Dominic Maggio
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View article: Clio: Real-time Task-Driven Open-Set 3D Scene Graphs
Clio: Real-time Task-Driven Open-Set 3D Scene Graphs Open
Modern tools for class-agnostic image segmentation (e.g., SegmentAnything) and open-set semantic understanding (e.g., CLIP) provide unprecedented opportunities for robot perception and mapping. While traditional closed-set metric-semantic …
View article: VERF: Runtime Monitoring of Pose Estimation with Neural Radiance Fields
VERF: Runtime Monitoring of Pose Estimation with Neural Radiance Fields Open
We present VERF, a collection of two methods (VERF-PnP and VERF-Light) for providing runtime assurance on the correctness of a camera pose estimate of a monocular camera without relying on direct depth measurements. We leverage the ability…
View article: A Correct-and-Certify Approach to Self-Supervise Object Pose Estimators via Ensemble Self-Training
A Correct-and-Certify Approach to Self-Supervise Object Pose Estimators via Ensemble Self-Training Open
Real-world robotics applications demand object pose estimation methods that work reliably across a variety of scenarios.Modern learning-based approaches require large labeled datasets and tend to perform poorly outside the training domain.…
View article: Comparison of Transforaminal Lumbar Interbody Fusion in the Ambulatory Surgery Center and Traditional Hospital Settings, Part 2: Assessment of Surgical Safety in Medicare Beneficiaries
Comparison of Transforaminal Lumbar Interbody Fusion in the Ambulatory Surgery Center and Traditional Hospital Settings, Part 2: Assessment of Surgical Safety in Medicare Beneficiaries Open
(1) Background: The clinical benefits and procedural efficiencies of performing minimally invasive fusion procedures, such as transforaminal lumbar interbody fusion (TLIF), in the ambulatory surgery center (ASC) are becoming increasingly w…
View article: Vision-Based Terrain Relative Navigation on High-Altitude Balloon and Sub-Orbital Rocket
Vision-Based Terrain Relative Navigation on High-Altitude Balloon and Sub-Orbital Rocket Open
We present an experimental analysis on the use of a camera-based approach for high-altitude navigation by associating mapped landmarks from a satellite image database to camera images, and by leveraging inertial sensors between camera fram…
View article: A Correct-and-Certify Approach to Self-Supervise Object Pose Estimators via Ensemble Self-Training
A Correct-and-Certify Approach to Self-Supervise Object Pose Estimators via Ensemble Self-Training Open
Real-world robotics applications demand object pose estimation methods that work reliably across a variety of scenarios. Modern learning-based approaches require large labeled datasets and tend to perform poorly outside the training domain…
View article: Loc-NeRF: Monte Carlo Localization using Neural Radiance Fields
Loc-NeRF: Monte Carlo Localization using Neural Radiance Fields Open
We present Loc-NeRF, a real-time vision-based robot localization approach that combines Monte Carlo localization and Neural Radiance Fields (NeRF). Our system uses a pre-trained NeRF model as the map of an environment and can localize itse…
View article: Spinal deformity correction in ankylosing spondylitis
Spinal deformity correction in ankylosing spondylitis Open
Background: Ankylosing spondylitis (AS) is a complex, debilitating disease with few available medical therapies in its later stages. Methods: We reviewed current clinical approaches for caring for AS patients with an emphasis on the risks …
View article: FGFR1-TACC1 fusion associated with malignant transformation in a primary spinal cord glioma: a case report
FGFR1-TACC1 fusion associated with malignant transformation in a primary spinal cord glioma: a case report Open
Molecular mechanisms of malignant transformation in spinal cord gliomas are not well-understood. Our objective was to investigate genetic causes of malignant transformation in a primary spinal cord glioma. A 32-year-old female patient pres…
View article: Inhibition of protein phosphatase-2A with LB-100 enhances antitumor immunity against glioblastoma
Inhibition of protein phosphatase-2A with LB-100 enhances antitumor immunity against glioblastoma Open
View article: Adult revision surgery of prior hook-and-rod wire instrumentation for idiopathic scoliosis
Adult revision surgery of prior hook-and-rod wire instrumentation for idiopathic scoliosis Open
Adolescent idiopathic scoliosis patients treated with spinal fusion may develop adjacent segment disease and curve progression into adulthood. Revision operations can be challenging, especially for adult patients treated with outdated inst…
View article: Resection of von Hippel Lindau Related Brainstem Hemangioblastoma
Resection of von Hippel Lindau Related Brainstem Hemangioblastoma Open
Patients with von Hippel Lindau (VHL) disease develop multiple central nervous system hemangioblastomas (HB). The surgical resection of VHL-HBs is the standard of clinical care when these HBs become symptomatic due to tumor growth, edema, …
