Domenic Di Stefano
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View article: Alfaxalone is an effective anesthetic for the electrophysiological study of anoxia-tolerance mechanisms in western painted turtle pyramidal neurons
Alfaxalone is an effective anesthetic for the electrophysiological study of anoxia-tolerance mechanisms in western painted turtle pyramidal neurons Open
Anoxia in the mammalian brain leads to hyper-excitability and cell death; however, this cascade of events does not occur in the anoxia-tolerant brain of the western painted turtle, Chrysemys picta belli . The painted turtle has become an i…
View article: Alfaxalone does not have long‐term effects on goldfish pyramidal neuron action potential properties or <scp> GABA <sub>A</sub> </scp> receptor currents
Alfaxalone does not have long‐term effects on goldfish pyramidal neuron action potential properties or <span> GABA <sub>A</sub> </span> receptor currents Open
Anesthetics have varying physiological effects, but most notably alter ion channel kinetics. Alfaxalone is a rapid induction and washout neuroactive anesthetic, which potentiates γ‐aminobutyric acid (GABA)‐activated GABA A receptor (GABA A…
View article: Alfaxalone is an Effective Anesthetic for the Electrophysiological Study of Anoxia-Tolerance Mechanisms in Western Painted Turtle Pyramidal Neurons v1
Alfaxalone is an Effective Anesthetic for the Electrophysiological Study of Anoxia-Tolerance Mechanisms in Western Painted Turtle Pyramidal Neurons v1 Open
Many anesthetics have long-term effects on ion channels and are not appropriate for same day experimentation. Using whole-cell electrophysiological techniques, we examine the effects of the anesthetic, Alfaxalone, on pyramidal cell action …