Donatella Cimini
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View article: Harnessing riboflavin production of food derived L. fermentum to develop a riboflavin bio-enriched oat beverage
Harnessing riboflavin production of food derived L. fermentum to develop a riboflavin bio-enriched oat beverage Open
Riboflavin is a key micronutrient and important precursor of the co-enzymes flavin mononucleotide (FMN) and flavin adenine-di-nucleotide (FAD) thereby playing a vital role in nutrient metabolism, growth and development of the human body. S…
View article: Biomechanical and biological features of hyaluronic acid in combination with chondroitin and platelet rich plasma for regenerative medicine applications
Biomechanical and biological features of hyaluronic acid in combination with chondroitin and platelet rich plasma for regenerative medicine applications Open
Currently, one of the most common treatments for osteoarthritis (OA) is viscosupplementation using intra-articular injectable gels, often based on glycosaminoglycans (GAGs), specifically hyaluronic acid (HA) and, in some cases, chondroitin…
View article: A Biotechnological Platform Based on the Newly Isolated <i>Streptococcus thermophilus D4</i> to Obtain Viable Biomass and Exopolysaccharides for Enterocytes Wound Healing
A Biotechnological Platform Based on the Newly Isolated <i>Streptococcus thermophilus D4</i> to Obtain Viable Biomass and Exopolysaccharides for Enterocytes Wound Healing Open
There is growing interest in newly isolated lactic acid bacteria from natural sources and traditional food manufacturing and transformation. Streptococcus thermophilus is able to improve the safety of dairy products, showing antioxidant an…
View article: Valorization of agro-waste for sustainable production and encapsulation of Kosakonia pseudosacchari TL13: towards advanced bioinoculants
Valorization of agro-waste for sustainable production and encapsulation of Kosakonia pseudosacchari TL13: towards advanced bioinoculants Open
View article: Sustainable and Integrated Biotechnological Approach for Cultivation and Encapsulation of Kosakonia Pseudosacchari Tl13
Sustainable and Integrated Biotechnological Approach for Cultivation and Encapsulation of Kosakonia Pseudosacchari Tl13 Open
View article: Bifidobacterium animalis subsp. lactis HN019 live probiotics and postbiotics: production strategies and bioactivity evaluation for potential therapeutic properties
Bifidobacterium animalis subsp. lactis HN019 live probiotics and postbiotics: production strategies and bioactivity evaluation for potential therapeutic properties Open
Introduction: B. animalis subsp. lactis HN019 is a commercially available well-characterized probiotic with documented effects on human health, such as the ability to enhance the immune function and to balance the intestinal microbiome. Th…
View article: Thermophilic biocatalysts for one-step conversion of citrus waste into lactic acid
Thermophilic biocatalysts for one-step conversion of citrus waste into lactic acid Open
Agri-food residues offer significant potential as a raw material for the production of L -lactic acid through microbial fermentation. Weizmannia coagulans , previously known as Bacillus coagulans , is a spore-forming, lactic acid-producing…
View article: Vegan grade medium component screening and concentration optimization for the fermentation of the probiotic strain <i>Lactobacillus paracasei</i> IMC 502® using Design of Experiments
Vegan grade medium component screening and concentration optimization for the fermentation of the probiotic strain <i>Lactobacillus paracasei</i> IMC 502® using Design of Experiments Open
Lactobacillus paracasei IMC502® is a commercially successful probiotic strain. However, there are no reports that investigate growth medium composition in relation to improved biomass production for this strain. The major outcome of the pr…
View article: Antioxidants positively regulate obesity dependent circRNAs - sperm quality - functional axis
Antioxidants positively regulate obesity dependent circRNAs - sperm quality - functional axis Open
Obesity is a pathophysiological condition, dependent on body fat accumulation, that progressively induces systemic oxidative stress/inflammation leading to a set of associated clinical manifestations, including male infertility. CircRNAs, …
View article: Evaluation of Different Activity of Lactobacillus spp. against Two Proteus mirabilis Isolated Clinical Strains in Different Anatomical Sites In Vitro: An Explorative Study to Improve the Therapeutic Approach
Evaluation of Different Activity of Lactobacillus spp. against Two Proteus mirabilis Isolated Clinical Strains in Different Anatomical Sites In Vitro: An Explorative Study to Improve the Therapeutic Approach Open
Urinary tract infections (UTIs) and catheter-associated UTIs (CAUTIs) are the principal hospital-acquired infections. Between these, bacterial prostatitis is believed to be the leading cause of recurrent UTIs in men under 50 years of age a…
View article: Vegan Grade Media Component Screening and concentration optimization for the fermentation of the probiotic strain Lactobacillus paracasei IMC 502 ® using Design of Experiment.
