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View article: Identifying Essential Information for a Valid Informed Consent of Egg Donors: An International Delphi Study
Identifying Essential Information for a Valid Informed Consent of Egg Donors: An International Delphi Study Open
View article: P-802 Unraveling a distinct role for GATA3 in mouse and human trophectoderm development via CRISPR/Cas9 gene editing
P-802 Unraveling a distinct role for GATA3 in mouse and human trophectoderm development via CRISPR/Cas9 gene editing Open
Study question What is the function of GATA3 in mouse and human trophectoderm (TE) formation, and does its function differ between species? Summary answer GATA3 is dispensable for mouse blastocyst formation, whereas GATA3 is suggested to b…
View article: P-405 Enhancing Oocyte Maturation in Transgender Men: The Role of CAPA-IVM in Fertility Preservation
P-405 Enhancing Oocyte Maturation in Transgender Men: The Role of CAPA-IVM in Fertility Preservation Open
Study question Can C-type natriuretic peptide (CNP) based CAPA-IVM (Capacitation in-vitro maturation) improve ovarian tissue oocyte (OTO) maturation competence in transgender patients? Summary answer CAPA-IVM improves oocyte maturation but…
View article: O-203 Improved live birth rates and reduced miscarriage rates per single embryo transfer through aneuploidy screening in young patients undergoing PGT-M
O-203 Improved live birth rates and reduced miscarriage rates per single embryo transfer through aneuploidy screening in young patients undergoing PGT-M Open
Study question Is additional ploidy screening (PGT-A) on blastocysts screened for monogenic conditions (PGT-M) of any added value? Summary answer Additional ploidy screening improved live birth rates per single embryo transfer and signific…
View article: O-188 Serum progesterone on day of frozen embryo transfer (FET), including non-rescued patients with low progesterone, does not impact outcome: a prospective analysis and randomized trial
O-188 Serum progesterone on day of frozen embryo transfer (FET), including non-rescued patients with low progesterone, does not impact outcome: a prospective analysis and randomized trial Open
Study question Do serum progesterone (P4) levels ≥ or < 10ng/ml, with or without rescue strategy, influence ongoing pregnancy rates (OPR) in artificial frozen embryo transfer (FET) cycles? Summary answer OPR was comparable in patients w…
View article: P-531 The experiences of trans masculine individuals and their health care providers within preconception and prenatal care
P-531 The experiences of trans masculine individuals and their health care providers within preconception and prenatal care Open
Study question What are the experiences, barriers and needs of pregnant trans masculine individuals and their healthcare providers within preconception and prenatal care? Summary answer Trans masculine people and their healthcare providers…
View article: O-069 Mito-TALENs reduce mitochondrial DNA mutation load following pronuclear transfer
O-069 Mito-TALENs reduce mitochondrial DNA mutation load following pronuclear transfer Open
Study question Can mito-TALENs selectively eliminate mitochondrial DNA (mtDNA) carryover following pronuclear transfer (PNT) in a mouse model carrying a heteroplasmic mtDNA mutation? Summary answer Mito-TALENs effectively reduced mitochond…
View article: P-699 The effect of transdermal testosterone on biochemical and sonographic markers of ovarian reserve in women with diminished ovarian reserve in a randomised placebo-controlled trial
P-699 The effect of transdermal testosterone on biochemical and sonographic markers of ovarian reserve in women with diminished ovarian reserve in a randomised placebo-controlled trial Open
Study question Does transdermal testosterone treatment improve markers of ovarian reserve compared to placebo in infertile women with diminished ovarian reserve (DOR) according to the Bologna criteria? Summary answer Transdermal testostero…
View article: P-594 Genetic screening in patients with oocyte/zygote/embryo maturation arrest and failed fertilization
P-594 Genetic screening in patients with oocyte/zygote/embryo maturation arrest and failed fertilization Open
Study question Can variant screening identify the genetic causes of female-related oocyte/zygote/embryo maturation arrest (OZEMA) and male-related failed fertilization (FF)? Summary answer Genetic analysis revealed CHEK1/WEE2/TUBB8 mutatio…
View article: P-684 Random Start Progestin-Primed Ovarian Stimulation (RS-PPOS) using oral Natural Micronized Progesterone (NMP) versus basal start gonadotropin-releasing hormone (GnRH) antagonist; analysis of 625 elective freeze-all cycles
P-684 Random Start Progestin-Primed Ovarian Stimulation (RS-PPOS) using oral Natural Micronized Progesterone (NMP) versus basal start gonadotropin-releasing hormone (GnRH) antagonist; analysis of 625 elective freeze-all cycles Open
