Domenico Rosa
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View article: Peri-intubation adverse events and clinical outcomes in emergency department patients: the BARCO study
Peri-intubation adverse events and clinical outcomes in emergency department patients: the BARCO study Open
One in three patients undergoing emergency intubation experienced a major peri-intubation adverse event, which was associated with higher 28-day mortality. These results underscore the importance of optimizing intubation strategies to redu…
View article: A phase I, randomized, controlled, dose-ranging study of investigational acellular pertussis (aP) and reduced tetanus-diphtheria-acellular pertussis (TdaP) booster vaccines in adults
A phase I, randomized, controlled, dose-ranging study of investigational acellular pertussis (aP) and reduced tetanus-diphtheria-acellular pertussis (TdaP) booster vaccines in adults Open
Despite high vaccination coverage worldwide, pertussis has re-emerged in many countries. This randomized, controlled, observer-blind phase I study and extension study in Belgium (March 2012-June 2015) assessed safety and immunogenicity of …
View article: Early Rise of Blood T Follicular Helper Cell Subsets and Baseline Immunity as Predictors of Persisting Late Functional Antibody Responses to Vaccination in Humans
Early Rise of Blood T Follicular Helper Cell Subsets and Baseline Immunity as Predictors of Persisting Late Functional Antibody Responses to Vaccination in Humans Open
CD4+ T follicular helper cells (T(FH)) have been identified as the T-cell subset specialized in providing help to B cells for optimal activation and production of high affinity antibody. We recently demonstrated that the expansion of perip…
View article: Effect of different stimuli on the frequencies of CD19<sup>+</sup>CD20<sup>+</sup>GM-CSF<sup>+</sup> cells.
Effect of different stimuli on the frequencies of CD19<sup>+</sup>CD20<sup>+</sup>GM-CSF<sup>+</sup> cells. Open
Ex-vivo cells from tonsils (5 x 105 cells/well) were stimulated for 2 days at 37°C in the presence of IL-2 with or without polyclonal stimuli (anti-IgM 10 μg/ml or SAC 1:20.000 final) or TLR9 ligand (CpG at 10 μg/ml). Bre…
View article: Innate Response Activator (IRA) B Cells Reside in Human Tonsils and Internalize Bacteria In Vitro
Innate Response Activator (IRA) B Cells Reside in Human Tonsils and Internalize Bacteria In Vitro Open
Innate response activator (IRA) B cells have been described in mice as a subset of B-1a B cells that produce granulocyte/macrophage colony-stimulating factor (GM-CSF) and have been found in the spleen upon activation. In humans, identifica…