View article: Chiari Malformation Type 1 in EPAS1-Associated Syndrome
Chiari Malformation Type 1 in EPAS1-Associated Syndrome Open
A syndrome of multiple paragangliomas/pheochromocytomas, somatostatinoma, and polycythemia due to somatic mosaic gain-of-function mutation of EPAS1, encoding HIF-2α, was previously described. HIF-2α has been implicated in endochondral and …
View article: Resection of Myxopapillary Ependymoma of the Filum Terminale: 2-Dimensional Operative Video
Resection of Myxopapillary Ependymoma of the Filum Terminale: 2-Dimensional Operative Video Open
We present the case of a 48-yr-old female who presented with persistent thigh pain and was found to have a heterogeneous mass caudal to the conus most consistent with a myxopapillary ependymoma. We performed L2-3 laminectomies for tumor re…
View article: Pharmacologic inhibition of protein phosphatase-2A achieves durable immune-mediated antitumor activity when combined with PD-1 blockade
Pharmacologic inhibition of protein phosphatase-2A achieves durable immune-mediated antitumor activity when combined with PD-1 blockade Open
View article: Isocitrate dehydrogenase 2 mutations correlate with leukemic transformation and are predicted by 2-hydroxyglutarate in myelodysplastic syndromes
Isocitrate dehydrogenase 2 mutations correlate with leukemic transformation and are predicted by 2-hydroxyglutarate in myelodysplastic syndromes Open
View article: Publisher Correction: PP2A inhibition from LB100 therapy enhances daunorubicin cytotoxicity in secondary acute myeloid leukemia via miR-181b-1 upregulation
Publisher Correction: PP2A inhibition from LB100 therapy enhances daunorubicin cytotoxicity in secondary acute myeloid leukemia via miR-181b-1 upregulation Open
View article: IMMU-55. PHARMACOLOGIC INHIBITION OF PROTEIN PHOSPHATASE-2A, WITH NOVEL INHIBITOR LB-100, ACHIEVES DURABLE IMMUNE-MEDIATED ANTITUMOR ACTIVITY WHEN COMBINED WITH PD1 BLOCKADE
IMMU-55. PHARMACOLOGIC INHIBITION OF PROTEIN PHOSPHATASE-2A, WITH NOVEL INHIBITOR LB-100, ACHIEVES DURABLE IMMUNE-MEDIATED ANTITUMOR ACTIVITY WHEN COMBINED WITH PD1 BLOCKADE Open
BACKGROUND: Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase. Mounting evidences suggest that inhibition of PP2A could enhance cancer immunity. LB-100 is a novel small molecule inhibitor of PP2A that is well tolerated in a P…
View article: EXTH-11. PD-1 ANTAGONISM WITH CONCURRENT COMPETITIVE INHIBITION OF PP2A PROMOTES ENHANCED REGRESSION OF INTRACRANIAL GLIOBLASTOMA
EXTH-11. PD-1 ANTAGONISM WITH CONCURRENT COMPETITIVE INHIBITION OF PP2A PROMOTES ENHANCED REGRESSION OF INTRACRANIAL GLIOBLASTOMA Open
BACKGROUND: Checkpoint inhibition using monoclonal antibodies against PD-1 is currently under evaluation for treatment of glioblastoma (GBM). Inhibition of protein phosphatase 2A (PP2a) was recently identified as a novel strategy to enhanc…
View article: PP2A inhibition from LB100 therapy enhances daunorubicin cytotoxicity in secondary acute myeloid leukemia via miR-181b-1 upregulation
PP2A inhibition from LB100 therapy enhances daunorubicin cytotoxicity in secondary acute myeloid leukemia via miR-181b-1 upregulation Open
View article: Vorinostat suppresses hypoxia signaling by modulating nuclear translocation of hypoxia inducible factor 1 alpha
Vorinostat suppresses hypoxia signaling by modulating nuclear translocation of hypoxia inducible factor 1 alpha Open
Histone deacetylase inhibitors (HDACis) are a potent class of tumor-suppressive agents traditionally believed to exert their effects through loosening tightly-wound chromatin resulting in de-inhibition of various tumor suppressive genes. R…
View article: Functional Outcome After Resection of Von Hippel-Lindau Disease-Associated Cauda Equina Hemangioblastomas: An Observational Cohort Study
Functional Outcome After Resection of Von Hippel-Lindau Disease-Associated Cauda Equina Hemangioblastomas: An Observational Cohort Study Open
BACKGROUND: Cauda equina hemangioblastomas in von Hippel-Lindau (VHL) disease can cause significant neurological signs and symptoms. Despite their associated morbidity, the management of these tumors remains incompletely defined. OBJECTIVE…
View article: Identifying the Long-Term Role of Inducible Nitric Oxide Synthase after Contusive Spinal Cord Injury Using a Transgenic Mouse Model
Identifying the Long-Term Role of Inducible Nitric Oxide Synthase after Contusive Spinal Cord Injury Using a Transgenic Mouse Model Open
Inducible nitric oxide synthase (iNOS) is a potent mediator of oxidative stress during neuroinflammation triggered by neurotrauma or neurodegeneration. We previously demonstrated that acute iNOS inhibition attenuated iNOS levels and promot…
View article: Assessment of impact of standing long-cassette radiographs on surgical planning for lumbar pathology: an international survey of spine surgeons
Assessment of impact of standing long-cassette radiographs on surgical planning for lumbar pathology: an international survey of spine surgeons Open
OBJECT The associations among global spinal alignment, patient-reported disability, and surgical outcomes have increasingly gained attention. The assessment of global spinal alignment requires standing long-cassette anteroposterior and lat…
