Howard J. Lim
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View article: Optimal bioaugmentation fosters a highly integrated and efficient microbial network for rapid trichloroethene dechlorination
Optimal bioaugmentation fosters a highly integrated and efficient microbial network for rapid trichloroethene dechlorination Open
View article: Zolbetuximab or Immunotherapy as the Initial Targeted Therapy in CLDN18.2-Positive, HER2-Negative Advanced Gastric Cancer: Weighing the Options
Zolbetuximab or Immunotherapy as the Initial Targeted Therapy in CLDN18.2-Positive, HER2-Negative Advanced Gastric Cancer: Weighing the Options Open
Advanced gastric/gastroesophageal junction (G/GEJ) adenocarcinoma remains a common and deadly form of cancer. Advances in G/GEJ cancer treatment have improved survival outcomes with the claudin-18.2 (CLDN18.2)-targeted agent, zolbetuximab,…
View article: THE USE OF VERBAL AND NONVERBAL COMMUNICATION STRATEGIES IN TEACHING ENGLISH TO EFL LEARNERS
THE USE OF VERBAL AND NONVERBAL COMMUNICATION STRATEGIES IN TEACHING ENGLISH TO EFL LEARNERS Open
Effective communication between teachers and students plays a crucial role in the success of English as a Foreign Language (EFL) learning. This study aims to describe the forms and functions of verbal and nonverbal communication used by En…
View article: An asynchronous electronic consent for improving consent in research among patients with cancer
An asynchronous electronic consent for improving consent in research among patients with cancer Open
Background Informed consent is essential to ensuring ethical conduct of clinical research in oncology, but can be challenging and time-consuming to implement. Electronic consenting (e-consent) may address these issues, but acceptability of…
View article: Efficacy and safety in tirzepatide‐treated Korean adults with type 2 diabetes—A post hoc analysis of <scp>SURPASS</scp> ‐ <scp>AP</scp> ‐combo and <scp>SURPASS</scp> ‐3
Efficacy and safety in tirzepatide‐treated Korean adults with type 2 diabetes—A post hoc analysis of <span>SURPASS</span> ‐ <span>AP</span> ‐combo and <span>SURPASS</span> ‐3 Open
Aims This post hoc analysis assessed the efficacy and safety data in tirzepatide‐treated Korean patients with type 2 diabetes ( T2D ). Materials and Methods Data specifically from Korean patients treated with tirzepatide 5, 10, or 15 mg in…
View article: Role of immune checkpoint inhibitor combinations in resectable and unresectable, embolization-eligible hepatocellular carcinoma
Role of immune checkpoint inhibitor combinations in resectable and unresectable, embolization-eligible hepatocellular carcinoma Open
Immune checkpoint inhibitor (ICI) combination regimens have recently become the new standard of care for advanced hepatocellular carcinoma (HCC). Large, phase III registrational trials of ICI-containing regimens in resectable and embolizat…
View article: Systemic adjuvant and perioperative chemotherapy following curative-intent liver metastasectomy in colorectal cancer—is it justified?
Systemic adjuvant and perioperative chemotherapy following curative-intent liver metastasectomy in colorectal cancer—is it justified? Open
Colorectal liver metastases (CRLM) pose a significant challenge in oncological care, with surgical resection offering the best chance for long-term survival. Despite curative-intent liver metastasectomy, recurrence rates remain high, under…
View article: Varying effectiveness of real-time biofeedback across various activities in preserving lumbar Lordotic curvature using an inertial measurement system
Varying effectiveness of real-time biofeedback across various activities in preserving lumbar Lordotic curvature using an inertial measurement system Open
Preserving lumbar lordotic curvature (LLC) is considered an important strategy for both managing low back pain (LBP) and preventing its exacerbation; however, this approach has traditionally been limited to postural education. This study a…
View article: Supplemental Table 1 from Clonal Hematopoiesis of Indeterminate Potential and its Association with Treatment Outcomes and Adverse Events in Patients with Solid Tumors
Supplemental Table 1 from Clonal Hematopoiesis of Indeterminate Potential and its Association with Treatment Outcomes and Adverse Events in Patients with Solid Tumors Open
TRIPOD checklist
View article: Supplemental Table 2 from Clonal Hematopoiesis of Indeterminate Potential and its Association with Treatment Outcomes and Adverse Events in Patients with Solid Tumors
Supplemental Table 2 from Clonal Hematopoiesis of Indeterminate Potential and its Association with Treatment Outcomes and Adverse Events in Patients with Solid Tumors Open
All CHIP variants identified in the study
View article: Supplemental Figure 2 from Clonal Hematopoiesis of Indeterminate Potential and its Association with Treatment Outcomes and Adverse Events in Patients with Solid Tumors
Supplemental Figure 2 from Clonal Hematopoiesis of Indeterminate Potential and its Association with Treatment Outcomes and Adverse Events in Patients with Solid Tumors Open
Progression free survival for patients on PREDiCT-l, split by tumor type. Therapy received is indicated in each title above each Kaplan Meier curve.
