Domenico Corrado
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View article: Cardiopulmonary physical fitness and tissue characterization through T1 and T2 mapping: new insights on athlete’s heart
Cardiopulmonary physical fitness and tissue characterization through T1 and T2 mapping: new insights on athlete’s heart Open
Aims Regular vigorous exercise brings about cardiovascular adaptations, but the relationship between cardiac magnetic resonance-derived T1 and T2 mapping and physical fitness is not fully understood, with conflicting literature results. Th…
View article: Abnormal electrocardiogram findings in athletes
Abnormal electrocardiogram findings in athletes Open
Athletes commonly exhibit a series of electrical, structural, and functional physiological changes which may overlap with cardiac pathology. The last two decades have witnessed a progressive improvement in understanding what can be conside…
View article: Desmoglein-2 related Arrhythmogenic Cardiomyopathy: Integrative Genomic and Literature-based analysis with an Italian cohort-Level Validation
Desmoglein-2 related Arrhythmogenic Cardiomyopathy: Integrative Genomic and Literature-based analysis with an Italian cohort-Level Validation Open
Desmoglein-2 (DSG2) is a crucial desmosomal cadherin expressed in cardiomyocytes that contributes significantly to the development of arrhythmogenic cardiomyopathy (ACM), a condition characterized by variable onset and clinical presentatio…
View article: Prevalence and relation to training of electrocardiographic findings in Caucasian children and adolescents 8-18 year-old practicing competitive sport
Prevalence and relation to training of electrocardiographic findings in Caucasian children and adolescents 8-18 year-old practicing competitive sport Open
Background and Aims Training frequently induces electrocardiographic (ECG) changes that mimic heart diseases, requiring specific criteria for interpretation. Pediatric athletes represent a unique population as training-induced changes and …
View article: Modern Interpretation of Electrocardiogram and Premature Ventricular Beats in Athletes
Modern Interpretation of Electrocardiogram and Premature Ventricular Beats in Athletes Open
The electrocardiogram (ECG) is a non-invasive and cost-effective screening tool that is widely available and has been incorporated into many pre-participation screening programs for athletes. Despite historical criticisms regarding its sub…
View article: Outcome and Disease Progression in NYHA Functional Class I and II Patients With Wild-Type Transthyretin Cardiomyopathy Treated With Tafamidis
Outcome and Disease Progression in NYHA Functional Class I and II Patients With Wild-Type Transthyretin Cardiomyopathy Treated With Tafamidis Open
View article: Prevalence and characteristics of coronary artery disease in master athletes with ST-segment depression or high-risk premature ventricular beats at pre-participation exercise testing
Prevalence and characteristics of coronary artery disease in master athletes with ST-segment depression or high-risk premature ventricular beats at pre-participation exercise testing Open
Aims Whether exercise stress testing (ET) for early identification of coronary artery disease (CAD) should be performed for preparticipation screening (PPS) in all master athletes (MAs) or in high-risk athletes only remains debated. We eva…
View article: Prognostic significance of severe mitral annular calcification in aortic stenosis: implications for aortic valve replacement outcome
Prognostic significance of severe mitral annular calcification in aortic stenosis: implications for aortic valve replacement outcome Open
View article: Pharmacological Management of Transthyretin Amyloid Cardiomyopathy: Where We Are and Where We Are Going
Pharmacological Management of Transthyretin Amyloid Cardiomyopathy: Where We Are and Where We Are Going Open
Transthyretin (TTR) amyloid cardiomyopathy (ATTR-CM) is a progressive disease that has emerged as a significant cause of heart failure. Advances in the understanding of ATTR-CM pathophysiology have revolutionised its therapeutic landscape …
View article: Right ventricular to pulmonary artery uncoupling is an early predictor of poor outcome in wild-type transthyretin amyloid cardiomyopathy
Right ventricular to pulmonary artery uncoupling is an early predictor of poor outcome in wild-type transthyretin amyloid cardiomyopathy Open
View article: Does Long-Term Sport Practice Facilitate the Development of Idiopathic Bradycardia Requiring Early Pacemaker Implantation During the Course of Life?
