Donald P. Gaver
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View article: Toward optimal mechanical ventilation of the injured lung: the role of expiratory duration
Toward optimal mechanical ventilation of the injured lung: the role of expiratory duration Open
Positive pressure mechanical ventilation is a life-saving intervention for patients with acute respiratory distress syndrome (ARDS), but it can also increase mortality by causing ventilator-induced lung injury (VILI) if applied inappropria…
View article: Mechanical ventilation energy analysis: Recruitment focuses injurious power in the ventilated lung
Mechanical ventilation energy analysis: Recruitment focuses injurious power in the ventilated lung Open
The progression of acute respiratory distress syndrome (ARDS) from its onset due to disease or trauma to either recovery or death is poorly understood. Currently, there are no generally accepted treatments aside from supportive care using …
View article: Meconium Influences Pulmonary Short-Chain Fatty Acid Concentration in Porcine Meconium Aspiration Model
Meconium Influences Pulmonary Short-Chain Fatty Acid Concentration in Porcine Meconium Aspiration Model Open
Introduction: The factors influencing meconium aspiration syndrome (MAS) severity remain poorly understood. In a piglet model of MAS, we hypothesized the respiratory microbiome would reflect the bacterial signature of meconium with short-c…
View article: Time-Controlled Adaptive Ventilation (TCAV): a personalized strategy for lung protection
Time-Controlled Adaptive Ventilation (TCAV): a personalized strategy for lung protection Open
Acute respiratory distress syndrome (ARDS) alters the dynamics of lung inflation during mechanical ventilation. Repetitive alveolar collapse and expansion (RACE) predisposes the lung to ventilator-induced lung injury (VILI). Two broad appr…
View article: Full-lung simulations of mechanically ventilated lungs incorporating recruitment/derecruitment dynamics
Full-lung simulations of mechanically ventilated lungs incorporating recruitment/derecruitment dynamics Open
This study developed and investigated a comprehensive multiscale computational model of a mechanically ventilated ARDS lung to elucidate the underlying mechanisms contributing to the development or prevention of VILI. This model is built u…
View article: Ratchet recruitment in the acute respiratory distress syndrome: lessons from the newborn cry
Ratchet recruitment in the acute respiratory distress syndrome: lessons from the newborn cry Open
Patients with acute respiratory distress syndrome (ARDS) have few treatment options other than supportive mechanical ventilation. The mortality associated with ARDS remains unacceptably high, and mechanical ventilation itself has the poten…
View article: Mechanical Power and Ventilator-induced Lung Injury: What Does Physics Have to Say?
Mechanical Power and Ventilator-induced Lung Injury: What Does Physics Have to Say? Open
"Mechanical Power and Ventilator-induced Lung Injury: What Does Physics Have to Say?." American Journal of Respiratory and Critical Care Medicine, 0(ja), pp.
View article: Protective ventilation in a pig model of acute lung injury: timing is as important as pressure
Protective ventilation in a pig model of acute lung injury: timing is as important as pressure Open
In a large animal model of ARDS, recruitment/derecruitment caused greater VILI than overdistension, whereas both mechanisms together caused severe lung damage. These findings suggest that eliminating cyclic recruitment and derecruitment du…
View article: Preparation and Structural Evaluation of Epithelial Cell Monolayers in a Physiologically Sized Microfluidic Culture Device
Preparation and Structural Evaluation of Epithelial Cell Monolayers in a Physiologically Sized Microfluidic Culture Device Open
In vitro microfluidic experimentation holds great potential to reveal many insights into the microphysiological phenomena occurring in conditions such as acute respiratory distress syndrome (ARDS) and ventilator-induced lung injury (VILI).…
View article: Electric Cell-Substrate Impedance Sensing (ECIS) as a Platform for Evaluating Barrier-Function Susceptibility and Damage from Pulmonary Atelectrauma
Electric Cell-Substrate Impedance Sensing (ECIS) as a Platform for Evaluating Barrier-Function Susceptibility and Damage from Pulmonary Atelectrauma Open
Biophysical insults that either reduce barrier function (COVID-19, smoke inhalation, aspiration, and inflammation) or increase mechanical stress (surfactant dysfunction) make the lung more susceptible to atelectrauma. We investigate the su…
