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View article: Diagnostic Stratification of Pancreatic Ductal Adenocarcinoma via Metallomics and Blood-Based Biomarkers
Diagnostic Stratification of Pancreatic Ductal Adenocarcinoma via Metallomics and Blood-Based Biomarkers Open
Background: Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers, largely due to late diagnosis and the lack of reliable non-invasive biomarkers. Altered trace element homeostasis has been implicated in tumor biolog…
View article: The Persistent Threat of Chronic Inflammation on the Mortality Among Cervical Cancer Survivors: A Mendelian Randomization and Machine Learning Analysis Using UK Biobank and Chinese Cohort Data
The Persistent Threat of Chronic Inflammation on the Mortality Among Cervical Cancer Survivors: A Mendelian Randomization and Machine Learning Analysis Using UK Biobank and Chinese Cohort Data Open
No substantial causal associations were observed between CIMs and cervical cancer. The cohort study findings reveal the persistent impact of inflammation on cervical cancer prognosis, highlighting the crucial role of chronic inflammation w…
View article: Diagnostic Stratification of Prostate Cancer Through Blood-Based Biochemical and Inflammatory Markers
Diagnostic Stratification of Prostate Cancer Through Blood-Based Biochemical and Inflammatory Markers Open
Background: Prostate cancer (PCa) remains one of the most prevalent malignancies in men, with diagnostic challenges arising from the limited specificity of current biomarkers, like PSA. Improved stratification tools are essential to reduce…
View article: Fibromyalgia, Depression, and Autoimmune Disorders: An Interconnected Web of Inflammation
Fibromyalgia, Depression, and Autoimmune Disorders: An Interconnected Web of Inflammation Open
Background: Fibromyalgia, depression, and autoimmune diseases represent a triad of interconnected conditions characterized by overlapping biological pathways, including chronic inflammation, immune dysregulation, and neurochemical imbalanc…
View article: Heavy metals and prostate cancer: a new study with new findings
Heavy metals and prostate cancer: a new study with new findings Open
Heavy metals influence the development of several health conditions, including inflammation and cancer. This study investigates the relationship between heavy metal concentrations in plasma and urine, and the presence of benign prostatic h…
View article: Plasma Humanin and Non-Coding RNAs as Biomarkers of Endothelial Dysfunction in Rheumatoid Arthritis: A Pilot Study
Plasma Humanin and Non-Coding RNAs as Biomarkers of Endothelial Dysfunction in Rheumatoid Arthritis: A Pilot Study Open
Background: Rheumatoid arthritis (RA) is a chronic autoimmune disorder associated with an increased risk of cardiovascular disease (CVD), largely driven by peripheral endothelial dysfunction (ED). Humanin, a mitochondrial-derived peptide, …
View article: Investigating bilirubin concentrations in schizophrenia: A systematic review and meta-analysis
Investigating bilirubin concentrations in schizophrenia: A systematic review and meta-analysis Open
Schizophrenia, a severe mental disorder characterized by chronic disability and poor quality of life, has been shown to be associated with alterations in redox balance. Recent research has suggested a potential link between the antioxidant…
View article: Effects of the MCF-7 Exhausted Medium on hADSC Behaviour
Effects of the MCF-7 Exhausted Medium on hADSC Behaviour Open
Stem cells possess the ability to differentiate into different lineages and the ability to self-renew, thus representing an excellent tool for regenerative medicine. They can be isolated from different tissues, including the adipose tissue…
View article: Modulation of adipose-derived stem cell behavior by prostate pathology-associated plasma: insights from in vitro exposure
Modulation of adipose-derived stem cell behavior by prostate pathology-associated plasma: insights from in vitro exposure Open
Adipose-derived stem cells (ADSCs) are promising in regenerative medicine. Their proliferation, survival and activation are influenced by specific signals within their microenvironment, also known as niche. The stem cell niche is regulated…
View article: Platelet Dynamics in Neurodegenerative Disorders: Investigating the Role of Platelets in Neurological Pathology
Platelet Dynamics in Neurodegenerative Disorders: Investigating the Role of Platelets in Neurological Pathology Open
Background: Neurological disorders, particularly those associated with aging, pose significant challenges in early diagnosis and treatment. The identification of specific biomarkers, such as platelets (PLTs), has emerged as a promising str…
View article: Identification of Tissue miRNA Signatures for Pancreatic Ductal Adenocarcinoma
Identification of Tissue miRNA Signatures for Pancreatic Ductal Adenocarcinoma Open
Pancreatic ductal adenocarcinoma (PDAC), a neoplasm of the gastrointestinal tract, is the most common pancreatic malignancy (90%) and the fourth highest cause of cancer mortality worldwide. Surgery intervention is currently the only strate…
View article: Heavy metals in biological samples of cancer patients: a systematic literature review
Heavy metals in biological samples of cancer patients: a systematic literature review Open
The majority of the so-called heavy metals are suspected to be involved in a number of pathologies and play a role in human carcinogenesis. Some of them (i.e. arsenic (As), cadmium (Cd), chromium (Cr), lead (Pb), mercury (Hg) and nickel (N…
View article: Electrospun Nanofibers Encapsulated with Natural Products: A Novel Strategy to Counteract Skin Aging
Electrospun Nanofibers Encapsulated with Natural Products: A Novel Strategy to Counteract Skin Aging Open
