Dominique Costagliola
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View article: Impacts of immune checkpoint inhibitors use on the HIV reservoir are linked to provirus sequences but not integration sites
Impacts of immune checkpoint inhibitors use on the HIV reservoir are linked to provirus sequences but not integration sites Open
View article: Differences between men who have sex with men that use drugs and engage in chemsex and those who do not engage in chemsex in the French ANRS-PREVENIR cohort: the need to rethink harm reduction services
Differences between men who have sex with men that use drugs and engage in chemsex and those who do not engage in chemsex in the French ANRS-PREVENIR cohort: the need to rethink harm reduction services Open
View article: Effects of Janus kinase inhibitors in adults admitted to hospital due to COVID-19: a systematic review and individual participant data meta-analysis of randomised clinical trials
Effects of Janus kinase inhibitors in adults admitted to hospital due to COVID-19: a systematic review and individual participant data meta-analysis of randomised clinical trials Open
This project has received funding from the EU's Horizon 2020 research and innovation programme under grant agreement number 101015736.
View article: Correction to “Impact of vaccination with third generation modified vaccinia Ankara and sexual behaviour on mpox incidence in men who have sex with men: analysis among participants of the ANRS-174 DOXYVAC trial” [The Lancet Regional Health—Europe 45, October 2024, 101020]
Correction to “Impact of vaccination with third generation modified vaccinia Ankara and sexual behaviour on mpox incidence in men who have sex with men: analysis among participants of the ANRS-174 DOXYVAC trial” [The Lancet Regional Health—Europe 45, October 2024, 101020] Open
View article: Impact of rosuvastatin on the memory potential and functionality of CD8+ T cells from people with HIV
Impact of rosuvastatin on the memory potential and functionality of CD8+ T cells from people with HIV Open
View article: Harmonization of alcohol use data and mortality across a multi‐national <scp>HIV</scp> cohort collaboration
Harmonization of alcohol use data and mortality across a multi‐national <span>HIV</span> cohort collaboration Open
Background Alcohol use is measured in diverse ways across settings. Harmonization of measures is necessary to assess effects of alcohol use in multi‐cohort collaborations, such as studies of people with HIV (PWH). Methods Data were combine…
View article: Safety of baricitinib in vaccinated patients with severe and critical COVID-19 sub study of the randomised Bari-SolidAct trial
Safety of baricitinib in vaccinated patients with severe and critical COVID-19 sub study of the randomised Bari-SolidAct trial Open
View article: Open Letter: Confronting the IHU Scandal – The Need for Deep Reforms and Decisive Action
Open Letter: Confronting the IHU Scandal – The Need for Deep Reforms and Decisive Action Open
We, as scientists, doctors, or concerned citizens, demand the establishment of an independent scientific inquiry commission to evaluate these breaches and determine the necessary actions. At a minimum, we hope that those responsible for th…
View article: Engagement in Preexposure Prophylaxis Care at 1 Year Among Men Who Have Sex With Men Enrolled in the French ANRS PREVENIR Cohort Study
Engagement in Preexposure Prophylaxis Care at 1 Year Among Men Who Have Sex With Men Enrolled in the French ANRS PREVENIR Cohort Study Open
Background We evaluated 1-year engagement in pre-exposure prophylaxis (PrEP) care and associated factors among gay, bisexual, and other men who have sex with men (GBMSM) in a large cohort of oral PrEP users in the Paris region, France. Met…
View article: Immune reconstitution and evolution of B-cell–stimulating cytokines after R-CHOP therapy for HIV-associated DLBCL
Immune reconstitution and evolution of B-cell–stimulating cytokines after R-CHOP therapy for HIV-associated DLBCL Open
HIV infection is associated with an increased risk of diffuse large B-cell lymphoma (DLBCL). In this prospective study, we analyzed the evolution of B-cell activating cytokines (interleukin-6 [IL-6], IL-10, and B-cell activating factor [BA…
