Dominik Pesta
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View article: Daily use of countermeasures to prevent headward fluid shifts throughout 30 days of strict head-down tilt bed rest
Daily use of countermeasures to prevent headward fluid shifts throughout 30 days of strict head-down tilt bed rest Open
We demonstrate that daily use of lower body negative pressure or venoconstrictive thigh cuffs following aerobic exercise is well tolerated throughout 30 days of exposure to the spaceflight analog strict head-down tilt bed rest. Both counte…
View article: Post‐<scp>COVID</scp>‐19 Condition in Track and Field Master Athletes: Severity, Symptoms, and Associations With Quality of Life and C‐Reactive Protein Levels
Post‐<span>COVID</span>‐19 Condition in Track and Field Master Athletes: Severity, Symptoms, and Associations With Quality of Life and C‐Reactive Protein Levels Open
Here, we assessed the prevalence of post‐COVID‐condition (PCC, also known as long‐COVID) and investigated its associations with health‐related quality of life and immune‐related biomarkers in track and field masters athletes (MAs). A total…
View article: In Memory of Professor Dr. med. Jörn Rittweger
In Memory of Professor Dr. med. Jörn Rittweger Open
View article: Mechanical countermeasures for spaceflight-associated neuro-ocular syndrome during 30-days of head down tilt bed rest: design, implementation, and tolerability
Mechanical countermeasures for spaceflight-associated neuro-ocular syndrome during 30-days of head down tilt bed rest: design, implementation, and tolerability Open
After longer duration space missions, some astronauts experience structural and functional changes in the eye and structural changes in the brain, termed Spaceflight-Associated Neuro-Ocular Syndrome (SANS). Countermeasures against SANS are…
View article: A Randomized Control Trial Investigating the Effect of Different Treatment Strategies on Mitochondrial Function in Peripheral Arterial Disease: A Study Protocol
A Randomized Control Trial Investigating the Effect of Different Treatment Strategies on Mitochondrial Function in Peripheral Arterial Disease: A Study Protocol Open
Peripheral arterial disease encompasses different clinical symptoms, depending on the severity of the disease. In early stages, a walking-induced pain, known as intermittent claudication, is the leading clinical symptom. Repeating cycles o…
View article: Influence of Ambient Temperature on Resting Energy Expenditure in Metabolically Healthy Males and Females
Influence of Ambient Temperature on Resting Energy Expenditure in Metabolically Healthy Males and Females Open
View article: Determinants of increased muscle insulin sensitivity of exercise-trained versus sedentary normal weight and overweight individuals
Determinants of increased muscle insulin sensitivity of exercise-trained versus sedentary normal weight and overweight individuals Open
The athlete’s paradox states that intramyocellular triglyceride accumulation associates with insulin resistance in sedentary but not in endurance-trained humans. Underlying mechanisms and the role of muscle lipid distribution and compositi…
View article: Loss of atrial natriuretic peptide signaling causes insulin resistance, mitochondrial dysfunction, and low endurance capacity
Loss of atrial natriuretic peptide signaling causes insulin resistance, mitochondrial dysfunction, and low endurance capacity Open
Type 2 diabetes (T2D) and obesity are strongly associated with low natriuretic peptide (NP) plasma levels and a down-regulation of NP guanylyl cyclase receptor-A (GCA) in skeletal muscle and adipose tissue. However, no study has so far pro…
View article: Physical activity and cardiometabolic risk factors in sprint and jump-trained masters athletes, young athletes and non-physically active men
Physical activity and cardiometabolic risk factors in sprint and jump-trained masters athletes, young athletes and non-physically active men Open
Objectives Assessing physical activity and cardiometabolic risk in masters athletes as an example of very high physical activity at old age. Methods Forty-three men were studied in full factorial design, either as sprint or jump-trained ma…
View article: Harmonization of experimental procedures to assess mitochondrial respiration in human permeabilized skeletal muscle fibers
Harmonization of experimental procedures to assess mitochondrial respiration in human permeabilized skeletal muscle fibers Open
Our study constitutes a basis to harmonize and establish optimum experimental conditions for respirometric studies of permeabilized human skeletal muscle fibers to improve reproducibility.