The skin is the primary tissue affected by wounds and aging, significantly impacting its protective function. Natural products are widely used in cosmetics, representing a new approach to preventing age-related damage. Nanomedicine combine…
View article: Developing Strategies to Improve Diabetes Management in College-Going Young Adults
Developing Strategies to Improve Diabetes Management in College-Going Young Adults Open
it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed.The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge.Front…
View article: Assessing the Predictive Power of the Hemoglobin/Red Cell Distribution Width Ratio in Cancer: A Systematic Review and Future Directions
Assessing the Predictive Power of the Hemoglobin/Red Cell Distribution Width Ratio in Cancer: A Systematic Review and Future Directions Open
Background and Objectives: The hemoglobin (Hb)/red cell distribution width (RDW) ratio has emerged as an accessible, repeatable, and inexpensive prognostic factor that may predict survival in cancer patients. The focus of this systematic r…
View article: Harnessing Minimal Residual Disease as a Predictor for Colorectal Cancer: Promising Horizons Amidst Challenges
Harnessing Minimal Residual Disease as a Predictor for Colorectal Cancer: Promising Horizons Amidst Challenges Open
Minimal Residual Disease (MRD) detection has emerged as an independent factor in clinical and pathological cancer assessment offering a highly effective method for predicting recurrence in colorectal cancer (CRC). The ongoing research init…
View article: Age-Related Cognitive Decline, Focus on Microbiome: A Systematic Review and Meta-Analysis
Age-Related Cognitive Decline, Focus on Microbiome: A Systematic Review and Meta-Analysis Open
Aging is a complex process influenced by genetics and the environment, leading to physiological decline and increased susceptibility to diseases. Cognitive decline is a prominent feature of aging, with implications for different neurodegen…
View article: Decoding the Microbiome’s Influence on Rheumatoid Arthritis
Decoding the Microbiome’s Influence on Rheumatoid Arthritis Open
The aim is better to understand and critically explore and present the available data from observational studies on the pathogenetic role of the microbiome in the development of rheumatoid arthritis (RA). The electronic databases PubMed, S…
View article: Seasonality and Objective Physical Activity and Sedentary Behaviour among Older Adults from Four European Countries
Seasonality and Objective Physical Activity and Sedentary Behaviour among Older Adults from Four European Countries Open
Objective: The present study aimed to explore the relationship between objective physical activity and sedentary behaviour with seasonality among a sample of older adults living in four European countries. Methods: A sample of 169 older ad…
View article: Antioxidant, Anti-Inflammatory and Anti-Proliferative Properties of Stachys circinata on HepG2 and MCF7 Cells
Antioxidant, Anti-Inflammatory and Anti-Proliferative Properties of Stachys circinata on HepG2 and MCF7 Cells Open
According to the WHO, the overall age-standardized cancer rate keeps declining, and the number of cases diagnosed each year increases, remaining among the leading causes of death in 91 out of 172 recorded countries. In this context, novel …
View article: Humanin and Its Pathophysiological Roles in Aging: A Systematic Review
Humanin and Its Pathophysiological Roles in Aging: A Systematic Review Open
Background: Senescence is a cellular aging process in all multicellular organisms. It is characterized by a decline in cellular functions and proliferation, resulting in increased cellular damage and death. These conditions play an essenti…
View article: The prevalence of depression among parents of children/adolescents with type 1 diabetes: A systematic review and meta-analysis
The prevalence of depression among parents of children/adolescents with type 1 diabetes: A systematic review and meta-analysis Open
Background Emerging research indicates that depression among parents of children/adolescents with type 1 diabetes mellitus (T1DM) has increased significantly. However, the prevalence rates reported by different studies vary substantially. …
View article: Ferroptosis and Senescence: A Systematic Review
Ferroptosis and Senescence: A Systematic Review Open
Senescence is a cellular aging process in all multicellular organisms. It is characterized by a decay in cellular functions and proliferation, resulting in increased cellular damage and death. This condition plays an essential role in the …
View article: Ferroptosis and Senescence: A Systematic Review
Ferroptosis and Senescence: A Systematic Review Open
Background: Senescence is a cellular ageing process in all multicellular organisms. It is characterized by a decline in cellular functions and proliferation, resulting in increased cellular damage and death. This condition plays an essenti…
View article: Quantitative Metabolomics to Explore the Role of Plasma Polyamines in Colorectal Cancer
Quantitative Metabolomics to Explore the Role of Plasma Polyamines in Colorectal Cancer Open
Colorectal cancer (CRC) is one of the major public health and socio-economic problems, which management demands the development of non-invasive screening tests. Assessment of circulating polyamines could be a valuable tool, although analyt…
View article: Antineoplastic Properties by Proapoptotic Mechanisms Induction of Inula viscosa and Its Sesquiterpene Lactones Tomentosin and Inuviscolide
Antineoplastic Properties by Proapoptotic Mechanisms Induction of Inula viscosa and Its Sesquiterpene Lactones Tomentosin and Inuviscolide Open
Cancer is a complex disease including approximately 200 different entities that can potentially affect all body tissues. Among the conventional treatments, radiotherapy and chemotherapy are most often applied to different types of cancers.…