View article: Safety and tolerability of immune checkpoint inhibitors in people with HIV infection and cancer: insights from the national prospective real-world OncoVIHAC ANRS CO24 cohort study
Safety and tolerability of immune checkpoint inhibitors in people with HIV infection and cancer: insights from the national prospective real-world OncoVIHAC ANRS CO24 cohort study Open
Background Immune checkpoint inhibitors (ICIs) have been a major advance in cancer management. However, we still lack prospective real-world data regarding their usage in people with HIV infection (PWH). Methods The ANRS CO24 OncoVIHAC stu…
View article: Impact of vaccination with third generation modified vaccinia Ankara and sexual behaviour on mpox incidence in men who have sex with men: analysis among participants of the ANRS-174 DOXYVAC trial
Impact of vaccination with third generation modified vaccinia Ankara and sexual behaviour on mpox incidence in men who have sex with men: analysis among participants of the ANRS-174 DOXYVAC trial Open
View article: Cardiac Adverse Events and Remdesivir in Hospitalized Patients With COVID-19: A Post Hoc Safety Analysis of the Randomized DisCoVeRy Trial
Cardiac Adverse Events and Remdesivir in Hospitalized Patients With COVID-19: A Post Hoc Safety Analysis of the Randomized DisCoVeRy Trial Open
Background We aimed to evaluate the cardiac adverse events (AEs) in hospitalized patients with coronavirus disease 2019 (COVID-19) who received remdesivir plus standard of care (SoC) compared with SoC alone (control), as an association was…
View article: Tixagevimab-cilgavimab (AZD7442) for the treatment of patients hospitalized with COVID-19 (DisCoVeRy): A phase 3, randomized, double-blind, placebo-controlled trial
Tixagevimab-cilgavimab (AZD7442) for the treatment of patients hospitalized with COVID-19 (DisCoVeRy): A phase 3, randomized, double-blind, placebo-controlled trial Open
View article: Safety of Baricitinib in Vaccinated Patients with Severe and Critical COVID-19. Sub Study of the Randomised Bari-SolidAct Trial
Safety of Baricitinib in Vaccinated Patients with Severe and Critical COVID-19. Sub Study of the Randomised Bari-SolidAct Trial Open
View article: Effects of Jak Inhibitors in Adults Hospitalized Due to Covid-19: A Systematic Review and Individual Participant Data Meta-Analysis of Randomized Clinical Trials
Effects of Jak Inhibitors in Adults Hospitalized Due to Covid-19: A Systematic Review and Individual Participant Data Meta-Analysis of Randomized Clinical Trials Open
View article: Ex-vivo rectal tissue infection with HIV-1 to assess time to protection following oral preexposure prophylaxis with tenofovir disoproxil/emtricitabine
Ex-vivo rectal tissue infection with HIV-1 to assess time to protection following oral preexposure prophylaxis with tenofovir disoproxil/emtricitabine Open
Objectives: We wished to assess time to protection from HIV-1 infection following oral tenofovir disoproxil and emtricitabine (TDF/FTC) as preexposure prophylaxis (PrEP), using ex-vivo rectal tissue infections and drug concentration measur…
View article: Association between SARS‐CoV‐2 viral kinetics and clinical score evolution in hospitalized patients
Association between SARS‐CoV‐2 viral kinetics and clinical score evolution in hospitalized patients Open
The role of antiviral treatment in coronavirus disease 2019 hospitalized patients is controversial. To address this question, we analyzed simultaneously nasopharyngeal viral load and the National Early Warning Score 2 (NEWS‐2) using an eff…
View article: Brentuximab vedotin with AVD for stage II–IV HIV-related Hodgkin lymphoma (AMC 085): phase 2 results from an open-label, single arm, multicentre phase 1/2 trial
Brentuximab vedotin with AVD for stage II–IV HIV-related Hodgkin lymphoma (AMC 085): phase 2 results from an open-label, single arm, multicentre phase 1/2 trial Open
View article: Latent Tuberculosis Infection and Associated Risk Factors among People Living with HIV and HIV-Uninfected Individuals in Lithuania
Latent Tuberculosis Infection and Associated Risk Factors among People Living with HIV and HIV-Uninfected Individuals in Lithuania Open
Background: People living with HIV (PLHIV) with latent tuberculosis infection (LTBI) are at increased risk of tuberculosis (TB) reactivation compared to the HIV-negative population. Lithuania belongs to the 18 high-priority TB countries in…