Does Long-Term Sport Practice Facilitate the Development of Idiopathic Bradycardia Requiring Early Pacemaker Implantation During the Course of Life? Open
Background: Sinus bradycardia and first-/second-degree atrioventricular (AV) block in athletes are traditionally considered secondary to increased vagal tone and therefore reversible. However, recent studies have suggested that they may pe…
View article: The ‘Padua classification’ of cardiomyopathies into three groups: hypertrophic/restrictive, dilated/hypokinetic, and scarring/arrhythmogenic
The ‘Padua classification’ of cardiomyopathies into three groups: hypertrophic/restrictive, dilated/hypokinetic, and scarring/arrhythmogenic Open
The newly proposed classification of cardiomyopathies, referred to as ‘the Padua Classification’, is based on both pathobiological basis (genetics, molecular biology, and pathology) and clinical features (morpho-functional and structural v…
View article: Hypertrophic Cardiomyopathy: New Clinical and Therapeutic Perspectives of an “Old” Genetic Myocardial Disease
Hypertrophic Cardiomyopathy: New Clinical and Therapeutic Perspectives of an “Old” Genetic Myocardial Disease Open
Since its first pathological description over 65 years ago, hypertrophic cardiomyopathy (HCM), with a worldwide prevalence of 1:500, has emerged as the most common genetically determined cardiac disease. Diagnostic work-up has dramatically…
View article: Interpretation and management of T wave inversion in athletes: An expert opinion statement of the Italian Society of Sports Cardiology (SICSPORT)
Interpretation and management of T wave inversion in athletes: An expert opinion statement of the Italian Society of Sports Cardiology (SICSPORT) Open
View article: Long-term clinical outcomes of asymptomatic patients with spontaneous type 1 Brugada electrocardiographic pattern undergoing electrophysiologic study for risk stratification
Long-term clinical outcomes of asymptomatic patients with spontaneous type 1 Brugada electrocardiographic pattern undergoing electrophysiologic study for risk stratification Open
View article: Paradoxical improvement in exercise tolerance and peak VO2 consumption after treatment with ivabradine and beta-blockers in a patient with mild dilated cardiomyopathy and inappropriate sinus tachycardia—a case report
Paradoxical improvement in exercise tolerance and peak VO2 consumption after treatment with ivabradine and beta-blockers in a patient with mild dilated cardiomyopathy and inappropriate sinus tachycardia—a case report Open
Background Left bundle branch block (LBBB) is a rare conduction disorder in athletes associated with ventricular dyssynchrony, which can lead to left ventricular systolic dysfunction and exercise intolerance. Inappropriate sinus tachycardi…
View article: Electrocardiographic Clues for Early Diagnosis of Ventricular Pre-Excitation and Non-Invasive Risk Stratification in Athletes: A Practical Guide for Sports Cardiologists
Electrocardiographic Clues for Early Diagnosis of Ventricular Pre-Excitation and Non-Invasive Risk Stratification in Athletes: A Practical Guide for Sports Cardiologists Open
Ventricular pre-excitation (VP) is a cardiac disorder characterized by the presence of an accessory pathway (AP) that bypasses the atrioventricular node (AVN), which, although often asymptomatic, exposes individuals to an increased risk of…
View article: The Role of Nuclear Medicine in the Diagnostic Work-Up of Athletes: An Essential Guide for the Sports Cardiologist
The Role of Nuclear Medicine in the Diagnostic Work-Up of Athletes: An Essential Guide for the Sports Cardiologist Open
Athletes with heart disease are at increased risk of malignant ventricular arrhythmias and sudden cardiac death compared to their sedentary counterparts. When athletes have symptoms or abnormal findings at preparticipation screenings, a pr…
View article: Italian Cardiological Guidelines (COCIS) for Competitive Sport Eligibility in athletes with heart disease: update 2024
Italian Cardiological Guidelines (COCIS) for Competitive Sport Eligibility in athletes with heart disease: update 2024 Open
Nearly 35 years after its initial publication in 1989, the Italian Society of Sports Cardiology and the Italian Federation of Sports Medicine (FMSI), in collaboration with other leading Italian Cardiological Scientific Associations (ANCE -…
View article: Contemporary diagnostic approach to arrhythmogenic cardiomyopathy: The three-step work-up
Contemporary diagnostic approach to arrhythmogenic cardiomyopathy: The three-step work-up Open
