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View article: Analysis of Posttraumatic Stress Disorder Gene Expression Profiles in a Prospective, Community-Based Cohort
Analysis of Posttraumatic Stress Disorder Gene Expression Profiles in a Prospective, Community-Based Cohort Open
Posttraumatic stress disorder (PTSD) is a common and debilitating psychiatric disorder that may occur in individuals exposed to traumatic events such as accidents, interpersonal violence, war, combat, or natural disasters. Additionally, PT…
View article: Analysis of Post-traumatic Stress Disorder Gene Expression Profiles in a Prospective, Community-based Cohort
Analysis of Post-traumatic Stress Disorder Gene Expression Profiles in a Prospective, Community-based Cohort Open
Post-traumatic stress disorder (PTSD) is a common and debilitating psychiatric disorder that may occur in individuals exposed to traumatic events such as accidents, interpersonal violence, war, combat, or natural disasters. Additionally, P…
View article: Additional file 1 of Associations between childhood family emotional health, fronto-limbic grey matter volume, and saliva 5mC in young adulthood
Additional file 1 of Associations between childhood family emotional health, fronto-limbic grey matter volume, and saliva 5mC in young adulthood Open
Additional file 1: Supplementary Tables. Table S1. FEH predicts MEs. Table S2. MEs predict BRV. Table S3. Probe specific annotations. Table S4. Probe-wise mediation. Table S5. Condensed GSEA. Table S6. Cohort-level mental health diagnoses.…
View article: Transcriptomic profiling of fetal membranes of mice deficient in biglycan and decorin as a model of preterm birth†
Transcriptomic profiling of fetal membranes of mice deficient in biglycan and decorin as a model of preterm birth† Open
Approximately, 25% of all preterm births are due to preterm premature rupture of membranes. Mice deficient in proteoglycans biglycan (Bgn) and decorin (Dcn) display abnormal fetal membranes and increased incidence of preterm birth. We cond…
View article: Associations between childhood family emotional health, fronto-limbic grey matter volume, and saliva 5mC in young adulthood
Associations between childhood family emotional health, fronto-limbic grey matter volume, and saliva 5mC in young adulthood Open
Background Poor family emotional health (FEH) during childhood is prevalent and impactful, and likely confers similar neurodevelopmental risks as other adverse social environments. Pointed FEH study efforts are underdeveloped, and the mech…
View article: Maternal weight affects placental DNA methylation of genes involved in metabolic pathways in the common marmoset monkey (<i>Callithrix jacchus</i>)
Maternal weight affects placental DNA methylation of genes involved in metabolic pathways in the common marmoset monkey (<i>Callithrix jacchus</i>) Open
Accumulating evidence suggests that dysregulation of placental DNA methylation (DNAm) is a mechanism linking maternal weight during pregnancy to metabolic programming outcomes. The common marmoset, Callithrix jaccus , is a platyrrhine prim…
View article: Organizing and running bioinformatics hackathons within Africa: The H3ABioNet cloud computing experience
Organizing and running bioinformatics hackathons within Africa: The H3ABioNet cloud computing experience Open
The need for portable and reproducible genomics analysis pipelines is growing globally as well as in Africa, especially with the growth of collaborative projects like the Human Health and Heredity in Africa Consortium (H3Africa). The Pan-A…
View article: Methylomic profiles reveal sex-specific shifts in leukocyte composition associated with post-traumatic stress disorder
Methylomic profiles reveal sex-specific shifts in leukocyte composition associated with post-traumatic stress disorder Open
Post-traumatic stress disorder (PTSD) is a debilitating mental disorder precipitated by trauma exposure. However, only some persons exposed to trauma develop PTSD. There are sex differences in risk; twice as many women as men, develop a li…
View article: Organizing and running bioinformatics hackathons within Africa: The H3ABioNet cloud computing experience
Organizing and running bioinformatics hackathons within Africa: The H3ABioNet cloud computing experience Open
The need for portable and reproducible genomics analysis pipelines is growing globally as well as in Africa, especially with the growth of collaborative projects like the Human Health and Heredity in Africa Consortium (H3Africa). The Pan-A…
View article: Replication of Simulated Prebiotic Amphiphilic Vesicles in a Finite Environment Exhibits Complex Behavior That Includes High Progeny Variability and Competition
Replication of Simulated Prebiotic Amphiphilic Vesicles in a Finite Environment Exhibits Complex Behavior That Includes High Progeny Variability and Competition Open
We studied the simulated replication and growth of prebiotic vesicles composed of 140 phospholipids and cholesterol using our R-GARD (Real Graded Autocatalysis Replication Domain) formalism that utilizes currently extant lipids that have k…
View article: Extracellular Vesicles and the Promise of Continuous Liquid Biopsies
Extracellular Vesicles and the Promise of Continuous Liquid Biopsies Open
The rapid and accurate diagnosis of patients with minimally invasive procedures was once only found in science fiction. However, the discovery of extracellular vesicles (EVs) and their near ubiquity in body fluids, coupled with the advent …
View article: The core transcriptome of mammalian placentas and the divergence of expression with placental shape
The core transcriptome of mammalian placentas and the divergence of expression with placental shape Open
Introduction The placenta is arguably the most anatomically variable organ in mammals even though its primary function is conserved. Method Using RNA-Seq, we measured the expression profiles of 55 term placentas of 14 species of mammals re…
View article: Development of Bioinformatics Infrastructure for Genomics Research
Development of Bioinformatics Infrastructure for Genomics Research Open
For the past 4 years, the development of infrastructure support and human capacity through H3ABioNet, have significantly contributed to the establishment of African scientific networks, data analysis facilities, and training programs. Here…