Dominic Pühringer
YOU?
Author Swipe
View article: Growth of complete ammonia oxidizers on guanidine
Growth of complete ammonia oxidizers on guanidine Open
View article: Bacterial Lactonases ZenA with Noncanonical Structural Features Hydrolyze the Mycotoxin Zearalenone
Bacterial Lactonases ZenA with Noncanonical Structural Features Hydrolyze the Mycotoxin Zearalenone Open
Zearalenone (ZEN) is a mycoestrogenic polyketide produced by Fusarium graminearum and other phytopathogenic members of the genus Fusarium. Contamination of cereals with ZEN is frequent, and hydrolytic detoxification with fung…
View article: Unlocking Predictive Power: A Machine Learning Tool Derived from In-Depth Analysis to Forecast the Impact of Missense Variants in Human Filamin C
Unlocking Predictive Power: A Machine Learning Tool Derived from In-Depth Analysis to Forecast the Impact of Missense Variants in Human Filamin C Open
Cardiomyopathies, diseases of the heart muscle, are a leading cause of heart failure. An increasing proportion of cardiomyopathies have been associated with specific genetic changes, such as mutations in FLNC , the gene that codes for fila…
View article: A conformation-specific ON-switch for controlling CAR T cells with an orally available drug
A conformation-specific ON-switch for controlling CAR T cells with an orally available drug Open
Molecular ON-switches in which a chemical compound induces protein–protein interactions can allow cellular function to be controlled with small molecules. ON-switches based on clinically applicable compounds and human proteins would greatl…
View article: Structural and functional characterization of phosphoglucomutase 5
Structural and functional characterization of phosphoglucomutase 5 Open
Phosphoglucomutase-like protein 5 (PGM5), also known as "Aciculin" or phosphoglucomutase-related protein (PGM-RP) is a member of the phosphohexose mutase protein family.It is closely related to phosphoglucomutase 1 (PGM1), which catalyzes …
View article: Redox Cofactor Rotates during Its Stepwise Decarboxylation: Molecular Mechanism of Conversion of Coproheme to Heme <i>b</i>.
Redox Cofactor Rotates during Its Stepwise Decarboxylation: Molecular Mechanism of Conversion of Coproheme to Heme <i>b</i>. Open
Coproheme decarboxylase (ChdC) catalyzes the last step in the heme biosynthesis pathway of monoderm bacteria with coproheme acting both as redox cofactor and substrate. Hydrogen peroxide mediates the stepwise decarboxylation of propionates…
View article: Redox Cofactor Rotates during Its Stepwise Decarboxylation: Molecular Mechanism of Conversion of Coproheme to Heme <i>b</i>
Redox Cofactor Rotates during Its Stepwise Decarboxylation: Molecular Mechanism of Conversion of Coproheme to Heme <i>b</i> Open
Coproheme decarboxylase (ChdC) catalyzes the last step in the heme biosynthesis pathway of monoderm bacteria with coproheme acting both as redox cofactor and substrate. Hydrogen peroxide mediates the stepwise decarboxylation of propionates…
View article: Molecular Mechanism of Enzymatic Chlorite Detoxification: Insights from Structural and Kinetic Studies
Molecular Mechanism of Enzymatic Chlorite Detoxification: Insights from Structural and Kinetic Studies Open
The heme enzyme chlorite dismutase (Cld) catalyzes the degradation of chlorite to chloride and dioxygen. Although structure and steady-state kinetics of Clds have been elucidated, many questions remain (e.g., the mechanism of chlorite clea…
View article: Hydrogen peroxide‐mediated conversion of coproheme to heme <i>b</i> by HemQ—lessons from the first crystal structure and kinetic studies
Hydrogen peroxide‐mediated conversion of coproheme to heme <i>b</i> by HemQ—lessons from the first crystal structure and kinetic studies Open
Heme biosynthesis in Gram‐positive bacteria follows a recently described coproporphyrin‐dependent pathway with HemQ catalyzing the decarboxylation of coproheme to heme b . Here we present the first crystal structure of a HemQ (homopentamer…