Study question Does the random start PPOS protocol using NMP provide an effective and flexible alternative to the early follicular start GnRH antagonist protocol for elective freeze-all? Summary answer The random start PPOS protocol achiev…
View article: P-253 Determination of age-specific diagnostic criteria for OZEMA (Oocyte/Zygote/Embryo Maturation Arrest) phenotypes based on 16,994 cycles
P-253 Determination of age-specific diagnostic criteria for OZEMA (Oocyte/Zygote/Embryo Maturation Arrest) phenotypes based on 16,994 cycles Open
Study question Can cut-off values for oocyte maturation rate (OMR), fertilization rate (FR) and blastocyst formation rate (BFR) be established to define OZEMA (Oocyte/Zygote/Embryo Maturation arrest) phenotypes? Summary answer This study i…
View article: O-286 Regional variability in ovarian stimulation necessitates region-specific machine learning models for optimizing oocyte yield
O-286 Regional variability in ovarian stimulation necessitates region-specific machine learning models for optimizing oocyte yield Open
Study question Can a machine learning model trained on US data accurately predict eggs retrieved for EU ovarian stimulation patients? Summary answer An EU-specific model is required for higher accuracy due to differences in egg outcomes an…
View article: O-222 Identifying essential information for a valid informed consent (IC) of egg donors: An international Delphi study
O-222 Identifying essential information for a valid informed consent (IC) of egg donors: An international Delphi study Open
Study question What information does an international group of professionals and egg donors consider relevant and morally necessary for prospective egg donors to provide valid IC? Summary answer Participants considered 80% of all concrete …
View article: P-803 Reconstructing oocytes via haploidization: Challenges in development, ploidy, and chromosome dynamics
P-803 Reconstructing oocytes via haploidization: Challenges in development, ploidy, and chromosome dynamics Open
Study question Is the efficiency of creating euploid embryos by haploidization affected by genetic background and source of donor cell? Summary answer Euploid embryos can be obtained irrespective of genetic background, but aberrant spindle…
View article: O-150 Cumulative live birth rates of 31 478 untested embryos from 11 463 women challenge traditional RIF definitions
O-150 Cumulative live birth rates of 31 478 untested embryos from 11 463 women challenge traditional RIF definitions Open
Study question Is there evidence of a plateau in the cumulative live birth rate after a certain number of consecutive transfers of untested embryos? Summary answer In 11 463 women, cumulative live birth rates increased with each additional…
View article: O-149 No effect of maternal age on embryo implantation and live birth rates after preimplantation genetic testing for aneuploidies: retrospective analysis of 11,855 single blastocyst transfers
O-149 No effect of maternal age on embryo implantation and live birth rates after preimplantation genetic testing for aneuploidies: retrospective analysis of 11,855 single blastocyst transfers Open
Study question Does advanced maternal age affect clinical outcomes after euploid embryo transfer? Summary answer Advanced maternal age does not significantly affect clinical outcomes after euploid embryo transfer but is associated with poo…
View article: O-294 Spindle transfer rescues impaired fertilization linked to Patl2-mediated dysregulation of maternal mRNA translation
O-294 Spindle transfer rescues impaired fertilization linked to Patl2-mediated dysregulation of maternal mRNA translation Open
Study question Can single-cell, mass spectrometry-based proteomics reveal proteins underlying the reduced fertilizing capacity of Patl2-/- MII mouse oocytes? Is it possible to treat Patl2-related infertility? Summary answer Reduced protein…
View article: P-543 Transdermal testosterone and quality of life in women with diminished ovarian reserve: secondary analysis of a triple-blind randomised controlled trial
P-543 Transdermal testosterone and quality of life in women with diminished ovarian reserve: secondary analysis of a triple-blind randomised controlled trial Open
Study question What factors influence fertility-associated quality of life (QOL) in women with diminished ovarian reserve (DOR), and does testosterone improve QOL in this population? Summary answer Several factors are associated with QOL i…
View article: P-804 Improving CRISPR/Cas9 gene correction in early mouse embryos using RNase-resistant crRNA XT
P-804 Improving CRISPR/Cas9 gene correction in early mouse embryos using RNase-resistant crRNA XT Open
Study question How can we improve the safety and efficiency of germline gene correction using CRISPR/Cas9 in early mouse embryos? Summary answer We observed a higher frequency of desirable gene editing events when using crRNA XT for CRISPR…
View article: Biphasic CAPA-IVM Improves Equine Oocyte Quality and Subsequent Embryo Development Without Inducing Genetic Aberrations
Biphasic CAPA-IVM Improves Equine Oocyte Quality and Subsequent Embryo Development Without Inducing Genetic Aberrations Open