Canadian Spine Society01.1.1: Surgery versus standardized nonoperative care for the treatment of lumbar disc herniations: a Canadian trial02.1.1: Wait times for elective spine surgery across Canada: data from the Canadian Spine Outcomes and Research Network03.1.1: Presurgical physician utilization in elective thoracolumbar spine surgery candidates: a nationwide analysis from the CSORN database04.1.2: Activities performed and treatments conducted prior to consultation with a spine surgeon: Are patients and clinicians following evidence-based clinical practice guidelines?05.1.2: Patient-reported disability versus objective physical performance measures in assessing patient recovery06.1.2: Risk factors for work status in low back pain patients: a cross-sectional analysis of patients presenting to the Ontario Inter-professional Spine Assessment and Education Clinics07.1.3: Comparison of symptomatic, functional and demographic characteristics of postsurgical versus nonoperative LBP patients08.1.3: Are primary care patients with different patterns of low back pain epidemiologically distinct?09.1.3: Lack of prognostic model validation in low back pain prediction studies10.1.4: Larger scoliosis curve magnitude is associated with increased surgical and perioperative complications: a multi-centre analysis of 1173 adolescent idiopathic scoliosis curves11.1.4: Superior extension of upper instrumented level in distraction-based surgery: a surrogate for clinically significant PJK12.1.4: The optimal surgical approach for Lenke 5 curves: Is the anterior approach ready for a comeback?13.1.5: Improving quality and safety in pediatric spine surgery: the team approach14.1.5: Posterior vertebral column resection in pediatric deformity: the advantages of staging15.1.5: Minimally invasive surgery in adolescent idiopathic scoliosis: lessons learned at mean 2-year follow-up16.2.1: Development of a Canadian competency-based spine surgery fellowship education curriculum17.2.1: Computer-assisted surgery is an effective educational tool for the training of orthopedic surgery residents in pedicle screw placement18.2.1: Validation of the Calgary Spine Severity Score19.2.2: Can triaging referrals with a simple 3-item pain questionnaire reduce wait times for consultations for patients who would benefit from lumbar spinal surgery?20.2.2: Strategies to improve the credibility of meta-analyses in spine surgery: a systematic survey21.2.2: The societal cost of waiting to see a spine surgeon for lower back symptoms in Canada22.2.3: The cost of an adverse event depends on its definition and method of capture23.2.3: Economic evaluation of intraoperative cone beam CT-based navigation for the placement of spinal pedicle screws: a patient-level cost-effectiveness analysis24.2.3: Predictors of inappropriate emergency department utilization following elective thoracolumbar spine surgery25.2.4: Incidence, impact and risk factors of adverse events in thoracic and lumbar spine fractures. An ambispective cohort analysis of 390 patients26.2.4: Factors associated with adverse events in major elective spine, knee, and hip in-patient orthopedic surgery27.2.4: Prognostic factors for survival in surgical series of symptomatic metastatic epidural spinal cord compression: a prospective North American multicentre study in 142 patients28.2.5: A comparison of 2 prospective adverse event recording tools with institutional ICD-10 coding for detecting perioperative adverse events in patients undergoing spinal surgery29.2.5: Assessment of impact of long-cassette standing radiographs on surgical planning for lumbar pathology: an international survey of spine surgeons30.2.5: Long-term patient-reported outcome and surgical survivorship of MIS fusion for low-grade spondylolisthesis31.3.1: The effect of prolonged postoperative antibiotic administration on the rate of infection in patients undergoing posterior spine surgery requiring a Hemovac drain32.3.1: Preliminary results of a Phase 1 trial on the use of photodynamic therapy in vertebral metastases33.3.1: The minimal clinically important difference of the modified Japanese Orthopaedic Association score in patients with degenerative cervical myelopathy undergoing surgical intervention34.3.1: Patient and surgeon radiation exposure during spinal instrumentation using intraoperative CT-based navigation35.3.2: Are postoperative pelvic parameters and sagittal balance predictive of further lumbar surgery in patients with spinal stenosis?36.3.2: Postoperative ambulation in patients undergoing total hip arthroplasty, total knee arthroplasty and elective lumbar spine surgery to treat arthritic pathologies37.3.2 Pain on the brain: Is the SF-36 mental component summary enough?38.3.2: Accurate and safe cervical osteotomy for kyphotic deformity in ankylosing spondylitis39.3.3: Adjacent segment pathology in the lumbar spine: progressive disease or a consequence of iatrogenic fusion?40.3.3: The association of cervical spine alignment with Open