Domenico M. Romeo
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View article: Application of the neonatal ‘floppy module’ to older infants: can it be used for differential diagnosis?
Application of the neonatal ‘floppy module’ to older infants: can it be used for differential diagnosis? Open
View article: Botulinum-Toxin-Induced Muscle Fasciculations in Children with Cerebral Palsy: A Case-Series Study
Botulinum-Toxin-Induced Muscle Fasciculations in Children with Cerebral Palsy: A Case-Series Study Open
Cerebral palsy (CP) is a group of permanent, but not immutable, disorders of movement and posture caused by a non-progressive lesion or an abnormality in the development of the immature brain. It is the leading cause of motor disability in…
View article: Development of the “SMA NNE,” a short neonatal neurological examination for newborns with spinal muscular atrophy
Development of the “SMA NNE,” a short neonatal neurological examination for newborns with spinal muscular atrophy Open
The advent of newborn screening for spinal muscular atrophy (SMA) has highlighted the need for easy, quick, clinical tools to be used in infants with SMA identified in the neonatal period. We propose a new short module developed using item…
View article: Sleep Disorders in Infants and Toddlers with Hypoxic Ischemic Encephalopathy Treated with Therapeutic Hypothermia: A Case–Control Study Using the SDSC
Sleep Disorders in Infants and Toddlers with Hypoxic Ischemic Encephalopathy Treated with Therapeutic Hypothermia: A Case–Control Study Using the SDSC Open
Background and Objectives: Sleep complaints are particularly relevant in the development of children, affecting cognitive development, neuropsychological functioning, and learning abilities. The aims of this study were as follows: (i) to d…
View article: Visual-semiquantitative and quantitative magnetic resonance imaging (MRI) data may predict outcome in congenital cytomegalovirus infection
Visual-semiquantitative and quantitative magnetic resonance imaging (MRI) data may predict outcome in congenital cytomegalovirus infection Open
The combined MRI score provides a reproducible tool to predict early neurodevelopmental impairments in cCMV patients, aiding clinicians in management and counselling.
View article: Construct Validity and Internal Consistency of the Italian Version of the PedsQLTM 4.0 Generic Core Scale and PedsQLTM 3.0 Cerebral Palsy Module
Construct Validity and Internal Consistency of the Italian Version of the PedsQLTM 4.0 Generic Core Scale and PedsQLTM 3.0 Cerebral Palsy Module Open
Background: Health-related quality of life (HRQoL) has emerged as a meaningful outcome measure in clinical trials and healthcare interventions in children with cerebral palsy (CwCP). We assessed the construct validity and internal consiste…
View article: Investigating the Overlap of Hikikomori and Autism Spectrum Disorder: A Case Report
Investigating the Overlap of Hikikomori and Autism Spectrum Disorder: A Case Report Open
Hikikomori is a form of social withdrawal lasting more than 6 months with significant associated functional impairment. To date, numerous studies confirm the presence of this condition not only in Japan, where it was first described, but a…
View article: Early Enoxaparin Treatment in a Newborn with Cerebral Venous Sinus Thrombosis and Acute Cerebellar Hemorrhage
Early Enoxaparin Treatment in a Newborn with Cerebral Venous Sinus Thrombosis and Acute Cerebellar Hemorrhage Open
To evaluate the management of anticoagulant therapy in neonates with cerebral sinus venous thrombosis (CSVT), focusing on potential benefits and risks. We report the case of a full-term neonate diagnosed with CSVT, highlighting the rationa…
View article: Environmental maternal exposures and the risk of premature birth and intrauterine growth restriction: The Generation Gemelli study protocol of newborn exposome
Environmental maternal exposures and the risk of premature birth and intrauterine growth restriction: The Generation Gemelli study protocol of newborn exposome Open
Background The study of women exposures and child outcomes occurring in the first 1,000 days of life since conception enhances understanding of the relationships between environmental factors, epigenetic changes, and disease development, e…
View article: Lung Recruitment Before Surfactant Administration in Extremely Preterm Neonates
Lung Recruitment Before Surfactant Administration in Extremely Preterm Neonates Open
Importance A multicenter randomized clinical trial (RCT) showed a lung recruitment maneuver using high-frequency oscillatory ventilation just before surfactant administration (ie, intubate-recruit-surfactant-extubate [IN-REC-SUR-E]) improv…
View article: The Hammersmith Infant Neurological Exam Scoring Aid supports early detection for infants with high probability of cerebral palsy
The Hammersmith Infant Neurological Exam Scoring Aid supports early detection for infants with high probability of cerebral palsy Open
This letter to the editor is in response to the original articles by Romeo et al. and Tian et al. on pages 1173–1180 and 1181–1189 of this issue.