Vegan Grade Media Component Screening and concentration optimization for the fermentation of the probiotic strain Lactobacillus paracasei IMC 502 ® using Design of Experiment. Open
Lactobacillus paracasei IMC 502 is a commercially successful probiotic strain. Until now, there are no reports about the most suitable growth media composition for the highest possible biomass production of this strain. The major outcome o…
View article: Grape Stalk Valorization: An Efficient Re-Use of Lignocellulosic Biomass through Hydrolysis and Fermentation to Produce Lactic Acid from Lactobacillus rhamnosus IMC501
Grape Stalk Valorization: An Efficient Re-Use of Lignocellulosic Biomass through Hydrolysis and Fermentation to Produce Lactic Acid from Lactobacillus rhamnosus IMC501 Open
Lactobacillus rhamnosus is a homofermentative probiotic strain that was previously demonstrated to grow on lignocellulosic-derived raw materials and to convert glucose into L-lactic acid (LA) with yields that vary between 0.38 and 0.97 g/g…
View article: Novel Insights into circRNA Saga Coming from Spermatozoa and Epididymis of HFD Mice
Novel Insights into circRNA Saga Coming from Spermatozoa and Epididymis of HFD Mice Open
Obesity is a pathophysiological disorder associated with adiposity accumulation, oxidative stress, and chronic inflammation state that is progressively increasing in younger population worldwide, negatively affecting male reproductive skil…
View article: In Vitro Evaluation of the Most Active Probiotic Strains Able to Improve the Intestinal Barrier Functions and to Prevent Inflammatory Diseases of the Gastrointestinal System
In Vitro Evaluation of the Most Active Probiotic Strains Able to Improve the Intestinal Barrier Functions and to Prevent Inflammatory Diseases of the Gastrointestinal System Open
Background: The integrity of the intestinal barrier is fundamental to gut health and homeostasis; its damage can increase intestinal permeability, with translocation of bacteria and/or endotoxins from gut, and the onset of various intestin…
View article: Molecular Fingerprint of Human Pathological Synoviocytes in Response to Extractive Sulfated and Biofermentative Unsulfated Chondroitins
Molecular Fingerprint of Human Pathological Synoviocytes in Response to Extractive Sulfated and Biofermentative Unsulfated Chondroitins Open
Pharma-grade extractive chondroitin sulfate (CS) is widely used for osteoarthritis (OA) treatment. Recently, unsulfated biofermentative chondroitin (BC) proved positive effects in OA in vitro model. This study, based on primary pathologica…
View article: Evaluation of unsulfated biotechnological chondroitin in a knee osteoarthritis mouse model as a potential novel functional ingredient in nutraceuticals and pharmaceuticals
Evaluation of unsulfated biotechnological chondroitin in a knee osteoarthritis mouse model as a potential novel functional ingredient in nutraceuticals and pharmaceuticals Open
Osteoarthritis is a very disabling disease that can be treated with both non-pharmacological and pharmacological approaches. In the last years, pharmaceutical-grade chondroitin sulfate (CS) and glucosamine emerged as symptomatic slow-actin…
View article: Optimization of growth of Levilactobacillus brevis SP 48 and in vitro evaluation of the effect of viable cells and high molecular weight potential postbiotics on Helicobacter pylori
Optimization of growth of Levilactobacillus brevis SP 48 and in vitro evaluation of the effect of viable cells and high molecular weight potential postbiotics on Helicobacter pylori Open
Several Levilactobacillus brevis strains have the potential to be used as probiotics since they provide health benefits due to the interaction of live cells, and of their secreted products, with the host (tissues). Therefore, the developme…
View article: No Waste from Waste: Membrane-Based Fractionation of Second Cheese Whey for Potential Nutraceutical and Cosmeceutical Applications, and as Renewable Substrate for Fermentation Processes Development
No Waste from Waste: Membrane-Based Fractionation of Second Cheese Whey for Potential Nutraceutical and Cosmeceutical Applications, and as Renewable Substrate for Fermentation Processes Development Open
Second cheese whey (SCW) derived from buffalo milk is the main by-product of the mozzarella cheese dairy industry. The objective of this study was to develop a membrane-based purification procedure to obtain specific fractions from SCW and…
View article: Limosilactobacillus fermentum from buffalo milk is suitable for potential biotechnological process development and inhibits Helicobacter pylori in a gastric epithelial cell model
Limosilactobacillus fermentum from buffalo milk is suitable for potential biotechnological process development and inhibits Helicobacter pylori in a gastric epithelial cell model Open
View article: Potential of Biofermentative Unsulfated Chondroitin and Hyaluronic Acid in Dermal Repair
Potential of Biofermentative Unsulfated Chondroitin and Hyaluronic Acid in Dermal Repair Open
