Domenica Donatella Li Puma
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View article: Intranasal delivery of extracellular vesicles derived from human bone marrow mesenchymal stem cells dampens neuroinflammation and ameliorates motor deficits in a mouse model of cortical stroke
Intranasal delivery of extracellular vesicles derived from human bone marrow mesenchymal stem cells dampens neuroinflammation and ameliorates motor deficits in a mouse model of cortical stroke Open
Early treatment of ischemic stroke can significantly reduce disability and mortality rates. Stem cell-derived extracellular vesicles (EVs) have shown potential as therapeutics for neurological disorders. This study explored whether intrana…
View article: Lithium‐Charged Gold Nanoparticles: A New Powerful Tool for Lithium Delivery and Modulation of Glycogen Synthase Kinase 3 Activity
Lithium‐Charged Gold Nanoparticles: A New Powerful Tool for Lithium Delivery and Modulation of Glycogen Synthase Kinase 3 Activity Open
“A Trojan Horse for Lithium Delivery” . Lithium has important pharmacological applications, although its use is severely limited due to its narrow therapeutic window of administrable concentrations. This study presents a novel nanocarrier …
View article: Structural and functional alterations of neurons derived from sporadic Alzheimer’s disease hiPSCs are associated with downregulation of the LIMK1-cofilin axis
Structural and functional alterations of neurons derived from sporadic Alzheimer’s disease hiPSCs are associated with downregulation of the LIMK1-cofilin axis Open
View article: Blockade of dopamine <scp>D3</scp> receptors improves hippocampal synaptic function and rescues age‐related cognitive phenotype
Blockade of dopamine <span>D3</span> receptors improves hippocampal synaptic function and rescues age‐related cognitive phenotype Open
Dopamine D3 receptors (D3Rs) modulate neuronal activity in several brain regions including the hippocampus. Although previous studies reported that blocking D3Rs exerts pro‐cognitive effects, their involvement in hippocampal synaptic funct…
View article: Nucleoporin 153 deficiency in adult neural stem cells defines a pathological protein-network signature and defective neurogenesis in a mouse model of AD
Nucleoporin 153 deficiency in adult neural stem cells defines a pathological protein-network signature and defective neurogenesis in a mouse model of AD Open
Background Reduction of adult hippocampal neurogenesis is an early critical event in Alzheimer’s disease (AD), contributing to progressive memory loss and cognitive decline. Reduced levels of the nucleoporin 153 (Nup153), a key epigenetic …
View article: HSV-1 infection induces phosphorylated tau propagation among neurons via extracellular vesicles
HSV-1 infection induces phosphorylated tau propagation among neurons via extracellular vesicles Open
Extracellular vesicles (EV), key players in cell-to-cell communication, may contribute to disease propagation in several neurodegenerative diseases, including Alzheimer’s disease (AD), by favoring the dissemination of neurotoxic proteins w…
View article: APP/AICD‐dependent expression of Glypican 4 mediates accumulation of tau oligomers in astrocytes and their synaptotoxic action
APP/AICD‐dependent expression of Glypican 4 mediates accumulation of tau oligomers in astrocytes and their synaptotoxic action Open
Background Several studies including ours reported the detrimental effects of extracellular tau oligomers (ex‐oTau) on glutamatergic synaptic transmission and plasticity. Astrocytes greatly internalize ex‐oTau thus contributing to their cl…
View article: Crosstalk between tau and alpha7 nicotinic acetylcholine receptors at the synapse
Crosstalk between tau and alpha7 nicotinic acetylcholine receptors at the synapse Open
Background The failure of cholinergic transmission and the increase of amyloid‐β peptide (Aβ) and tau protein are key players in Alzheimer’s disease (AD). The interaction between α7 nicotinic acetylcholine receptors (α7‐nAChRs) and Aβ has …
View article: Intracellular accumulation of tau oligomers in astrocytes and their synaptotoxic action rely on Amyloid Precursor Protein Intracellular Domain-dependent expression of Glypican-4