View article: Sports Activities in Children with Cerebral Palsy: A Narrative Review
Sports Activities in Children with Cerebral Palsy: A Narrative Review Open
Physical exercise is known to have beneficial effects on psychosocial well-being and cognitive performance. Children with cerebral palsy (CP) showed lower levels of physical activity (PA) than healthy children; this fact, in addition to th…
View article: Ligamentous laxity in children with achondroplasia: Prevalence, joint involvement, and implications for early intervention strategies
Ligamentous laxity in children with achondroplasia: Prevalence, joint involvement, and implications for early intervention strategies Open
Achondroplasia (ACH), the most common form of skeletal dysplasia, is characterized by severe disproportionate short stature, rhizomelia, exaggerated lumbar lordosis, brachydactyly, macrocephaly with frontal bossing and midface hypoplasia. …
View article: Neurological assessment tool for screening infants during the first year after birth: The <scp>Brief‐Hammersmith</scp> Infant Neurological Examination
Neurological assessment tool for screening infants during the first year after birth: The <span>Brief‐Hammersmith</span> Infant Neurological Examination Open
Aim To develop a short version of the original Hammersmith Infant Neurological Examination (HINE) to be used as a screening tool (Brief‐HINE) and to establish if the short examination maintains good accuracy and predictive power for detect…
View article: pCO2 values in asphyxiated infants under therapeutic hypothermia after tailored respiratory management: a retrospective cohort study
pCO2 values in asphyxiated infants under therapeutic hypothermia after tailored respiratory management: a retrospective cohort study Open
Background Hypoxic-ischemic encephalopathy (HIE) represents one of the major causes of neonatal death and long-term neurological disability. Both hypoxic-ischemic insults and therapeutic hypothermia (TH) can affect respiratory function. Cu…
View article: Paediatric Neurology: Current Trends, Rehabilitation, and Future Challenges
Paediatric Neurology: Current Trends, Rehabilitation, and Future Challenges Open
Over the past 20 years, the introduction of new neurodevelopmental assessments and neurophysiological techniques has improved the knowledge of the complexity of the central nervous system in the first period of development [...]
View article: Relationship and New Prospectives in Joint Hypermobility in Children with Autism Spectrum Disorder: Preliminary Data
Relationship and New Prospectives in Joint Hypermobility in Children with Autism Spectrum Disorder: Preliminary Data Open
Autism spectrum disorder (ASD) and joint hypermobility (JH) are considered two different etiological and clinical entities that most often appear in childhood. Despite growing increased research showing a co-occurrence for both conditions,…
View article: Intranasal human-recombinant NGF administration improves outcome in children with post-traumatic unresponsive wakefulness syndrome
Intranasal human-recombinant NGF administration improves outcome in children with post-traumatic unresponsive wakefulness syndrome Open
Background Severe traumatic brain injury (TBI) is one of the most dramatic events in pediatric age and, despite advanced neuro-intensive care, the survival rate of these patients remains low. Children suffering from severe TBI show long-te…
View article: How pain affect real life of children and adults with achondroplasia: A systematic review
How pain affect real life of children and adults with achondroplasia: A systematic review Open
View article: Sleep Disorders in Low-Risk Preterm Infants and Toddlers
Sleep Disorders in Low-Risk Preterm Infants and Toddlers Open
Sleep disorders are particularly important in the development of children, affecting the emotional, behavioural, and cognitive spheres. The incidence of these disorders has been assessed in different types of populations, including patient…
View article: Combined treatment of nerve growth factor and transcranical direct current stimulations to improve outcome in children with vegetative state after out-of-hospital cardiac arrest
