Explanipedia

CPT1C deficiency in SF1 neurons impairs early metabolic adaptation to dietary fats, leading to obesity Open

Anna Fosch, D Pizarro, Sebastián Zagmutt, Ana Cristina Reguera, Gerard Batallé , et al. · 2025

New UB006 Derivatives With Higher Solubility and Cytotoxic Activity in Ovarian Cancer Cells Open

Manuel Reina, Xavier Ariza, Dolors Serra, Jordi García, Laura Herrero · 2025

Background/Objectives: The compound (±)-UB006 ((4SR,5SR)-4-(hydroxymethyl)-3-methylene-5-octyldihydrofuran-2(3H)-one) is a promising anti-cancer molecule. The enantiomer (–)-UB006 displays a potent cytotoxic effect in several tumor cell li…

The dual GLP-1/glucagon receptor agonist G49 mimics bariatric surgery effects by inducing metabolic rewiring and inter-organ crosstalk Open

M. Pilar Valdecantos, Laura Ruíz-Cañas, Cintia Folgueira, Patricia Rada, Beatriz Gómez‐Santos , et al. · 2024

Bariatric surgery is effective for the treatment and remission of obesity and type 2 diabetes, but pharmacological approaches which exert similar metabolic adaptations are needed to avoid post-surgical complications. Here we show how G49, …

DEFICIENCY OF THE NUTRIENT SENSOR CPT1c IN SF1 NEURONS DISRUPTS THE ENDOCANNABINOID SYSTEM RESULTING IN COMPROMISED SATIETY AND FUEL SELECTION UPON FAT INTAKE Open

Anna Fosch, D Pizarro, Sebastián Zagmutt, Ana Cristina Reguera, Gerard Batallé , et al. · 2024

The SF1 neurons of the ventromedial hypothalamus (VMH) are pivotal in governing body weight and adiposity, particularly in response to a high-fat diet (HFD). Previous studies have shown that the activation of SF1 neurons induces satiety, i…

Cpt1a silencing in AgRP neurons improves cognitive and physical capacity and promotes healthy aging in male mice Open

Kevin Ibeas, Christian Griñán‐Ferré, María del Mar Romero, David Sebastián, Marianela Bastías‐Pérez , et al. · 2023

Orexigenic neurons expressing agouti‐related protein (AgRP) and neuropeptide Y in the arcuate nucleus (ARC) of the hypothalamus are activated in response to dynamic variations in the metabolic state, including exercise. We previously obser…

Inhibition of YTHDF1 by salvianolic acid overcomes gluten-induced intestinal inflammation Open

Ane Olazagoitia‐Garmendia, Henar Rojas‐Márquez, María del Mar Romero, Pamela Ruiz, Aloña Agirre‐Lizaso , et al. · 2023

Adipose Tissue Dynamics: Cellular and Lipid Turnover in Health and Disease Open

Ivonne Palacios‐Marin, Dolors Serra, Josep C. Jiménez‐Chillarón, Laura Herrero, Marijana Todorčević · 2023

The alarming increase in obesity and its related metabolic health complications, such as type 2 diabetes, has evolved into a global pandemic. Obesity is mainly characterized by excessive accumulation of adipose tissue, primarily due to an …

Childhood obesity: Implications on adipose tissue dynamics and metabolic health Open

Ivonne Palacios‐Marin, Dolors Serra, Josep C. Jiménez‐Chillarón, Laura Herrero, Marijana Todorčević · 2023

Summary Obesity is the leading risk factor for the development of type 2 diabetes and cardiovascular diseases. Childhood obesity represents an alarming health challenge because children with obesity are prone to remain with obesity through…

Implantation of CPT1AM-expressing adipocytes reduces obesity and glucose intolerance in mice Open

M. Carmen Soler‐Vázquez, María del Mar Romero, Marijana Todorčević, Katia Delgado, Carles Calatayud , et al. · 2023

3D bioprinted functional skeletal muscle models have potential applications for studies of muscle wasting in cancer cachexia Open

Andrea García‐Lizarribar, Aránzazu Villasante, José A. López-Martín, Marta Flández, M. Carmen Soler‐Vázquez , et al. · 2023