Intracellular accumulation of tau oligomers in astrocytes and their synaptotoxic action rely on Amyloid Precursor Protein Intracellular Domain-dependent expression of Glypican-4 Open
View article: Interleukin 1β triggers synaptic and memory deficits in Herpes simplex virus type-1-infected mice by downregulating the expression of synaptic plasticity-related genes via the epigenetic MeCP2/HDAC4 complex
Interleukin 1β triggers synaptic and memory deficits in Herpes simplex virus type-1-infected mice by downregulating the expression of synaptic plasticity-related genes via the epigenetic MeCP2/HDAC4 complex Open
Extensive research provides evidence that neuroinflammation underlies numerous brain disorders. However, the molecular mechanisms by which inflammatory mediators determine synaptic and cognitive dysfunction occurring in neurodegenerative d…
View article: A Bioengineering Strategy to Control ADAM10 Activity in Living Cells
A Bioengineering Strategy to Control ADAM10 Activity in Living Cells Open
A Disintegrin and Metalloprotease 10, also known as ADAM10, is a cell surface protease ubiquitously expressed in mammalian cells where it cuts several membrane proteins implicated in multiple physiological processes. The dysregulation of A…
View article: Cytoplasmic HDAC4 recovers synaptic function in the 3×Tg mouse model of Alzheimer's disease
Cytoplasmic HDAC4 recovers synaptic function in the 3×Tg mouse model of Alzheimer's disease Open
Aims Early dysfunction in Alzheimer's disease (AD) is characterised by alterations of synapse structure and function leading to dysmorphic neurites, decreased spine density, impaired synaptic plasticity and cognitive deficits. The class II…
View article: Extracellular tau oligomers affect extracellular glutamate handling by astrocytes through downregulation of GLT‐1 expression and impairment of NKA1A2 function
Extracellular tau oligomers affect extracellular glutamate handling by astrocytes through downregulation of GLT‐1 expression and impairment of NKA1A2 function Open
Aims Several studies reported that astrocytes support neuronal communication by the release of gliotransmitters, including ATP and glutamate. Astrocytes also play a fundamental role in buffering extracellular glutamate in the synaptic clef…
View article: Role of HSV-1 in Alzheimer's disease pathogenesis: A challenge for novel preventive/therapeutic strategies
Role of HSV-1 in Alzheimer's disease pathogenesis: A challenge for novel preventive/therapeutic strategies Open
View article: Genetic deletion of α7 nicotinic acetylcholine receptors induces an age-dependent Alzheimer’s disease-like pathology
Genetic deletion of α7 nicotinic acetylcholine receptors induces an age-dependent Alzheimer’s disease-like pathology Open
View article: Does Impairment of Adult Neurogenesis Contribute to Pathophysiology of Alzheimer's Disease? A Still Open Question
Does Impairment of Adult Neurogenesis Contribute to Pathophysiology of Alzheimer's Disease? A Still Open Question Open
Adult hippocampal neurogenesis is a physiological mechanism contributing to hippocampal memory formation. Several studies associated altered hippocampal neurogenesis with aging and Alzheimer's disease (AD). However, whether amyloid-β prote…
View article: Ca<sup>2+</sup>‐dependent release of <scp>ATP</scp> from astrocytes affects herpes simplex virus type 1 infection of neurons
Ca<sup>2+</sup>‐dependent release of <span>ATP</span> from astrocytes affects herpes simplex virus type 1 infection of neurons Open
Astrocytes provide metabolic support for neurons and modulate their functions by releasing a plethora of neuroactive molecules diffusing to neighboring cells. Here we report that astrocytes also play a role in cortical neurons' vulnerabili…
View article: Plasma BDNF Levels Following Transcranial Direct Current Stimulation Allow Prediction of Synaptic Plasticity and Memory Deficits in 3×Tg-AD Mice
Plasma BDNF Levels Following Transcranial Direct Current Stimulation Allow Prediction of Synaptic Plasticity and Memory Deficits in 3×Tg-AD Mice Open
Early diagnosis of Alzheimer's disease (AD) supposedly increases the effectiveness of therapeutic interventions. However, presently available diagnostic procedures are either invasive or require complex and expensive technologies, which ca…