Combined treatment of nerve growth factor and transcranical direct current stimulations to improve outcome in children with vegetative state after out-of-hospital cardiac arrest Open
View article: Eye Movement Desensitization and Reprocessing (EMDR) as a Possible Evidence-Based Rehabilitation Treatment Option for a Patient with ADHD and History of Adverse Childhood Experiences: A Case Report Study
Eye Movement Desensitization and Reprocessing (EMDR) as a Possible Evidence-Based Rehabilitation Treatment Option for a Patient with ADHD and History of Adverse Childhood Experiences: A Case Report Study Open
Background: Children with Attention Deficit Hyperactivity Disorder (ADHD) having a history of adverse childhood experiences (ACEs) could be very difficult to treat with standard psychotherapeutic approaches. Some children diagnosed with AD…
View article: What to Expect of Feeding Abilities and Nutritional Aspects in Achondroplasia Patients: A Narrative Review
What to Expect of Feeding Abilities and Nutritional Aspects in Achondroplasia Patients: A Narrative Review Open
Achondroplasia is an autosomal dominant genetic disease representing the most common form of human skeletal dysplasia: almost all individuals with achondroplasia have identifiable mutations in the fibroblast growth factor receptor type 3 (…
View article: Neurodevelopmental Outcomes in Preterm Infants Receiving a Multicomponent vs. a Soybean-Based Lipid Emulsion: 24 Month Follow-Up of a Randomized Controlled Trial
Neurodevelopmental Outcomes in Preterm Infants Receiving a Multicomponent vs. a Soybean-Based Lipid Emulsion: 24 Month Follow-Up of a Randomized Controlled Trial Open
Background: Few studies in the literature have analyzed the long-term neurodevelopmental outcomes of the administration of a multicomponent versus a soybean-based lipid emulsion (LE) in preterm infants receiving parenteral nutrition (PN). …
View article: The Use of the 6MWT for Rehabilitation in Children with Cerebral Palsy: A Narrative Review
The Use of the 6MWT for Rehabilitation in Children with Cerebral Palsy: A Narrative Review Open
Assessing and improving walking abilities is considered one of the most important functional goals of physical therapy in children with cerebral palsy. However, there is still a gap in knowledge regarding the efficacy of treatment targetin…
View article: Perinatal Cerebral Ischemic Lesion and SARS-CoV-2 Infection during Pregnancy: A Case Report and a Review of the Literature
Perinatal Cerebral Ischemic Lesion and SARS-CoV-2 Infection during Pregnancy: A Case Report and a Review of the Literature Open
Perinatal stroke is related to possible differences in predisposing factors and outcomes between acutely and retrospectively diagnosed cases. In most cases, there are different risk factors and infections that could play an important role.…
View article: Maternal Ureaplasma/Mycoplasma colonization during pregnancy and neurodevelopmental outcomes for preterm infants
Maternal Ureaplasma/Mycoplasma colonization during pregnancy and neurodevelopmental outcomes for preterm infants Open
Introduction Ureaplasma ( U .) and Mycoplasma ( M .) species have been related to pregnancy complications (including preterm birth) and worse neonatal outcomes. The aim of our work is to evaluate neurodevelopmental outcomes in preterm infa…
View article: Developmental Coordination Disorder and Joint Hypermobility in Childhood: A Narrative Review
Developmental Coordination Disorder and Joint Hypermobility in Childhood: A Narrative Review Open
Children with developmental coordination disorder (DCD) and joint hypermobility could present an overlap of symptoms and motor functional difficulties. The link between these two clinical conditions has not yet been clarified. Recent studi…
View article: Assessing floppy infants: a new module
Assessing floppy infants: a new module Open
View article: Hammersmith Infant Neurological Examination in low‐risk infants born very preterm: a longitudinal prospective study
Hammersmith Infant Neurological Examination in low‐risk infants born very preterm: a longitudinal prospective study Open
Aim To describe the profile of global and single items of the Hammersmith Infant Neurological Examination (HINE) in a population of low‐risk infants born very preterm during the first year of life. Method The HINE was performed at 3, 6, 9,…