Acquired muscle diseases such as cancer cachexia are responsible for the poor prognosis of many patients suffering from cancer. In vitro models are needed to study the underlying mechanisms of those pathologies. Extrusion bioprinting is an…

CPT1A in AgRP neurons is required for sex-dependent regulation of feeding and thirst Open

Sebastián Zagmutt, Paula Mera, Ismael González‐García, Kevin Ibeas, María del Mar Romero , et al. · 2023

To be or not to be a fat burner, that is the question for cpt1c in cancer cells Open

Rut Fadó, Sebastián Zagmutt, Laura Herrero, Helena Muley, Rosalía Rodríguez‐Rodríguez , et al. · 2023

There is an urgent need to identify reliable genetic biomarkers for accurate diagnosis, prognosis, and treatment of different tumor types. Described as a prognostic marker for many tumors is the neuronal protein carnitine palmitoyltransfer…

Central Regulation of Brown Fat Thermogenesis in Response to Saturated or Unsaturated Long-Chain Fatty Acids Open

Anna Fosch, María Rodriguez-Garcia, Cristina Miralpeix, Sebastián Zagmutt, Maite Larrañaga , et al. · 2023

Sensing of long-chain fatty acids (LCFA) in the hypothalamus modulates energy balance, and its disruption leads to obesity. To date, the effects of saturated or unsaturated LCFA on hypothalamic-brown adipose tissue (BAT) axis and the under…

Hydrolat of Helichrysum Italicum promotes tissue regeneration during wound healing Open

Dolors Serra, Emanuela Bellu, Giuseppe Garroni, Sara Cruciani, Giorgia Sarais , et al. · 2023

Wound healing is a dynamic process involving different cell types with distinct roles according to the stages of healing. Fibroblasts and stem cells actively participate in tissue regeneration. A proper stimulation could contribute to enha…

Nanomedicine targeting brain lipid metabolism as a feasible approach for controlling the energy balance Open

Jesús García-Chica, West Kristian D. Paraiso, Sebastián Zagmutt, Anna Fosch, Ana Cristina Reguera , et al. · 2023

Targeting brain lipid metabolism using polymeric-based nanomedicine is a promising strategy to regulate the energy balance and fight metabolic diseases such as obesity.

A next generation therapy to treat obesity throughthe brain Open

Zagmutt Sebastian, Jesús García-Chica, West Kristian D., Paraiso Anna Fosch, Ana Cristina Reguera , et al. · 2023

Obesity has become an important health problem and its prevalence is highlyincreasing. Pharmacotherapy alone or in combination with either lifestylemodification or surgery, is consistent in maintaining a healthy body weight, andpreventing …

Role of long non-coding RNAs in adipose tissue metabolism and associated pathologies Open

Ana Corral, Martín Alcalá, Ma Carmen Durán-Ruiz, Ana I. Arroba, Jesús Gustavo Ponce‐González , et al. · 2022

Ptpn1 deletion protects oval cells against lipoapoptosis by favoring lipid droplet formation and dynamics Open

Inés Barahona, Patricia Rada, Silvia Calero‐Pérez, Rubén Grillo-Risco, Laura Pereira , et al. · 2022

Inhibition of carnitine palmitoyltransferase 1A in hepatic stellate cells protects against fibrosis Open

Marcos F. Fondevila, Uxia Fernandez, Violeta Heras, Tamara Parracho, María J. Gonzalez-Rellan , et al. · 2022

We show that the enzyme carnitine palmitoyltransferase 1A (CPT1A) is elevated in hepatic stellate cells (HSCs) in patients with fibrosis and mouse models of fibrosis, and that CPT1A induces the activation of these cells. Inhibition of CPT1…

3D Bioprinted Functional Skeletal Muscle Models Have Potential Applications for Studies of Cancer Cachexia Open

Andrea García‐Lizarribar, Aránzazu Villasante, José A. López-Martín, Marta Flández, M. Carmen Soler‐Vázquez , et al. · 2022

Hemobilia y hemocolecisto agudo como forma de presentación inusual del cáncer de vesícula biliar Open