View article: Mitochondrial respiration in peripheral arterial disease depends on stage severity
Mitochondrial respiration in peripheral arterial disease depends on stage severity Open
Peripheral arterial disease (PAD) is an increasing cause of morbidity and its severity is graded based on clinical manifestation. To investigate the influence of the different stages on myopathy of ischemic muscle we analysed severity‐depe…
View article: Immortalised murine R349P desmin knock-in myotubes exhibit a reduced proton leak and decreased ADP/ATP translocase levels in purified mitochondria
Immortalised murine R349P desmin knock-in myotubes exhibit a reduced proton leak and decreased ADP/ATP translocase levels in purified mitochondria Open
Desmin gene mutations cause myopathies and cardiomyopathies. Our previously characterised R349P desminopathy mice, which carry the ortholog of the common human desmin mutation R350P, showed marked alterations in mitochondrial morphology an…
View article: Dietary Intake of Athletes at the World Masters Athletics Championships as Assessed by Single 24 h Recall
Dietary Intake of Athletes at the World Masters Athletics Championships as Assessed by Single 24 h Recall Open
Proper dietary intake is important for masters athletes because of the physiological changes that occur with aging and the unique nutritional needs when competing at high levels. We evaluated the dietary intake of masters athletes competin…
View article: Effects of 30 days bed rest and exercise countermeasures on <scp>PBMC</scp> bioenergetics
Effects of 30 days bed rest and exercise countermeasures on <span>PBMC</span> bioenergetics Open
Aim Altered mitochondrial function across various tissues is a key determinant of spaceflight‐induced physical deconditioning. In comparison to tissue biopsies, blood cell bioenergetics holds promise as a systemic and more readily accessib…
View article: Immortalised murine R349P desmin knock-in myotubes exhibit a reduced proton leak and decreased ADP/ATP translocase levels in purified mitochondria
Immortalised murine R349P desmin knock-in myotubes exhibit a reduced proton leak and decreased ADP/ATP translocase levels in purified mitochondria Open
Desmin gene mutations cause myopathies and cardiomyopathies. Our previously characterised R349P desminopathy mice, which carry the ortholog of the common human desmin mutation R350P, showed marked alterations in mitochondrial morphology an…
View article: Impact of physical fitness and exercise training on subcutaneous adipose tissue beiging markers in humans with and without diabetes and a high‐fat diet‐fed mouse model
Impact of physical fitness and exercise training on subcutaneous adipose tissue beiging markers in humans with and without diabetes and a high‐fat diet‐fed mouse model Open
Aims Exercise training induces white adipose tissue (WAT) beiging and improves glucose homeostasis and mitochondrial function in rodents. This could be relevant for type 2 diabetes in humans, but the effect of physical fitness on beiging o…
View article: Oral fructose intake does not improve exercise, visual, or cognitive performance during acute normobaric hypoxia in healthy humans
Oral fructose intake does not improve exercise, visual, or cognitive performance during acute normobaric hypoxia in healthy humans Open
Introduction The ability to metabolize fructose to bypass the glucose pathway in near-anaerobic conditions appears to contribute to the extreme hypoxia tolerance of the naked-mole rats. Therefore, we hypothesized that exogenous fructose co…
View article: Alterations of hepatic energy metabolism in murine models of obesity, diabetes and fatty liver diseases
Alterations of hepatic energy metabolism in murine models of obesity, diabetes and fatty liver diseases Open
Funding bodies that contributed to this study were listed in the acknowledgements section.
View article: Loss of mitochondrial adaptation associates with deterioration of mitochondrial turnover and structure in obesity-related fatty liver disease
Loss of mitochondrial adaptation associates with deterioration of mitochondrial turnover and structure in obesity-related fatty liver disease Open
Background Obesity and type 2 diabetes feature higher prevalence of non-alcoholic fatty liver (NAFL) and steatohepatitis (NASH). In obesity-related insulin resistance, the liver may adapt its oxidative capacity, but the role of mitochondri…
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Contents Open
View article: Macronutrient composition and metabolic regulation: Do our islets care what we eat?