View article: Supplemental Figure 1 from Clonal Hematopoiesis of Indeterminate Potential and its Association with Treatment Outcomes and Adverse Events in Patients with Solid Tumors
Supplemental Figure 1 from Clonal Hematopoiesis of Indeterminate Potential and its Association with Treatment Outcomes and Adverse Events in Patients with Solid Tumors Open
VAF of all CHIP variants split by cohort
View article: Toxicological assessment of cigarette filter-derived microplastics in Daphnia magna
Toxicological assessment of cigarette filter-derived microplastics in Daphnia magna Open
Cigarette filters are the most common form of litter worldwide and pose significant ecological risks because they degrade into microfibers and microplastics in aquatic environments. While previous studies have focused on the acute toxicity…
View article: Comparison of actual and automated CT measurements of urinary stone size: a phantom study
Comparison of actual and automated CT measurements of urinary stone size: a phantom study Open
Urinary stone size is key in determining treatment. Although computed tomography (CT) scans are widely used for diagnosing urinary stones, measurements of stone size obtained from CT images may be inaccurate compared to actual size. Twenty…
View article: Canadian Association of Radiologists Cancer Diagnostic Imaging Referral Guideline
Canadian Association of Radiologists Cancer Diagnostic Imaging Referral Guideline Open
The Canadian Association of Radiologists (CAR) Cancer Expert Panel is made up of physicians from the disciplines of radiology, medical oncology, surgical oncology, radiation oncology, family medicine/general practitioner oncology, a patien…
View article: Supplemental Table 2 from Clonal Hematopoiesis of Indeterminate Potential and its Association with Treatment Outcomes and Adverse Events in Patients with Solid Tumors
Supplemental Table 2 from Clonal Hematopoiesis of Indeterminate Potential and its Association with Treatment Outcomes and Adverse Events in Patients with Solid Tumors Open
All CHIP variants identified in the study
View article: Figure 3 from Clonal Hematopoiesis of Indeterminate Potential and its Association with Treatment Outcomes and Adverse Events in Patients with Solid Tumors
Figure 3 from Clonal Hematopoiesis of Indeterminate Potential and its Association with Treatment Outcomes and Adverse Events in Patients with Solid Tumors Open
CHIP and treatment outcomes. Kaplan–Meier curves showing the difference in outcome between patients with (CHIP+) and without CHIP (CHIP−) and outcomes on different therapies. PFS is shown on the left two columns for all three cohorts, and …
View article: Figure 1 from Clonal Hematopoiesis of Indeterminate Potential and its Association with Treatment Outcomes and Adverse Events in Patients with Solid Tumors
Figure 1 from Clonal Hematopoiesis of Indeterminate Potential and its Association with Treatment Outcomes and Adverse Events in Patients with Solid Tumors Open
Consort diagram and reasons for exclusion.