View article: Management of pharmacovigilance during the <scp>COVID</scp>‐19 pandemic crisis by the safety department of an academic sponsor: Lessons learnt and challenges from the <scp>EU DisCoVeRy</scp> clinical trial
Management of pharmacovigilance during the <span>COVID</span>‐19 pandemic crisis by the safety department of an academic sponsor: Lessons learnt and challenges from the <span>EU DisCoVeRy</span> clinical trial Open
The current COVID‐19 pandemic was an exceptional health situation, including for drug use. As there was no known effective drug for COVID‐19 at the beginning of the pandemic, different drug candidates were proposed. In this article, we pre…
View article: No time for complacency on COVID-19 in Europe
No time for complacency on COVID-19 in Europe Open
View article: Cardiovascular Diseases and Exposure to Integrase Inhibitors: Causal Interpretation of Treatment Effect in Observational Studies
Cardiovascular Diseases and Exposure to Integrase Inhibitors: Causal Interpretation of Treatment Effect in Observational Studies Open
View article: Perception of <scp>PrEP</scp>‐related stigma in <scp>PrEP</scp> users: Results from the <scp>ANRS‐PREVENIR</scp> cohort
Perception of <span>PrEP</span>‐related stigma in <span>PrEP</span> users: Results from the <span>ANRS‐PREVENIR</span> cohort Open
Introduction Since the advent of HIV pre‐exposure prophylaxis (PrEP), stigma has been shown to be a major barrier to its uptake and adherence. It is therefore essential to define the proportion of users who consider that PrEP can negativel…
View article: Mortality in hepatitis C virus-cured vs. hepatitis C virus-uninfected people with HIV
Mortality in hepatitis C virus-cured vs. hepatitis C virus-uninfected people with HIV Open
Objective: It is unknown whether hepatitis C virus (HCV)-cured people with HIV (PWH) without cirrhosis reached the same mortality risk as HCV-uninfected PWH. We aimed to compare mortality in PWH cured of HCV by direct-acting antivirals (DA…
View article: The socio-demographic, clinical characteristics and outcomes of tuberculosis among HIV infected adults in Lithuania: A thirteen-year analysis
The socio-demographic, clinical characteristics and outcomes of tuberculosis among HIV infected adults in Lithuania: A thirteen-year analysis Open
Background Tuberculosis (TB) is a public health problem in Lithuania, among the 18 high-priority TB countries in the European region, and the most common AIDS-indicative disease with the highest proportion in the EU/EEA since 2015. The stu…
View article: Effects of remdesivir in patients hospitalised with COVID-19: a systematic review and individual patient data meta-analysis of randomised controlled trials
Effects of remdesivir in patients hospitalised with COVID-19: a systematic review and individual patient data meta-analysis of randomised controlled trials Open
View article: Rapid access to innovative medicinal products while ensuring relevant health technology assessment. Position of the French National Authority for Health
Rapid access to innovative medicinal products while ensuring relevant health technology assessment. Position of the French National Authority for Health Open
International audience
View article: Striking differences in weight gain after cART initiation depending on early or advanced presentation: results from the ANRS CO4 FHDH cohort
Striking differences in weight gain after cART initiation depending on early or advanced presentation: results from the ANRS CO4 FHDH cohort Open
Background Many studies have reported weight gain in ART-naive people living with HIV (PWH) initiating an integrase strand-transfer inhibitor-based regimen. We studied the impact of early or advanced presentation and that of individual dru…
View article: Implementation of a centralized pharmacovigilance system in academic pan‐European clinical trials: Experience from EU‐Response and conect4children consortia
Implementation of a centralized pharmacovigilance system in academic pan‐European clinical trials: Experience from EU‐Response and conect4children consortia Open
Setting‐up a high quality, compliant and efficient pharmacovigilance (PV) system in multi‐country clinical trials can be more challenging for academic sponsors than for companies. To ensure the safety of all participants in academic studie…