View article: The 2023 European Task Force Criteria for Diagnosis of Arrhythmogenic Cardiomyopathy: Historical Background and Review of Main Changes
The 2023 European Task Force Criteria for Diagnosis of Arrhythmogenic Cardiomyopathy: Historical Background and Review of Main Changes Open
Arrhythmogenic cardiomyopathy (ACM) is a cardiac disease featured by non-ischemic myocardial scarring linked to ventricular electrical instability. As there is no single gold-standard test, diagnosing ACM remains challenging and a combinat…
View article: Left Ventricular Non-Compaction: Evolving Concepts
Left Ventricular Non-Compaction: Evolving Concepts Open
Left ventricular non-compaction (LVNC) is a rare heart muscle disease defined by the presence of prominent left ventricular trabeculation, deep intertrabecular recesses, and a thin compact layer. Several hypotheses have been proposed regar…
View article: The “Padua classification” of cardiomyopathies: Combining pathobiological basis and morpho-functional remodeling
The “Padua classification” of cardiomyopathies: Combining pathobiological basis and morpho-functional remodeling Open
Over the last 20 years, the scientific progresses in molecular biology and genetics in combination with the increasing use in the clinical setting of contrast-enhanced cardiac magnetic resonance (CMR) for morpho-functional imaging and stru…
View article: Cardiac sympathetic neurons are additional cells affected in genetically determined arrhythmogenic cardiomyopathy
Cardiac sympathetic neurons are additional cells affected in genetically determined arrhythmogenic cardiomyopathy Open
Arrhythmogenic cardiomyopathy (AC) is a familial cardiac disease, mainly caused by mutations in desmosomal genes, which accounts for most cases of stress‐related arrhythmic sudden death, in young and athletes. AC hearts display fibro‐fatty…
View article: A Comprehensive Analysis of Non-Desmosomal Rare Genetic Variants in Arrhythmogenic Cardiomyopathy: Integrating in Padua Cohort Literature-Derived Data
A Comprehensive Analysis of Non-Desmosomal Rare Genetic Variants in Arrhythmogenic Cardiomyopathy: Integrating in Padua Cohort Literature-Derived Data Open
Arrhythmogenic cardiomyopathy (ACM) is an inherited myocardial disease at risk of sudden death. Genetic testing impacts greatly in ACM diagnosis, but gene-disease associations have yet to be determined for the increasing number of genes in…
View article: Exploring low QRS voltages and QRS fragmentation in pediatric and adolescent athletes: prevalence and determinants factors
Exploring low QRS voltages and QRS fragmentation in pediatric and adolescent athletes: prevalence and determinants factors Open
Background Low QRS Voltages (LQRSV) in limb leads and QRS fragmentation (FQRS) are possible signs of myocardial fibrosis and cardiomyopathy, but they are not mentioned in the 2017 International Criteria for the interpretation of athlete’s …
View article: Interpretation of athlete's ECG in a pediatric population using the International Criteria
Interpretation of athlete's ECG in a pediatric population using the International Criteria Open
Background In Italy, the starting age for pre-participation screening (PPS) is defined by the single sports federations and sometimes includes individuals under the age of 12. Current International Criteria for ECG interpretation in athlet…
View article: International Criteria for Reporting Study Quality for Sudden Cardiac Arrest/Death Tool
International Criteria for Reporting Study Quality for Sudden Cardiac Arrest/Death Tool Open
Background Studies reporting on the incidence of sudden cardiac arrest and/or death (SCA/D) in athletes commonly lack methodological and reporting rigor, which has implications for screening and preventative policy in sport. To date, there…
View article: Prevalence and determinants of low QRS voltages and QRS fragmentation in children and adolescents undergoing sports pre-participation screening
Prevalence and determinants of low QRS voltages and QRS fragmentation in children and adolescents undergoing sports pre-participation screening Open
Aims Low QRS voltages (LQRSV) in limb leads and QRS fragmentation (FQRS) are possible electrocardiographic signs of myocardial fibrosis and cardiomyopathy, but they are not listed in current criteria for interpreting athlete’s electrocardi…
View article: The Challenges of Screening Master Athletes
The Challenges of Screening Master Athletes Open
In recent decades, there has been a significant increase in the number of men and women over the age of 40 participating in high-intensity endurance sports, often referred to as "master athletes." The "State of the Running 2019" report by …