Macronutrient composition and metabolic regulation: Do our islets care what we eat? Open
The study by Klinsmann et al. in this issue investigated effects of macronutrients, particularly carbohydrates and fat, on the insulin-to-glucagon ratio in vitro and in vivo.1 Furthermore, the authors tested whether this ratio is altered i…
View article: Mitochondrial respiration is decreased in visceral but not subcutaneous adipose tissue in obese individuals with fatty liver disease
Mitochondrial respiration is decreased in visceral but not subcutaneous adipose tissue in obese individuals with fatty liver disease Open
View article: Comparison of trunk muscle exercises in supine position during short arm centrifugation with 1 g at centre of mass and upright in 1 g
Comparison of trunk muscle exercises in supine position during short arm centrifugation with 1 g at centre of mass and upright in 1 g Open
Spaceflight is associated with reduced antigravitational muscle activity, which results in trunk muscle atrophy and may contribute to post-flight postural and spinal instability. Exercise in artificial gravity (AG) performed via short-arm …
View article: Author Correction: Dynamic changes of muscle insulin sensitivity after metabolic surgery
Author Correction: Dynamic changes of muscle insulin sensitivity after metabolic surgery Open
View article: Dietary lipid droplet structure in postnatal life improves hepatic energy and lipid metabolism in a mouse model for postnatal programming
Dietary lipid droplet structure in postnatal life improves hepatic energy and lipid metabolism in a mouse model for postnatal programming Open
View article: INDY as a Therapeutic Target for Cardio-Metabolic Disease
INDY as a Therapeutic Target for Cardio-Metabolic Disease Open
Decreased expression of the plasma membrane citrate transporter INDY (acronym I’m Not Dead, Yet) promotes longevity and protects from high-fat diet- and aging-induced metabolic derangements. Preventing citrate import into hepatocytes by di…
View article: High-intensity interval training for 12 weeks improves cardiovascular autonomic function but not somatosensory nerve function and structure in overweight men with type 2 diabetes
High-intensity interval training for 12 weeks improves cardiovascular autonomic function but not somatosensory nerve function and structure in overweight men with type 2 diabetes Open
View article: Impaired Hepatic Mitochondrial Capacity in Nonalcoholic Steatohepatitis Associated With Type 2 Diabetes
Impaired Hepatic Mitochondrial Capacity in Nonalcoholic Steatohepatitis Associated With Type 2 Diabetes Open
Objective: Persons with type 2 diabetes are at higher risk of progression of non-alcoholic fatty liver (steatosis) to steatohepatitis (NASH), fibrosis and cirrhosis. Obese humans adapt their hepatic metabolism by upregulation of mit…
View article: Impaired Hepatic Mitochondrial Capacity in Nonalcoholic Steatohepatitis Associated With Type 2 Diabetes
Impaired Hepatic Mitochondrial Capacity in Nonalcoholic Steatohepatitis Associated With Type 2 Diabetes Open
Objective: Persons with type 2 diabetes are at higher risk of progression of non-alcoholic fatty liver (steatosis) to steatohepatitis (NASH), fibrosis and cirrhosis. Obese humans adapt their hepatic metabolism by upregulation of mit…
View article: Impaired Hepatic Mitochondrial Capacity in Nonalcoholic Steatohepatitis Associated With Type 2 Diabetes
Impaired Hepatic Mitochondrial Capacity in Nonalcoholic Steatohepatitis Associated With Type 2 Diabetes Open
OBJECTIVE Individuals with type 2 diabetes are at higher risk of progression of nonalcoholic fatty liver (steatosis) to steatohepatitis (NASH), fibrosis, and cirrhosis. The hepatic metabolism of obese individuals adapts by upregulation of …