Domenic Ebert
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View article: Structural and functional analysis of natural capsid variants suggests sialic acid-independent entry of BK polyomavirus
Structural and functional analysis of natural capsid variants suggests sialic acid-independent entry of BK polyomavirus Open
BK polyomavirus (BKPyV) is an opportunistic pathogen that uses the b-series gangliosides GD1b and GT1b as entry receptors. Here, we characterize the impact of naturally occurring VP1 mutations on ganglioside binding, VP1 protein structure,…
View article: Structural and functional analysis of natural capsid variants reveals sialic-acid independent entry of BK polyomavirus
Structural and functional analysis of natural capsid variants reveals sialic-acid independent entry of BK polyomavirus Open
BK Polyomavirus (BKPyV) is an opportunistic pathogen that causes nephropathy in kidney transplant recipients. The BKPyV major capsid protein, VP1, engages gangliosides, lipid-linked sialylated glycans at the cell surface, to gain entry int…