View article: Computational lung modelling in respiratory medicine
Computational lung modelling in respiratory medicine Open
Computational modelling of the lungs is an active field of study that integrates computational advances with lung biophysics, biomechanics, physiology and medical imaging to promote individualized diagnosis, prognosis and therapy evaluatio…
View article: Atelectrauma Versus Volutrauma: A Tale of Two Time-Constants
Atelectrauma Versus Volutrauma: A Tale of Two Time-Constants Open
Objectives: Elucidate how the degree of ventilator-induced lung injury due to atelectrauma that is produced in the injured lung during mechanical ventilation is determined by both the timing and magnitude of the airway pressure profile. De…
View article: Surfactant-Mediated Airway and Acinar Interactions in a Multi-Scale Model of a Healthy Lung
Surfactant-Mediated Airway and Acinar Interactions in a Multi-Scale Model of a Healthy Lung Open
We present a computational multi-scale model of an adult human lung that combines dynamic surfactant physicochemical interactions and parenchymal tethering between ~16 generations of airways and subtended acini. This model simulates the he…
View article: The POOR Get POORer: A Hypothesis for the Pathogenesis of Ventilator-induced Lung Injury
The POOR Get POORer: A Hypothesis for the Pathogenesis of Ventilator-induced Lung Injury Open
Protective ventilation strategies for the injured lung currently revolve around the use of low Vt, ostensibly to avoid volutrauma, together with positive end-expiratory pressure to increase the fraction of open lung and reduce atelectrauma…
View article: Core Competencies for Undergraduates in Bioengineering and Biomedical Engineering: Findings, Consequences, and Recommendations
Core Competencies for Undergraduates in Bioengineering and Biomedical Engineering: Findings, Consequences, and Recommendations Open
This paper provides a synopsis of discussions related to biomedical engineering core curricula that occurred at the Fourth BME Education Summit held at Case Western Reserve University in Cleveland, Ohio in May 2019. This summit was organiz…
View article: Microscale to mesoscale analysis of parenchymal tethering: the effect of heterogeneous alveolar pressures on the pulmonary mechanics of compliant airways
Microscale to mesoscale analysis of parenchymal tethering: the effect of heterogeneous alveolar pressures on the pulmonary mechanics of compliant airways Open
In the healthy lung, bronchi are tethered open by the surrounding parenchyma; for a uniform distribution of these peribronchial structures, the solution is well known. An open question remains regarding the effect of a distributed set of c…
View article: Statistical Methods, Some Old, Some New: A Tutorial Survey
Statistical Methods, Some Old, Some New: A Tutorial Survey Open
This report describes some new graphical and robust methods of
\nstatistical analysis. It also contains brief accounts of
\nlogistic (categorical) regression, and of regression in the
\npresence of autocorrelated disturbances.
View article: Microscale distribution and dynamic surface tension of pulmonary surfactant normalize the recruitment of asymmetric bifurcating airways
Microscale distribution and dynamic surface tension of pulmonary surfactant normalize the recruitment of asymmetric bifurcating airways Open
We investigate the influence of bifurcation geometry, asymmetry of daughter airways, surfactant distribution, and physicochemical properties on the uniformity of airway recruitment of asymmetric bifurcating airways. To do so, we developed …
View article: Opportunity to Grow and Explore: Lessons from a Bioinnovation Graduate Student Summer Internship Program at the U.S. Food and Drug Administration
Opportunity to Grow and Explore: Lessons from a Bioinnovation Graduate Student Summer Internship Program at the U.S. Food and Drug Administration Open
The development of biomedical technologies and devices and their translation to the healthcare market requires a strong foundation in science and engineering, an understanding of clinical need, and well-honed entrepreneurial skills. Tulane…
View article: Estimation of the Pressure Drop Required for Lymph Flow through Initial Lymphatic Networks
Estimation of the Pressure Drop Required for Lymph Flow through Initial Lymphatic Networks Open
The results support the possibility for suction pressures generated from cyclic smooth muscle contractions of upstream collecting lymphatics being sufficient for fluid flow through an initial lymphatic network.