View article: Tau is not necessary for amyloid-β–induced synaptic and memory impairments
Tau is not necessary for amyloid-β–induced synaptic and memory impairments Open
The amyloid hypothesis posits that the amyloid-beta (Aβ) protein precedes and requires microtubule-associated protein tau in a sort of trigger-bullet mechanism leading to Alzheimer's disease (AD) pathology. This sequence of events has beco…
View article: Herpes Simplex Virus-1 in the Brain: The Dark Side of a Sneaky Infection
Herpes Simplex Virus-1 in the Brain: The Dark Side of a Sneaky Infection Open
View article: The International Journal of Cell Differentiation and Proliferation
The International Journal of Cell Differentiation and Proliferation Open
View article: P3‐205: NITROSATIVE STRESS‐DEPENDENT NUP153 ALTERATION IMPAIRS NEURAL STEM CELL FUNCTION IN A MOUSE MODEL OF ALZHEIMER'S DISEASE
P3‐205: NITROSATIVE STRESS‐DEPENDENT NUP153 ALTERATION IMPAIRS NEURAL STEM CELL FUNCTION IN A MOUSE MODEL OF ALZHEIMER'S DISEASE Open
Impairment of adult hippocampal neurogenesis may contribute to cognitive decline in Alzheimer's disease (AD). Besides controlling nucleus-cytoplasm transport, the nuclear pore complex protein Nup153 has been recently described to affect ad…
View article: F2‐06‐02: TRAFFICKING OF TAU OLIGOMERS THROUGH THE PLASMA MEMBRANES OF NEURONS AND ASTROCYTES IS CRITICAL FOR THEIR SYNAPTOTOXICITY
F2‐06‐02: TRAFFICKING OF TAU OLIGOMERS THROUGH THE PLASMA MEMBRANES OF NEURONS AND ASTROCYTES IS CRITICAL FOR THEIR SYNAPTOTOXICITY Open
Tau protein has been recognized to play a key role in Alzheimer's disease pathogenesis. The accepted hypothesis is that hyperphosphorylated and misfolded tau accumulates intraneuronally thus impairing neuronal functions. However, soluble t…
View article: Neuromodulatory Action of Picomolar Extracellular Aβ42 Oligomers on Presynaptic and Postsynaptic Mechanisms Underlying Synaptic Function and Memory
Neuromodulatory Action of Picomolar Extracellular Aβ42 Oligomers on Presynaptic and Postsynaptic Mechanisms Underlying Synaptic Function and Memory Open
Failure of anti-amyloid-β peptide (Aβ) therapies against Alzheimer's disease (AD), a neurodegenerative disorder characterized by high amounts of the peptide in the brain, raised the question of the physiological role of Aβ released at low …
View article: Recurrent herpes simplex virus-1 infection induces hallmarks of neurodegeneration and cognitive deficits in mice
Recurrent herpes simplex virus-1 infection induces hallmarks of neurodegeneration and cognitive deficits in mice Open
Herpes simplex virus type 1 (HSV-1) is a DNA neurotropic virus, usually establishing latent infections in the trigeminal ganglia followed by periodic reactivations. Although numerous findings suggested potential links between HSV-1 and Alz…
View article: ForBioEnergy - Forest Bioenergy in the Protected Mediterranean Areas
ForBioEnergy - Forest Bioenergy in the Protected Mediterranean Areas Open
View article: The effect of amyloid-β peptide on synaptic plasticity and memory is influenced by different isoforms, concentrations, and aggregation status
The effect of amyloid-β peptide on synaptic plasticity and memory is influenced by different isoforms, concentrations, and aggregation status Open
View article: Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a
Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a Open
View article: LTP and memory impairment caused by extracellular Aβ and Tau oligomers is APP-dependent
LTP and memory impairment caused by extracellular Aβ and Tau oligomers is APP-dependent Open
The concurrent application of subtoxic doses of soluble oligomeric forms of human amyloid-beta (oAβ) and Tau (oTau) proteins impairs memory and its electrophysiological surrogate long-term potentiation (LTP), effects that may be mediated b…
View article: Author response: LTP and memory impairment caused by extracellular Aβ and Tau oligomers is APP-dependent
Author response: LTP and memory impairment caused by extracellular Aβ and Tau oligomers is APP-dependent Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract The concurrent application of subtoxic doses of soluble olig…