In vitro maturation (IVM) of oocytes retrieved from ovum pick-up (OPU) or ovarian tissue (OT) is a standard approach for patients with specific conditions where prior hormonal stimulation is contraindicated. However, the developmental comp…
View article: Various repair events following CRISPR/Cas9-based mutational correction of an infertility-related mutation in mouse embryos
Various repair events following CRISPR/Cas9-based mutational correction of an infertility-related mutation in mouse embryos Open
View article: Pronuclear transfer rescues poor embryo development of <i>in vitro</i>-grown secondary mouse follicles
Pronuclear transfer rescues poor embryo development of <i>in vitro</i>-grown secondary mouse follicles Open
STUDY QUESTION Is pronuclear transfer (PNT) capable of restoring embryo developmental arrest caused by cytoplasmic inferiority of in vitro-grown (IVG) mouse oocytes? SUMMARY ANSWER PNT to in vivo matured cytoplasm significantly improved em…
View article: High rate of detected variants in male <i>PLCZ1</i> and <i>ACTL7A</i> genes causing failed fertilization after ICSI
High rate of detected variants in male <i>PLCZ1</i> and <i>ACTL7A</i> genes causing failed fertilization after ICSI Open
STUDY QUESTION What is the frequency of PLCZ1, ACTL7A, and ACTL9 variants in male patients showing fertilization failure after ICSI, and how effective is assisted oocyte activation (AOA) for them? SUMMARY ANSWER Male patients with fertiliz…
View article: Aligning genotyping and copy number data in single trophectoderm biopsies for aneuploidy prediction: uncovering incomplete concordance
Aligning genotyping and copy number data in single trophectoderm biopsies for aneuploidy prediction: uncovering incomplete concordance Open
STUDY QUESTION To what extent can genotype analysis aid in the classification of (mosaic) aneuploid embryos diagnosed through copy number analysis of a trophectoderm (TE) biopsy? SUMMARY ANSWER In a small portion of embryos, genotype analy…
View article: Translation of the Modified Polycystic Ovary Syndrome Questionnaire (mPCOSQ) and the Polycystic Ovary Syndrome Quality of Life Tool (PCOSQOL) in Dutch and Flemish Women with PCOS
Translation of the Modified Polycystic Ovary Syndrome Questionnaire (mPCOSQ) and the Polycystic Ovary Syndrome Quality of Life Tool (PCOSQOL) in Dutch and Flemish Women with PCOS Open
This study aims to determine the test–retest reliability and to confirm the domain structures of the Dutch version of the modified polycystic ovary syndrome questionnaire (mPCOSQ) and the Polycystic Ovary Syndrome Quality of Life Scale (PC…
View article: P-431 Effect of biphasic CAPA-IVM on ovarian tissue oocytes of transgender men
P-431 Effect of biphasic CAPA-IVM on ovarian tissue oocytes of transgender men Open
Study question Can CAPA-IVM (Biphasic in-vitro maturation) with C-type natriuretic peptide (CNP), followed by in vitro maturation (IVM) improve ovarian tissue oocyte (OTO) maturation in transgender patients? Summary answer Biphasic CAPA-IV…
View article: Live birth rate per transfer is not impacted by the proportion of smooth endoplasmatic reticulum aggregates oocytes
Live birth rate per transfer is not impacted by the proportion of smooth endoplasmatic reticulum aggregates oocytes Open
Background: Despite the data published to date, prognostic factors and the clinical impact of ICSI cycles with smooth endoplasmatic reticulum aggregates (SERa) positive oocytes remain unclear. Objective: Are the clinical outcomes of an ICS…
View article: P-740 Monogenic and digenic variants in male PLCZ1, ACTL7A and ACTL9 genes cause fertilization failure after ICSI
P-740 Monogenic and digenic variants in male PLCZ1, ACTL7A and ACTL9 genes cause fertilization failure after ICSI Open
Study question What is the frequency of PLCZ1, ACTL7A and ACTL9 variants in male patients suffering from fertilization failure (FF) after ICSI? Summary answer Male patients with FF after ICSI exhibit variants in PLCZ1 (27,3%), ACTL7A (13,6…
View article: P-569 Unraveling parenthood intentions of 1700 adolescents in 2022, Flanders (Belgium)
P-569 Unraveling parenthood intentions of 1700 adolescents in 2022, Flanders (Belgium) Open
Study question What are the current attitudes in Flemish adolescents aged 15-19 towards having children? Summary answer While the majority of adolescents want to have children, 25% have ambiguous feelings about having children and 10% indi…
View article: P-802 TFAP2C is required for proper segregation of developmental markers regulating trophectoderm commitment during mouse preimplantation development
P-802 TFAP2C is required for proper segregation of developmental markers regulating trophectoderm commitment during mouse preimplantation development Open
Study question What is the effect of CRISPR/Cas9-mediated knock-out of trophectoderm markers TFAP2A/C on polarization and lineage commitment in mouse? Summary answer CRISPR/Cas9-mediated KO revealed discrepancies in TFAP2A/C function, wher…