Deb Turner
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View article: A Bayesian nonparametric method for jointly clustering multiple spatial transcriptomic datasets and simultaneous gene selection
A Bayesian nonparametric method for jointly clustering multiple spatial transcriptomic datasets and simultaneous gene selection Open
In spatial transcriptomics, many algorithms are available for clustering cells into groups based on gene expression and location, although not without limitations. Such limitations include having to know the number of clusters, limiting in…
View article: A39 HEALTHY FIRST-DEGREE RELATIVES FROM MULTIPLEX FAMILIES VERSUS SIMPLEX HARBOR A HIGHER RISK OF DEVELOPING CROHN'S DISEASE AND ARE ASSOCIATED WITH SUBCLINICAL INFLAMMATION AND ALTERED MICROBIOME COMPOSITION
A39 HEALTHY FIRST-DEGREE RELATIVES FROM MULTIPLEX FAMILIES VERSUS SIMPLEX HARBOR A HIGHER RISK OF DEVELOPING CROHN'S DISEASE AND ARE ASSOCIATED WITH SUBCLINICAL INFLAMMATION AND ALTERED MICROBIOME COMPOSITION Open
Background Healthy individuals within families with multiple affected members (multiplex families) with Crohn’s disease (CD) have a notably high risk of developing CD. No large prospective pre-disease cohort has assessed differences in pre…
View article: P774 Maintenance treatment with vedolizumab in children with Inflammatory Bowel Disease: follow-up results from the prospective multicenter VEDOKIDS study
P774 Maintenance treatment with vedolizumab in children with Inflammatory Bowel Disease: follow-up results from the prospective multicenter VEDOKIDS study Open
Background We previously reported the effectiveness of vedolizumab (VDZ) to induce remission in children with CD and UC enrolled in the prospective,multicenter VEDOKIDS study.In this extended analysis,we aimed to explore the effectiveness …
View article: P292 Complications in elderly-onset Inflammatory Bowel Diseases – A population-based study from the epidemiological database of the Israeli IBD Research Nucleus (Epi-IIRN)
P292 Complications in elderly-onset Inflammatory Bowel Diseases – A population-based study from the epidemiological database of the Israeli IBD Research Nucleus (Epi-IIRN) Open
Background The population of elderly-onset (diagnosis >=65 years old) inflammatory bowel disease (IBD) is growing worldwide. Management of this population poses challenges, given the overall increased morbidity at the elderly age. Data …
View article: P671 Ustekinumab in paediatric patients with moderately to severely active Crohn's disease: Results from the UniStar study long-term extension
P671 Ustekinumab in paediatric patients with moderately to severely active Crohn's disease: Results from the UniStar study long-term extension Open
Background Ustekinumab (UST) is an approved biologic for the treatment of adults with Crohn’s disease (CD). Through 16 weeks (wks), UST demonstrated high rates of efficacy, low rates of immunogenicity, and safety in paediatric patients (pt…
View article: P899 Analysis of IL-23 receptor genetic variants associations with gut microbiome composition and barrier function in a cohort of healthy first-degree relatives of subjects with Crohn's disease
P899 Analysis of IL-23 receptor genetic variants associations with gut microbiome composition and barrier function in a cohort of healthy first-degree relatives of subjects with Crohn's disease Open
Background Single nucleotide polymorphisms (SNPs) in the Interleukin 23 receptor (IL23R) gene have been implicated in CD pathogenesis and shown in animal models to be involved in regulation of intestinal epithelial barrier function via the…
View article: P852 predictors of complicated disease course in UC in an administrative database: a nationwide study from the epi-IIRN
P852 predictors of complicated disease course in UC in an administrative database: a nationwide study from the epi-IIRN Open
Background There is uncertainty about the ability to predict disease course in UC, often since prediction studies are small and include selected population. We aimed to use a large nationwide cohort to explore predictors of disease course …
View article: P206 Demographic data and therapy before proctocolectomy with ileal pouch-anal anastomosis are associated with long-term pouch outcomes: A report from the epi-IIRN
P206 Demographic data and therapy before proctocolectomy with ileal pouch-anal anastomosis are associated with long-term pouch outcomes: A report from the epi-IIRN Open
Background Up to 25% of patients with ulcerative colitis (UC) may undergo restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA). Pouchitis may occur in 50–70% of patients, and ~30% may develop chronic pouchitis (CP) or Crohn…
View article: SETinSTONE: A retrospective impact assessment of human and environmental resource usage in Late Bronze Age Mycenaean Monumental Architecture, Greece.
SETinSTONE: A retrospective impact assessment of human and environmental resource usage in Late Bronze Age Mycenaean Monumental Architecture, Greece. Open
The influence of monumental construction on its human and material surroundings can be explored excellently in the context of Late Middle and Late Bronze Age (LBA) Mycenaean Greece. The overall aim of the ‘SETinSTONE’ project is precisely …
View article: P392. Low uptake of cervical screening in immunosuppressed patients with Inflammatory Bowel Disease at a district general hospital
P392. Low uptake of cervical screening in immunosuppressed patients with Inflammatory Bowel Disease at a district general hospital Open
Background: Thiopurines are widely used in inflammatory bowel disease(IBD) since they have shown efficacy in both ulcerative colitis(UC) and Crohn's disease(CD); whether or not thiopurines have different efficacy depending in the kind of I…