Chondroitin obtained through biotechnological processes (BC) shares similarities with both chondroitin sulfate (CS), due to the dimeric repetitive unit, and hyaluronic acid (HA), as it is unsulfated. In the framework of this experimental r…
View article: Production of Succinic Acid From Basfia succiniciproducens
Production of Succinic Acid From Basfia succiniciproducens Open
Basfia succiniciproducens is a facultative anaerobic capnophilic bacterium, isolated from rumen, that naturally produces high amounts of succinic acid by fixing CO 2 and using fumarate as final electron acceptor. This metabolic feature mak…
View article: Concentrated Buffalo Whey as Substrate for Probiotic Cultures and as Source of Bioactive Ingredients: A Local Circular Economy Approach towards Reuse of Wastewaters
Concentrated Buffalo Whey as Substrate for Probiotic Cultures and as Source of Bioactive Ingredients: A Local Circular Economy Approach towards Reuse of Wastewaters Open
Waste reduction and reuse is a crucial target of current research efforts. In this respect, the present study was focused on providing an example of local investment in a simple process configuration that converts whey into value-added com…
View article: Microbioreactor ( <scp>micro‐Matrix</scp> ) potential in aerobic and anaerobic conditions with different industrially relevant microbial strains
Microbioreactor ( <span>micro‐Matrix</span> ) potential in aerobic and anaerobic conditions with different industrially relevant microbial strains Open
Microscale fermentation systems are important high throughput tools in clone selection, and bioprocess set up and optimization, since they provide several parallel experiments in controlled conditions of pH, temperature, agitation, and gas…
View article: Unsulfated biotechnological chondroitin by itself as well as in combination with high molecular weight hyaluronan improves the inflammation profile in osteoarthritis in vitro model
Unsulfated biotechnological chondroitin by itself as well as in combination with high molecular weight hyaluronan improves the inflammation profile in osteoarthritis in vitro model Open
Several studies suggest that inflammation has a pivotal role during the progression of osteoarthritis (OA) and cytokines have been identified as the main process mediators. This study aimed to explore the ability to modulate the main OA pr…
View article: Timely Supplementation of Hydrogels Containing Sulfated or Unsulfated Chondroitin and Hyaluronic Acid Affects Mesenchymal Stromal Cells Commitment Toward Chondrogenic Differentiation
Timely Supplementation of Hydrogels Containing Sulfated or Unsulfated Chondroitin and Hyaluronic Acid Affects Mesenchymal Stromal Cells Commitment Toward Chondrogenic Differentiation Open
Mesenchymal stromal cells (MSCs) are currently used for cartilage cell therapy because of their well proven capacity to differentiate in chondrocytes. The advantage of MSC-based therapy is the possibility of producing a high number of chon…
View article: Chestnut Shells as Waste Material for Succinic Acid Production from Actinobacillus succinogenes 130Z
Chestnut Shells as Waste Material for Succinic Acid Production from Actinobacillus succinogenes 130Z Open
Currently, the full exploitation of waste materials for the production of value-added compounds is one of the potential solutions to lower costs and increase the sustainability of industrial processes. In this respect, the aim of this work…
View article: Production and purification of higher molecular weight chondroitin by metabolically engineered Escherichia coli K4 strains
Production and purification of higher molecular weight chondroitin by metabolically engineered Escherichia coli K4 strains Open
View article: Differential Secretome Profiling of Human Osteoarthritic Synoviocytes Treated with Biotechnological Unsulfated and Marine Sulfated Chondroitins
Differential Secretome Profiling of Human Osteoarthritic Synoviocytes Treated with Biotechnological Unsulfated and Marine Sulfated Chondroitins Open
Symptomatic slow-acting drugs (SYSADOA) are increasingly used as effective therapies for osteoarthritis, representing an attractive alternative to analgesics or non-steroidal anti-inflammatory drugs to relieve disease symptoms. Pharmaceuti…
View article: Improved production of succinic acid from Basfia succiniciproducens growing on A. donax and process evaluation through material flow analysis
Improved production of succinic acid from Basfia succiniciproducens growing on A. donax and process evaluation through material flow analysis Open
The use of fed-batch strategies for the growth of B. succiniciproducens on A. donax improved the titer and productivity of succinic acid on pre-pilot scale. Process evaluation through material flow analysis showed successful …
View article: Engineering S. equi subsp. zooepidemicus towards concurrent production of hyaluronic acid and chondroitin biopolymers of biomedical interest
Engineering S. equi subsp. zooepidemicus towards concurrent production of hyaluronic acid and chondroitin biopolymers of biomedical interest Open