View article: Data from Clonal Hematopoiesis of Indeterminate Potential and its Association with Treatment Outcomes and Adverse Events in Patients with Solid Tumors
Data from Clonal Hematopoiesis of Indeterminate Potential and its Association with Treatment Outcomes and Adverse Events in Patients with Solid Tumors Open
Clonal hematopoiesis of indeterminate potential (CHIP) is the clonal expansion of hematopoietic stem cells from somatic mutations. It is a common incidental finding in cell-free DNA (cfDNA). We investigated the incidence of CHIP in cfDNA f…
View article: Table 1 from Clonal Hematopoiesis of Indeterminate Potential and its Association with Treatment Outcomes and Adverse Events in Patients with Solid Tumors
Table 1 from Clonal Hematopoiesis of Indeterminate Potential and its Association with Treatment Outcomes and Adverse Events in Patients with Solid Tumors Open
Baseline characteristics of the included patients
View article: Figure 2 from Clonal Hematopoiesis of Indeterminate Potential and its Association with Treatment Outcomes and Adverse Events in Patients with Solid Tumors
Figure 2 from Clonal Hematopoiesis of Indeterminate Potential and its Association with Treatment Outcomes and Adverse Events in Patients with Solid Tumors Open
Prevalence of CHIP variants across cohorts and CHIP association with age. A, Percentage of patients with CHIP variants in each cohort. Insert shows the breakdown by tumor type in the PREDiCT-l cohort. B, Number of patients wi…
View article: Supplemental Figure 2 from Clonal Hematopoiesis of Indeterminate Potential and its Association with Treatment Outcomes and Adverse Events in Patients with Solid Tumors
Supplemental Figure 2 from Clonal Hematopoiesis of Indeterminate Potential and its Association with Treatment Outcomes and Adverse Events in Patients with Solid Tumors Open
Progression free survival for patients on PREDiCT-l, split by tumor type. Therapy received is indicated in each title above each Kaplan Meier curve.
View article: Figure 4 from Clonal Hematopoiesis of Indeterminate Potential and its Association with Treatment Outcomes and Adverse Events in Patients with Solid Tumors
Figure 4 from Clonal Hematopoiesis of Indeterminate Potential and its Association with Treatment Outcomes and Adverse Events in Patients with Solid Tumors Open
CHIP and adverse events. A, Percentage of patients on each treatment that had an adverse event on therapy, split by cohort and treatment. B, Proportions of patients with adverse events split by CHIP status. Lighter shades ind…
View article: Supplemental Figure 1 from Clonal Hematopoiesis of Indeterminate Potential and its Association with Treatment Outcomes and Adverse Events in Patients with Solid Tumors
Supplemental Figure 1 from Clonal Hematopoiesis of Indeterminate Potential and its Association with Treatment Outcomes and Adverse Events in Patients with Solid Tumors Open
VAF of all CHIP variants split by cohort
View article: Supplemental Table 1 from Clonal Hematopoiesis of Indeterminate Potential and its Association with Treatment Outcomes and Adverse Events in Patients with Solid Tumors
Supplemental Table 1 from Clonal Hematopoiesis of Indeterminate Potential and its Association with Treatment Outcomes and Adverse Events in Patients with Solid Tumors Open
TRIPOD checklist
View article: Toxicological Assessment of Cigarette Filter-Derived Microplastics in Daphnia Magna
Toxicological Assessment of Cigarette Filter-Derived Microplastics in Daphnia Magna Open
View article: Clonal Hematopoiesis of Indeterminate Potential and its Association with Treatment Outcomes and Adverse Events in Patients with Solid Tumors
Clonal Hematopoiesis of Indeterminate Potential and its Association with Treatment Outcomes and Adverse Events in Patients with Solid Tumors Open
Clonal hematopoiesis of indeterminate potential (CHIP) is the clonal expansion of hematopoietic stem cells from somatic mutations. It is a common incidental finding in cell-free DNA (cfDNA). We investigated the incidence of CHIP in cfDNA f…
View article: Canadian Consensus Recommendations for Predictive Biomarker Testing in Gastric and Gastroesophageal Junction Adenocarcinoma
Canadian Consensus Recommendations for Predictive Biomarker Testing in Gastric and Gastroesophageal Junction Adenocarcinoma Open
Gastric cancer is common globally and has a generally poor prognosis with a low 5-year survival rate. Targeted therapies and immunotherapies have improved the treatment landscape, providing more options for efficacious treatment. The use o…
View article: International experts consensus on optimal central vascular access device selection and management for patients with cancer
International experts consensus on optimal central vascular access device selection and management for patients with cancer Open
Background: In patients with cancer, the choice of an appropriate venous access device is crucial for effective treatment, minimizing complications, and reducing healthcare costs. Key management decisions, such as the timing of device remo…
View article: Mapping in silico genetic networks of the KMT2D tumour suppressor gene to uncover novel functional associations and cancer cell vulnerabilities
Mapping in silico genetic networks of the KMT2D tumour suppressor gene to uncover novel functional associations and cancer cell vulnerabilities Open