José Jacob Motos-Micó, Javier Cortés-Climent, Lirios Ferri-Candela, Francisco Arlandis-Félix, Dolors Serra · 2021

Gallbladder cancer that presents as acute cholecystitis associated with hemocholecyst and hemobilia is a rare entity. There are few cases reported in the literature. We present a case of gallbladder carcinoma diagnosed after emergency chol…

Inhibition of ATG3 ameliorates liver steatosis by increasing mitochondrial function Open

Natália da Silva Lima, Marcos F. Fondevila, Eva Nóvoa, Xabier Buqué, María Mercado-Gómez , et al. · 2021

We show that autophagy-related gene 3 (ATG3) contributes to the progression of non-alcoholic fatty liver disease in humans and mice. Hepatic knockdown of ATG3 ameliorates the development of NAFLD by stimulating mitochondrial function. Thus…

White adipose tissue dysfunction in obesity and aging Open

Marjorie Reyes‐Farias, Júlia Fos-Domènech, Dolors Serra, Laura Herrero, David Sánchez‐Infantes · 2021

Both obesity and aging are associated with the development of metabolic diseases such as type 2 diabetes and cardiovascular disease. Chronic low-grade inflammation of adipose tissue is one of the mechanisms implicated in the progression of…

Infusion of Phagocytic Macrophages Overexpressing CPT1a Ameliorates Kidney Fibrosis in the UUO Model Open

Priscila Calle, Soraya Játiva, Selene Torrico, Ángeles Muñoz, Miriam García , et al. · 2021

Phagocytosis is an inherent function of tissue macrophages for the removal of apoptotic cells and cellular debris during acute and chronic injury; however, the dynamics of this event during fibrosis development is unknown. We aim to prove …

Inhibition of fatty acid synthesis induces differentiation and reduces tumor burden in childhood neuroblastoma Open

María Victoria Ruiz-Pérez, Lourdes Sainero‐Alcolado, Ganna Oliynyk, Isabell Matuschek, Nicola Balboni , et al. · 2021

Gluten-induced RNA methylation changes regulate intestinal inflammation via allele-specific XPO1 translation in epithelial cells Open

Ane Olazagoitia‐Garmendia, Linda Zhang, Paula Mera, J Godbout, Maialen Sebastian‐delaCruz , et al. · 2021

Objectives Coeliac disease (CD) is a complex autoimmune disorder that develops in genetically susceptible individuals. Dietary gluten triggers an immune response for which the only available treatment so far is a strict, lifelong gluten fr…

Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasis Open

Verónica Miguel, Jessica Tituaña, J. Ignacio Herrero, Laura Herrero, Dolors Serra , et al. · 2021

Chronic kidney disease (CKD) remains a major epidemiological, clinical, and biomedical challenge. During CKD, renal tubular epithelial cells (TECs) present a persistent inﬂammatory and profibrotic response. Fatty acid oxidation (FAO), the …

Dietary Options for Rodents in the Study of Obesity Open

Marianela Bastías‐Pérez, Dolors Serra, Laura Herrero · 2020

Obesity and its associated metabolic diseases are currently a priority research area. The increase in global prevalence at different ages is having an enormous economic and health impact. Genetic and environmental factors play a crucial ro…

Moderate SIRT1 overexpression protects against brown adipose tissue inflammation Open

Carmen Escalona-Garrido, Patricia Vázquez, Paula Mera, Sebastián Zagmutt, Ester García-Casarrubios , et al. · 2020

This study has ascertained the benefit of the moderate overexpression of SIRT1 to confer protection against defective insulin and β-adrenergic responses caused by BAT inflammation. Our results have potential therapeutic value in combinator…

Effects of High-Fat Diet and Maternal Binge-Like Alcohol Consumption and Their Influence on Cocaine Response in Female Mice Offspring Open

Leticia Duart-Castells, Lídia Cantacorps, Raúl López‐Arnau, Sandra Montagud‐Romero, Brigitte Puster , et al. · 2020

Background Prenatal alcohol exposure is a leading cause of neurobehavioral and neurocognitive deficits collectively known as fetal alcohol spectrum disorders, including eating disorders and increased risk for substance abuse as very common…

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