gene expression and structure in striatal neurons Open
Mitochondria play essential metabolic roles and are increasingly understood to interact with other organelles, influencing cellular function and disease. Primary cilia, as sensory and signalling organelles, are crucial for neuronal communi…
View article: Adolescent Stress-Induced Ventral Hippocampus Redox Dysregulation Underlies Behavioral Deficits and Excitatory/Inhibitory Imbalance Related to Schizophrenia
Adolescent Stress-Induced Ventral Hippocampus Redox Dysregulation Underlies Behavioral Deficits and Excitatory/Inhibitory Imbalance Related to Schizophrenia Open
Background and Hypothesis Redox dysregulation has been proposed as a convergent point of childhood trauma and the emergence of psychiatric disorders, such as schizophrenia (SCZ). A critical region particularly vulnerable to environmental i…
View article: Adolescent stress-induced behavioral deficits, ventral hippocampus redox dysregulation and excitatory/inhibitory imbalance related to schizophrenia
Adolescent stress-induced behavioral deficits, ventral hippocampus redox dysregulation and excitatory/inhibitory imbalance related to schizophrenia Open
Redox dysregulation has been proposed as a convergent point of childhood trauma and the emergence of psychiatric disorders, such as schizophrenia (SCZ). However, the impact of severe stressors during adolescence on the ventral hippocampus …
View article: Transcriptomic analysis reveals mitochondrial pathways associated with distinct adolescent behavioral phenotypes and stress response
Transcriptomic analysis reveals mitochondrial pathways associated with distinct adolescent behavioral phenotypes and stress response Open
View article: Powering the social brain: Mitochondria in social behaviour
Powering the social brain: Mitochondria in social behaviour Open
A central role of brain mitochondria in regulating and influencing social behaviour is emerging. In addition to its important roles as the "powerhouses" of the cell, mitochondria possess a plethora of cellular functions, such as regulating…
View article: Butyrate mediated regulation of RNA binding proteins in the post-transcriptional regulation of inflammatory gene expression
Butyrate mediated regulation of RNA binding proteins in the post-transcriptional regulation of inflammatory gene expression Open