Dominik Meier
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View article: Extended Technical and Clinical Validation of Deep Learning‐Based Brainstem Segmentation for Application in Neurodegenerative Diseases
Extended Technical and Clinical Validation of Deep Learning‐Based Brainstem Segmentation for Application in Neurodegenerative Diseases Open
Disorders of the central nervous system, including neurodegenerative diseases, frequently affect the brainstem and can present with focal atrophy. This study aimed to (1) optimize deep learning‐based brainstem segmentation for a wide range…
View article: Technical and clinical validation of a novel deep learning-based white matter hyperintensity segmentation tool
Technical and clinical validation of a novel deep learning-based white matter hyperintensity segmentation tool Open
We developed and systematically validated two novel WMH segmentation algorithms, which demonstrated excellent generalization capabilities. The comprehensive, user-friendly processing pipelines are publicly available as prebuilt software co…
View article: Using novel data and ensemble models to improve automated labeling of Sustainable Development Goals
Using novel data and ensemble models to improve automated labeling of Sustainable Development Goals Open
A number of labeling systems based on text have been proposed to help monitor work on the United Nations (UN) Sustainable Development Goals (SDGs). Here, we present a systematic comparison of systems using a variety of text sources and sho…
View article: Paramagnetic rims are a promising diagnostic imaging biomarker in multiple sclerosis
Paramagnetic rims are a promising diagnostic imaging biomarker in multiple sclerosis Open
Background: White matter lesions (WMLs) on brain magnetic resonance imaging (MRI) in multiple sclerosis (MS) may contribute to misdiagnosis. In chronic active lesions, peripheral iron-laden macrophages appear as paramagnetic rim lesions (P…
View article: Trusscillator: a System for Fabricating Human-Scale Human-Powered Oscillating Devices
Trusscillator: a System for Fabricating Human-Scale Human-Powered Oscillating Devices Open
Trusscillator is an end-to-end system that allows non-engineers to create human-scale human-powered devices that perform oscillatory movements, such as playground equipment, workout devices, and interactive kinetic installations. While rec…
View article: Risk Preferences and Risk Perception Affect the Acceptance of Digital Contact Tracing
Risk Preferences and Risk Perception Affect the Acceptance of Digital Contact Tracing Open
Digital contact-tracing applications (DCTAs) can control the spread of epidemics, like the COVID-19 pandemic. But people in Western societies fail to accept DCTAs. Understanding the low acceptance is key to policymakers who support DCTAs t…
View article: A contrast-adaptive method for simultaneous whole-brain and lesion segmentation in multiple sclerosis
A contrast-adaptive method for simultaneous whole-brain and lesion segmentation in multiple sclerosis Open
Here we present a method for the simultaneous segmentation of white matter lesions and normal-appearing neuroanatomical structures from multi-contrast brain MRI scans of multiple sclerosis patients. The method integrates a novel model for …
View article: Evaluation of the ‘ring sign’ and the ‘core sign’ as a magnetic resonance imaging marker of disease activity and progression in clinically isolated syndrome and early multiple sclerosis
Evaluation of the ‘ring sign’ and the ‘core sign’ as a magnetic resonance imaging marker of disease activity and progression in clinically isolated syndrome and early multiple sclerosis Open
Background Brain lesions with a hypointense ring or core were described in multiple sclerosis on susceptibility weighted imaging. Objective The purpose of this study was to study the evolution and prognostic relevance of susceptibility wei…
View article: Evaluation of the Central Vein Sign as a Diagnostic Imaging Biomarker in Multiple Sclerosis
Evaluation of the Central Vein Sign as a Diagnostic Imaging Biomarker in Multiple Sclerosis Open
In this study, use of the central vein sign at 3T MRI yielded a high specificity and a moderate sensitivity in differentiating MS from not MS; international, multicenter studies may be needed to ascertain whether the central vein sign-base…
View article: Accurate, rapid and reliable, fully automated MRI brainstem segmentation for application in multiple sclerosis and neurodegenerative diseases
Accurate, rapid and reliable, fully automated MRI brainstem segmentation for application in multiple sclerosis and neurodegenerative diseases Open
Neurodegenerative disorders, such as Alzheimer's disease (AD) and progressive forms of multiple sclerosis (MS), can affect the brainstem and are associated with atrophy that can be visualized by MRI. Anatomically accurate, large‐scale asse…
Longitudinal microstructural changes of cerebral white matter and their association with mobility performance in older persons Open
Mobility impairment in older persons is associated with brain white matter hyperintensities (WMH), a common finding in magnetic resonance images and one established imaging biomarker of small vessel disease. The contribution of possible mi…
View article: Dual‐Sensitivity Multiple Sclerosis Lesion and CSF Segmentation for Multichannel 3T Brain MRI
Dual‐Sensitivity Multiple Sclerosis Lesion and CSF Segmentation for Multichannel 3T Brain MRI Open
BACKGROUND AND PURPOSE A pipeline for fully automated segmentation of 3T brain MRI scans in multiple sclerosis (MS) is presented. This 3T morphometry (3TM) pipeline provides indicators of MS disease progression from multichannel datasets w…
View article: Longitudinal diffusion changes following postoperative delirium in older people without dementia
Longitudinal diffusion changes following postoperative delirium in older people without dementia Open
Our study raises the possibility that delirium has an effect on the development of brain microstructural abnormalities, which may reflect brain changes underlying cognitive trajectories. Future studies are warranted to clarify whether deli…
View article: Posterior lobules of the cerebellum and information processing speed at various stages of multiple sclerosis
Posterior lobules of the cerebellum and information processing speed at various stages of multiple sclerosis Open
Clinicaltrail NCT01207856, NCT01865357; Pre-results.
View article: Cerebral blood flow MRI in the nondemented elderly is not predictive of post-operative delirium but is correlated with cognitive performance
Cerebral blood flow MRI in the nondemented elderly is not predictive of post-operative delirium but is correlated with cognitive performance Open
Three-dimensional Arterial Spin Labeling (ASL) MRI was performed before surgery in a cohort of 146 prospectively enrolled subjects ≥ 70 years old scheduled to undergo elective surgery. We investigated the prospective association between AS…
View article: Neural substrates of vulnerability to postsurgical delirium as revealed by presurgical diffusion MRI
Neural substrates of vulnerability to postsurgical delirium as revealed by presurgical diffusion MRI Open
Despite the significant impact of postoperative delirium on surgical outcomes and the long-term prognosis of older patients, its neural basis has not yet been clarified. In this study we investigated the impact of premorbid brain microstru…
View article: Memory impairment in multiple sclerosis: Relevance of hippocampal activation and hippocampal connectivity
Memory impairment in multiple sclerosis: Relevance of hippocampal activation and hippocampal connectivity Open
Background: Memory impairment is frequent in multiple sclerosis (MS), but it is unclear what functional brain changes underlie this cognitive deterioration. Objective: To investigate functional hippocampal activation and connectivity, in r…